ABSTRACT
We report a 70-year-old patient with sarcoidosis associated with psoriasis vulgaris. He had a nodule on the medial lower lid of his right eye. Oral corticosteroid for the sarcoid lesions and oral PUVA for psoriasis were employed. The cutaneous lesion disappeared within two months after starting the therapy. No relapse of sarcoidosis has been seen for eight years. The association of sarcoidosis with psoriasis has been previously reported; however, it is still unclear whether this association coincidental or meaningful.
Subject(s)
Granuloma, Giant Cell/diagnosis , Psoriasis/diagnosis , Sarcoidosis, Pulmonary/diagnosis , Aged , Diagnosis, Differential , Eyelids , Glucocorticoids/therapeutic use , Granuloma, Giant Cell/complications , Granuloma, Giant Cell/drug therapy , Granuloma, Giant Cell/pathology , Humans , Male , PUVA Therapy , Prednisolone/therapeutic use , Psoriasis/complications , Psoriasis/drug therapy , Psoriasis/pathology , Sarcoidosis, Pulmonary/complications , Sarcoidosis, Pulmonary/drug therapy , Sarcoidosis, Pulmonary/pathology , Skin Diseases/complications , Skin Diseases/diagnosis , Skin Diseases/drug therapy , Skin Diseases/pathologyABSTRACT
A 20-year-old man presented with microcytic hypochromic anemia (hemoglobin: 9.3 g/dl, MCV: 82.0 fl, MCHC: 29.5 g/dl) and dimorphism RBCs in circulating blood (RDW: 26.8%). Ringed sideroblasts accounted for 29.5% of bone marrow erythroblasts. Iron overload was also observed. Because the patient had a clear family history of anemia, he was given a diagnosis of X-linked sideroblastic anemia. The activity of delta-aminolevulinic acid synthase (ALAS) in bone marrow erythroblasts was low. However, we did not detect mutation of the gene for ALAS. The patient has responded well to a treatment regimen consisting of oral vitamin B6, Fe-chelation therapy, and phlebotomy.
Subject(s)
Anemia, Sideroblastic/genetics , Genetic Linkage , X Chromosome , Adult , Humans , Male , PedigreeABSTRACT
A 66-year-old woman who lived on Tokunoshima Island, a small and remote southern island of the Japanese archipelago, had suffered from chromomycosis for more than 30 years and presented with a tumor-like growth on the posterior crural region of his right leg. Fonsecaea pedrosoi was identified as the pathogen from its growth pattern and micromorphological characteristics. The patient was successfully treated with 5-fluorocytosine, itoraconazole, and topical thermotherapy.