ABSTRACT
Objective To explore the short-term efficacy of Xiaoaiping injection assisted TP regimen (taxotere + paraplatin)in the treatment of advanced non-small cell lung cancer(NSCLC)and its effects on immune function,adverse reactions and quality of life. Methods One-hundred cases of patients with advanced NSCLC who were admitted to the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2014 to October 2017 were selected as subjects,and they were randomly divided into Xiaoaiping group (n = 55)and TP group(n = 45)according to the random number table method. Patients in TP group were given TP regimen chemotherapy,and patients in Xiaoaiping group were added with Xiaoaiping injection on the basis of TP group. The short-term efficacy and changes of immune function,adverse reactions and quality of life were observed in the two groups,and statistical comparison was performed. Results After treatment,the response rates of patients in Xiaoaiping group and TP group were 49. 09％(27 / 55)and 28. 89％(13 / 45) respectively,with a significant difference(χ2 = 4. 209,P = 0. 040). After treatment,the disease control rates of patients in Xiaoaiping group and TP group were 83. 64％(46 / 55)and 73. 33％(33 / 45)respectively,with no significant difference(χ2 = 1. 584,P = 0. 208). The CD4 +(40. 98％ ± 5. 73％ vs. 33. 47％ ± 5. 06％ ), CD4 + / CD8 +(1. 53 ±0. 34 vs. 1. 25 ±0. 26)and nature killer(NK)cells(19. 59％ ± 4. 77％ vs. 17. 05％ ± 4. 12％ )in Xiaoaiping group after treatment were significantly higher than those in TP group(t = 6. 869,P <0. 001;t = 4. 542,P < 0. 001;t = 5. 609,P < 0. 001). And there was no significant difference in CD8 +between the two groups(26. 83％ ± 5. 21％ vs. 26. 58％ ± 5. 20％ ;t = 0. 239,P = 0. 812). The incidence rates of leucopenia(50. 91％ vs. 75. 56％ ),thrombocytopenia(38. 18％ vs. 66. 67％ )and hemoglobin re-duction(52. 73％ vs. 77. 78％ )in Xiaoaiping group were lower than those in TP group,with significant diffe-rences(χ2 = 6. 381,P = 0. 012;χ2 = 8. 306,P = 0. 005;χ2 = 6. 741,P = 0. 009). There were no significant differences in the incidence rates of nausea and vomiting(32. 73％ vs. 48. 89％ ),diarrhea constipation (45. 45％ vs. 60. 00％ )and liver damage(7. 27％ vs. 13. 33％ )between the two groups(χ2 = 2. 694,P =0. 101;χ2 = 2. 098,P = 0. 148;χ2 = 0. 449,P = 0. 503). After treatment,the Karnofsky functional status scores of patients in Xiaoaiping group and TP group were 81. 47 ± 11. 26 and 73. 38 ± 10. 45 respectively,and the stability rates of quality of life improvement were 78. 18％(43 / 55)and 57. 78％(26 / 45)respectively, with significant differences(t = 3. 691,P < 0. 001;χ2 = 4. 817,P = 0. 028). Conclusion Xiaoaiping injec-tion assisted TP regimen has a good short-term efficacy on advanced NSCLC,which can effectively improve immune function,reduce adverse reactions and improve the quality of life.
ABSTRACT
OBJECTIVE: To explore the effects of Jiawei Xiaoyao Pills (JWXYP) on immune system of mice exposed to chronic emotional stress, and to compare its effects with blockage of hypothalamic-pituitary-adrenal cortex axis (HPAA) by metyrapone. METHODS: Eighty male mice were randomly divided into eight groups: normal saline-treated group, normal saline-treated stress group, JWXYP-treated group, JWXYP-treated stress group, metyrapone-treated group, metyrapone-treated stress group, metyrapone and JWXYP-treated group and metyrapone and JWXYP-treated stress group. A box of electrical shock was used to induce chronic emotional stress in mice. The metyrapone was applied to blocking the HPAA. The JWXYP, a classical formula of traditional Chinese medicine, which can alleviate the damages caused by chronic emotional stress, was also used to compare its effects with that of metyrapone. The body weight, thymus index, rate of apoptosis in thymus, serum concentration of glucocorticoid, activity of natural killer cells, lymphocyte transmission rate of mice were all measured and examined after interventions. The pathological changes of thymus tissue were observed. RESULTS: The thymus index, activity of natural killer cells and lymphocyte transmission rate were lower while the rate of apoptosis in thymus as well as the severity degree of pathological damages in thymus tissue were increased in the different drug-treated stress groups as compared with those in the corresponding drug-treated groups without stress. The activity of natural killer cells and the lymphocyte transmission rate induced by lipopolysaccharide were increased while the serum concentration of glucocorticoid and the severity degree of pathological damages in thymus tissue were decreased in both the metyrapone-treated stress group and JWXYP-treated stress group as compared with those in the normal saline-treated stress group. The combined intervention of metyrapone and JWXYP did not show better effects on immune system in mice exposed to chronic emotional stress than single metyrapone or JWXYP intervention. CONCLUSION: Blockage of HPAA by metyrapone intervention shows a significant protective effect on immune system in mice exposed to chronic emotional stress, and the JWXYP also exerts a similar protective effect against damages induced by chronic emotional stress. The HPAA may be one of the action targets of protective effects of JWXYP.