ABSTRACT
BACKGROUND/OBJECTIVE: Terpenoids demonstrate pharmacologic activities that address important mechanisms underlying the pathogenesis of several cutaneous diseases. This review evaluated clinical trials of dermatology-specific terpenoid-based treatments. METHODS: PubMed and EMBASE were reviewed on July 8, 2014. Two independent reviewers reviewed studies for inclusion and extracted data for studies meeting eligibility criteria. References were manually reviewed for potentially relevant studies. RESULTS: The search yielded 437 unique abstracts, of which 13 met inclusion and exclusion criteria. High-quality evidence suggests that ingenol mebutate may be effective in treating actinic keratosis. Limited available evidence indicates that terpenoids may benefit patients with nonmelanoma skin cancers, cutaneous candidiasis, hyperpigmentation, photoaging, and wounds. CONCLUSIONS: Terpenoids appear to be effective in treating specific dermatologic conditions. However, additional rigorously conducted clinical trials are needed to better ascertain efficacy.
Subject(s)
Skin Diseases/drug therapy , Terpenes/therapeutic use , Humans , Randomized Controlled Trials as TopicABSTRACT
BACKGROUND: Overexposure to solar radiation is a major contributor to skin cancer development and premature skin aging. Botanical extracts and vitamins may represent novel photoprotective agents. OBJECTIVE: We sought to systemically review clinical evidence for the use of botanically derived agents and vitamins as photoprotective agents. METHODS: We systematically searched Embase and PubMed databases. Two independent reviewers reviewed abstracts for inclusion. Additional relevant studies were identified by a manual review of reference lists. Data from eligible studies were extracted independently and discrepancies were resolved by consensus. RESULTS: A total of 51 studies met inclusion criteria. Limited available evidence indicates that several botanical agents and vitamins in topical or oral forms may have promising photoprotective effects. However, generalizability of results is limited by small sample sizes. CONCLUSION AND RELEVANCE: Botanical extracts and vitamins may add to the armamentarium of sun-protective agents. Additional high-quality trials are needed to strengthen support for their use.
Subject(s)
Radiation-Protective Agents/administration & dosage , Skin Aging , Vitamins/therapeutic use , Humans , Skin/pathologyABSTRACT
BACKGROUND: Polyphenol phytochemicals demonstrate biological properties in vitro and in vivo that have led to the development of novel treatments for certain dermatological conditions. OBJECTIVE: We sought to provide clinicians with an overview of clinical trials evaluating the effectiveness of polyphenol-based therapies and highlight novel treatments and the evidence available supporting their use. METHODS: PubMed and Embase databases were systematically searched to 4 July 2014. Two independent reviewers reviewed published abstracts for inclusion. References were also manually searched for relevant studies. Data were extracted independently from eligible studies and discrepancies were adjudicated by consensus. RESULTS: Our search yielded 356 unique abstracts, of which 17 studies met inclusion and exclusion criteria. Polyphenols were used in topical and oral forms. High-quality evidence suggests that green tea polyphenols may be effective in treating anogenital warts. Limited available evidence indicates that polyphenols may also benefit patients with alopecia, acne vulgaris, fungal infections, hyperpigmentation or photoaged skin. CONCLUSIONS AND RELEVANCE: Evidence-based knowledge regarding the effectiveness, indications and side effects of polyphenol-based phytochemicals is needed as their clinical use increases within dermatology. We qualitatively conclude that polyphenols may be effective in treating certain dermatological conditions. Additional rigorously conducted clinical trials are needed to further evaluate efficacy.
Subject(s)
Dermatologic Agents/therapeutic use , Polyphenols/therapeutic use , Skin Diseases/drug therapy , HumansABSTRACT
Nail involvement in psoriatic diseases causes significant physical and functional disabilities. Evaluating, measuring, and treating nail involvement is important in improving the health outcomes and quality of life among patients with psoriasis and psoriatic arthritis (PsA). We performed a systematic analysis of the literature on nail psoriasis to help inform an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).