Search | VHL TCIM Americas

[A case of acute myocardial injury caused by carbon dioxide poisoning treated by hyperbaric oxygen].

Sun, H Z; Gao, J L; Li, S Y.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi ; 39(5): 373-374, 2021 05 20.

Article in Chinese | MEDLINE | ID: mdl-34074086

Subject(s)

Carbon Monoxide Poisoning , Hyperbaric Oxygenation , Carbon Dioxide , Carbon Monoxide Poisoning/therapy , Gases , Humans , Oxygen

Helicases as antiviral drug targets.

Huang, J D; Zheng, B J; Sun, H Z.

Hong Kong Med J ; 14 Suppl 4: 36-8, 2008 Aug.

Article in English | MEDLINE | ID: mdl-18708673

ABSTRACT

1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.

Subject(s)

DNA Helicases/pharmacology , Severe Acute Respiratory Syndrome/drug therapy , Severe acute respiratory syndrome-related coronavirus/drug effects , Virus Replication/drug effects , Animals , Antiviral Agents/pharmacology , Cells, Cultured , Chlorocebus aethiops , DNA Helicases/genetics , Drug Delivery Systems , Drug Evaluation, Preclinical , Severe acute respiratory syndrome-related coronavirus/genetics , Sensitivity and Specificity , Severe Acute Respiratory Syndrome/genetics , Severe Acute Respiratory Syndrome/virology , Vero Cells/cytology , Vero Cells/drug effects , Virus Replication/genetics

[A sesquiterpene lactone of grand-cycle carbon skeleton structure. VI. Determination of chemical structure of neo-aristolactone].

Lou, F C; Wu, M Y; Sun, H Z; Chen, Y Z; Xu, B J.

Yao Xue Xue Bao ; 27(1): 37-41, 1992.

Article in Chinese | MEDLINE | ID: mdl-1529711

Subject(s)

Drugs, Chinese Herbal/chemistry , Sesquiterpenes/isolation & purification , Molecular Conformation , Sesquiterpenes/chemistry

[Screening of active anti-inflammatory-immunosuppressive and antifertile compositions from Tripterygium wilfordii. I. Screening of 8 components from total glucosides of Tripterygium wilfordii (TII)].

Zheng, J R; Fang, J L; Gu, K X; Xu, L F; Gao, J W; Guo, H Z; Yu, Y H; Sun, H Z.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 9(5): 317-22, 1987 Oct.

Article in Chinese | MEDLINE | ID: mdl-2968853

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/isolation & purification , Glucosides/analysis , Glycosides/analysis , Immunosuppressive Agents/isolation & purification , Plants, Medicinal/analysis , Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Female , Fertility/drug effects , Glucosides/pharmacology , Male , Mice , Rats , Rats, Inbred Strains

[Screening of active anti-inflammatory-immunosuppressive and antifertile components from Tripterygium wilfordii. II. Screening of 5 monomers from total glucosides of Tripterygium wilfordii (TII)].

Zheng, J R; Fang, J L; Gu, K X; Yin, Y Q; Xu, L F; Gao, J W; Guo, H Z; Yu, Y H; Sun, H Z.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 9(5): 323-8, 1987 Oct.

Article in Chinese | MEDLINE | ID: mdl-2968854

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/isolation & purification , Epididymis/drug effects , Glucosides/analysis , Glycosides/analysis , Immunosuppressive Agents/isolation & purification , Plants, Medicinal/analysis , Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Epididymis/pathology , Glucosides/pharmacology , Male , Mice , Mice, Inbred C57BL , Rats , Rats, Inbred Strains , Spermatogenesis/drug effects , Testis/drug effects , Testis/pathology

[Effects of total glycosides of Tripterygium wilfordii on the reproductive organs of experimental animals. III. Dynamic observations on the reproductive organs and fertility in mice].

Zheng, J R; Fang, J L; Gao, J W; Guo, H Z; Xu, L F; Yeng, Y P; Yu, Y H; Sun, H Z.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 8(1): 19-23, 1986 Feb.

Article in Chinese | MEDLINE | ID: mdl-2943438

Subject(s)

Fertility/drug effects , Glycosides/pharmacology , Plants, Medicinal/analysis , Animals , Estrus/drug effects , Female , Male , Mice , Ovary/drug effects , Rats , Sperm Motility/drug effects , Testis/drug effects , Uterus/drug effects

[Effects of total glycosides of Tripterygium wiifordii on the reproductive organs of experimental animals. II. Experiments in female rats].

Zheng, J R; Fang, J L; Xu, L F; Gao, J W; Guo, H Z; Li, Z R; Sun, H Z.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 7(4): 256-9, 1985 Aug.

Article in Chinese | MEDLINE | ID: mdl-2939986

Subject(s)

Glycosides/pharmacology , Medicine, Chinese Traditional , Medicine, East Asian Traditional , Plants, Medicinal , Uterus/drug effects , Animals , Estradiol/blood , Estrus/drug effects , Female , Organ Size/drug effects , Ovary/drug effects , Ovary/ultrastructure , Progesterone/blood , Rats , Rats, Inbred Strains

[Effects of total glycosides of Tripterygium wilfordii on animal reproductive organs I. Experiments of male rats].

Zheng, J R; Fang, J L; Xu, L F; Gao, J W; Guo, H Z; Li, Z R; Sun, H Z.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 7(1): 1-5, 1985 Feb.

Article in Chinese | MEDLINE | ID: mdl-3158412

Subject(s)

Glycosides/pharmacology , Medicine, Chinese Traditional , Medicine, East Asian Traditional , Plants, Medicinal , Testis/drug effects , Animals , Male , Rats , Spermatozoa/drug effects , Testosterone/blood

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