ABSTRACT
En este artículo se profundiza sobre los beneficios que la musicoterapia puede aportar al nivel cognitivo y/o conductual de los ancianos con demencia. Para ello se realizó una búsqueda bibliográfica de artículos de ensayos controlados aleatorios, ensayos casos-control y estudios pilotos, publicados desde enero de 2000 a enero de 2012 en las bases de datos Cochrane, MEDLINE, Dialnet y CSIC, centrados en la comparación de la musicoterapia como tratamiento no farmacológico en las personas mayores de 65 años con demencia moderada, frente a su tratamiento terapéutico-ocupacional habitual. Se seleccionaron 10 artículos en función de los criterios de inclusión. El análisis de los resultados sugiere que la musicoterapia mejora en las personas con demencia su nivel conductual, cognitivo y de comportamiento social (AU)
An in-depth review is presented the possible benefits of music therapy in relation to the cognitive and/or behavioural level of elderly patients with dementia. We have carried out a systematic review of randomized controlled trials, case-control and pilot studies published from January 2000 to January 2012 using the Cochrane Database of Systematic Reviews, MEDLINE, Dialnet and CSIC. We focused on comparison of music therapy as non-pharmacological therapy, in patients over 65 years of age with moderate dementia, with regular therapeutic and occupational treatment. Ten articles were selected based on the inclusion criteria. The analysis of the results suggest that music Therapy influences the elderly people with dementia in a positive way by improving levels of behavioural and cognitive functioning and social participation (AU)
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Music Therapy/instrumentation , Music Therapy/methods , Dementia/psychology , Dementia/rehabilitation , Depression/psychology , Aged/psychology , Music Therapy/organization & administration , Music Therapy/standards , Cognitive Behavioral Therapy/methods , Music/psychology , Health Services for the Aged/standards , Health Services for the AgedABSTRACT
An in-depth review is presented the possible benefits of music therapy in relation to the cognitive and/or behavioural level of elderly patients with dementia. We have carried out a systematic review of randomized controlled trials, case-control and pilot studies published from January 2000 to January 2012 using the Cochrane Database of Systematic Reviews, MEDLINE, Dialnet and CSIC. We focused on comparison of music therapy as non-pharmacological therapy, in patients over 65 years of age with moderate dementia, with regular therapeutic and occupational treatment. Ten articles were selected based on the inclusion criteria. The analysis of the results suggest that music Therapy influences the elderly people with dementia in a positive way by improving levels of behavioural and cognitive functioning and social participation.
Subject(s)
Dementia/therapy , Music Therapy , Dementia/rehabilitation , Humans , Severity of Illness IndexABSTRACT
We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-beta-lactamase (VIM-1) and an extended-spectrum beta-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Bacteremia/drug therapy , Klebsiella Infections/drug therapy , Klebsiella pneumoniae/drug effects , Minocycline/analogs & derivatives , beta-Lactamases/biosynthesis , Aged , Colistin/therapeutic use , Drug Synergism , Drug Therapy, Combination , Humans , Klebsiella pneumoniae/enzymology , Male , Microbial Sensitivity Tests , Microbial Viability , Minocycline/therapeutic use , TigecyclineABSTRACT
OBJECTIVES: In vitro studies have shown good activity of linezolid against Mycobacterium tuberculosis, including multidrug-resistant strains. However, clinical experience with linezolid in tuberculosis is scarce. METHODS: We report our clinical experience with five consecutive patients with multidrug-resistant tuberculosis infection treated with combination regimens that included linezolid. RESULTS: Two patients had multidrug-resistant Mycobacterium bovis infection, with resistance to 12 antituberculous agents (one of them with HIV co-infection and <50 CD4 cells/mm(3)). The other three patients were infected by multidrug-resistant M. tuberculosis strains, with resistance to all first-line drugs and other second-line drugs. All patients received linezolid in combination with thiacetazone, clofazimine or amoxicillin/clavulanate. Susceptibility tests showed linezolid MIC values < or =0.5 mg/L against all tuberculosis strains tested (standard proportion method, Middlebrook agar 7H10). In all cases, tuberculosis cultures from respiratory samples were sterile after 6 weeks of therapy. Three patients have clinical and microbiological cure of tuberculosis with a combination regimen with linezolid (range: 5-24 months). One patient was lost to follow-up at month 5. The remaining patient has completed 11 months of therapy and is still on treatment. Four patients developed anaemia and needed blood transfusions. In two of these patients, the linezolid daily-dose (600 mg twice a day) was successfully reduced to 50% (300 mg twice a day) to decrease toxicity while maintaining efficacy. Peripheral neuropathy (two patients) and pancreatitis (one patient) were other adverse events observed during linezolid treatment. CONCLUSIONS: In our experience, linezolid has been a valid alternative drug in the management of multidrug-resistant tuberculosis. The prolonged use of linezolid is frequently associated with toxicity, mainly anaemia and peripheral neuropathy, that requires special management.