A devices' game of thrones: cardiac resynchronization therapy vs. pacemaker.

AIMS: Oversensing can interfere with biventricular pacing. Cardiac Resynchronization Therapy (CRT) output inhibition due to automatic brady mode change from a sensing to a pacing mode of a previously implanted pacemaker as it reached battery capacity depleted indicator has not been previously published in the medical literature. METHODS AND RESULTS: We report the first case of CRT output inhibition in a pacemaker dependent patient due to electrical stimuli from a previously right-sided implanted pacemaker, after unaware reversion of OVO mode (O = no chambers paced; V = ventricular sensing; O = no response to sensing) to backup VVI (V = ventricular pacing; V = ventricular sensing; I = inhibitory response to sensing) when it reached the elective replacement interval. CONCLUSION: This paper emphasizes the importance of knowing the distinct pacemaker brady mode behaviours after battery capacity depleted indicator has been reached, according to the pacemakers' manufacturer, including the possibility of automatic brady mode change from sensing to pacing mode. It also highlights the potential for severe bradycardia or asystole of this automatic brady mode change from a previously implanted pacemaker in pacemaker dependent patients submitted to CRT upgrade.

Effect of Cinnamon Tea on Postprandial Glucose Concentration.

Glycaemic control, in particular at postprandial period, has a key role in prevention of different diseases, including diabetes and cardiovascular events. Previous studies suggest that postprandial high blood glucose levels (BGL) can lead to an oxidative stress status, which is associated with metabolic alterations. Cinnamon powder has demonstrated a beneficial effect on postprandial glucose homeostasis in animals and human models. The purpose of this study is to investigate the effect of cinnamon tea (C. burmannii) on postprandial capillary blood glucose level on nondiabetic adults. Participants were given oral glucose tolerance test either with or without cinnamon tea in a randomized clinical trial. The data revealed that cinnamon tea administration slightly decreased postprandial BGL. Cinnamon tea ingestion also results in a significantly lower postprandial maximum glucose concentration and variation of maximum glucose concentration (p < 0.05). Chemical analysis showed that cinnamon tea has a high antioxidant capacity, which may be due to its polyphenol content. The present study provides evidence that cinnamon tea, obtained from C. burmannii, could be beneficial for controlling glucose metabolism in nondiabetic adults during postprandial period.

Mercury levels assessment in hair of riverside inhabitants of the Tapajós River, Pará State, Amazon, Brazil: fish consumption as a possible route of exposure.

The study present evaluated the levels of mercury (Hg) and methylmercury (MeHg) in hair samples of people from Barreiras community, riverside inhabitants of the Tapajós River (Pará, Brazil), an area impacted by clandestine gold mining, as well as we analyzed the levels of Hg and Se (selenium) in nine fish species (carnivores and non-carnivorous) from the Tapajós River, which stand out as the main species consumed by riverside inhabitants, to evaluate a relationship between frequency of fish consumption and Hg concentration, and also to evaluate possible mechanisms of fish protection (or non-protection) to Hg exposure by Se. Furthermore we analyze the water quality to evaluate the environmental trophic state, fact responsible by creating conditions that can potentiate the effects of toxic mercury. Concentrations of Hg and MeHg were analyzed in hair samples of 141 volunteers in different age band. Of those, 84.40% of samples present values above the threshold for biological tolerance, which is 6.00µgg(-1) of total Hg in hair. Total Hg, in men there was a variation of 2.07-24.93µgg(-1), while for women the variation was 4.84-27.02µgg(-1). Consequently, the level of MeHg in men presented a variation of 1.49-19.57µgg(-1), with an average of 11.68µgg(-1), while with women the variation was from 3.73 to 22.35µgg(-1), with an average of 10.38µgg(-1). In fish species, Hg concentrations in carnivorous species had an average of 0.66µgg(-1), higher than that permitted by current legislation, ranging from 0.30 to 0.98µgg(-1), while the non-carnivorous species have values below the recommended by the legislation averaging 0.09µgg(-1), ranging between 0.02 and 0.44µgg(-1). For Se in fish, show that among carnivores, the contents of Se ranged between 0.18 and 0.54µgg(-1) with a mean of 0.34µgg(-1), while for non-carnivores these values were of the order of 0.16-0.56µgg(-1), with an average of 0.32µgg(-1). In surface water quality variables at the sampling points all showed values in accordance with the range established by current legislation. In this regard, the results provided by this study, while not conclusive, are strong indicators that despite not having been shown the relationship between the concentration of mercury in hair and feeding habits along the Tapajós River basin communities showed that a plausible correlation exists between levels of mercury and selenium in fish. This fact may serve as a subsidy to research human health, because in the Amazon, there is still a lot to examine with regards to the full understanding of the Se cycle.

[Mercury exposure evaluation among Pakaanóva Indians, Amazon Region, Brazil]. / Avaliação dos níveis de exposição ao mercúrio entre índios Pakaanóva, Amazônia, Brasil.

A cross-sectional study was conducted to evaluate mercury (Hg) exposure among 910 Pakaan va Indians from the counties of Guajar Mirim and Nova Marmor , Rond nia State, Brazil. Individual hair samples were taken from the occipital region, and Hg was measured by atomic absorption spectrometry with cold vapor generation. Mean Hg in hair samples was 8.37 micro g/g (range 0.52-83.89), indicating high exposure. Young children (< 2 years old) showed a mean Hg of 10.54 micro g/g, and children from 3 to 5 years old had a mean Hg of 9.34 micro g/g. Mercury levels in women (8,91 micro g/g) were higher than in men (7.55 micro g/g), and this difference was significant (t = 3.26; p < 0.01). These results indicate the need for surveillance programs and complementary studies including the Pakaan va Indians in Rond nia State.