Subject(s)
Hysteroscopy/adverse effects , Intraoperative Complications/etiology , Nitroglycerin/administration & dosage , Pulmonary Edema/etiology , Respiratory Distress Syndrome/etiology , Acute Disease , Female , Humans , Intraoperative Complications/drug therapy , Medical Illustration , Middle Aged , Pulmonary Edema/drug therapy , Respiratory Distress Syndrome/drug therapy , Syndrome , Therapeutic Irrigation/adverse effects , Transurethral Resection of Prostate , Uterine Myomectomy/adverse effectsABSTRACT
We investigated three issues with respect to the long-term serial recall of adults. First, retention interval was manipulated to obtain uncontaminated measures of long-term serial recall. Second, we compared serial recall of concrete and abstract nouns to determine how these materials might interact with various learning strategies over time. Third, control group participants were asked to describe the learning strategies used, allowing a comparison of technical mnemonic techniques with the spontaneously generated strategies of adults. We found that the delayed recall performance of participants who spontaneously used organizational or imagery-based strategies was comparable to that of those instructed in the method of loci and pegword technique. Word concreteness did not interact with any other variable. These results are discussed with regard to their implications for serial learning in educational settings.
Subject(s)
Memory , Serial Learning , Adult , Female , Humans , Imagination , Male , Mental Recall , Teaching/methods , Word Association TestsABSTRACT
An isotopic exchange method was used to label lipiodol with 131I. The labelling efficiency was > 92.5%, and the radiochemical purity of [131I]lipiodol was above 98% as determined by ITLC. The influencing factors e.g. the heating temperature, reaction time, pH and storage conditions were studied and the optimum conditions were determined. In a pilot study injecting [131I]lipiodol for the treatment of hepatoma, about 70% of hepatoma patients had a response to the treatment with a reduction of alpha-fetoprotein and decrease of hepatoma sizes. The overall median survival was 9 months (range 2-17 months).
Subject(s)
Carcinoma, Hepatocellular/radiotherapy , Iodine Radioisotopes/therapeutic use , Iodized Oil/therapeutic use , Liver Neoplasms/radiotherapy , Carcinoma, Hepatocellular/metabolism , Humans , Iodized Oil/pharmacokinetics , Isotope Labeling , Liver Neoplasms/metabolism , Pilot ProjectsABSTRACT
High-dose infusions of methotrexate with citrovorum factor rescue were evaluated in 27 patients with advanced recurrent breast cancer who had previously been treated with various Adriamycin-containing regimens. Eight of 27 patients (29%) achieved objective tumor regression with a median duration of response of 26 weeks. Nineteen patients had previously received standard doses of methotrexate (less than 50 mg/m2/dose), while eight patients had had no prior exposure to methotrexate. The response rates observed in these two groups of patients were similar. Except for two drug-related deaths, toxic effects were acceptable. Myelosuppression was mild, transient, and noncumulative. Gastrointestinal toxic effects did not appear to be dose-related and were mild in most instances. Central nervous system dysfunction with lethargy, fatigability, confusion, and disorientation was the most significant toxic effect of this high-dose methotrexate therapy and was observed in six (22%) of the patients. In two patients treatment with this program was discontinued because of the development of renal dysfunction. High-dose methotrexate with citrovorum factor rescue appears to be an effective regimen in patients with advanced refractory breast cancer. However, in view of the enormous cost necessitated by this treatment approach, we do not feel further studies would be worthwhile.