ABSTRACT
High temperature generated by photothermal therapy (PTT) can trigger an inflammatory response at the tumor site, which not only limits the efficacy of PTT but also increases the risk of tumor metastasis and recurrence. In light of the current limitations posed by inflammation in PTT, several studies have revealed that inhibiting PTT-induced inflammation can significantly improve the efficacy of cancer treatment. In this review, we summarize the research progress made in combining anti-inflammatory strategies to enhance the effectiveness of PTT. The goal is to offer valuable insights for developing better-designed photothermal agents in clinical cancer therapy.
Subject(s)
Hyperthermia, Induced , Neoplasms , Humans , Photothermal Therapy , Phototherapy , Neoplasms/drug therapy , Neoplasms/pathology , Inflammation/drug therapy , Anti-Inflammatory AgentsABSTRACT
A homotypic cancer cell membrane camouflaged MOF-based nanoreactor with the photothermal-starvation effect has been developed for synergistic suppression of intracellular defensive systems for enhanced cancer treatment.
Subject(s)
Antineoplastic Agents/pharmacology , Biomimetic Materials/pharmacology , Metal-Organic Frameworks/pharmacology , Nanostructures/chemistry , Neoplasms/drug therapy , Phototherapy , Animals , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Apoptosis/drug effects , Biomimetic Materials/chemical synthesis , Biomimetic Materials/chemistry , Cell Line, Tumor , Cell Membrane/drug effects , Cell Proliferation/drug effects , Cell Survival/drug effects , Drug Screening Assays, Antitumor , Metal-Organic Frameworks/chemical synthesis , Metal-Organic Frameworks/chemistry , Mice , Neoplasms/pathology , Particle Size , Surface PropertiesABSTRACT
A novel Au-Se nanoprobe with remarkable anti-interference ability for glutathione was developed for real-time in situ monitoring of the upstream and downstream regulatory relationship between uPA and MMP-9 proteins in the pathway.
Subject(s)
Gold/chemistry , Matrix Metalloproteinase 9/analysis , Nanostructures/chemistry , Neoplasms/diagnostic imaging , Optical Imaging/methods , Selenium/chemistry , Urokinase-Type Plasminogen Activator/analysis , Glutathione/chemistry , Humans , MCF-7 Cells , Nanostructures/ultrastructure , Neoplasms/enzymologyABSTRACT
The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual-targeted photothermal agent.