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1.
Thorac Cardiovasc Surg ; 69(5): 461-465, 2021 Aug.
Article in English | MEDLINE | ID: mdl-33075824

ABSTRACT

As part of an institutionally driven holistic concept, named the "360-degree approach," all established surgical access routes -full sternotomy, partial upper sternotomy, and right anterolateral thoracotomy using the second interspace-are supported. The surgical toolbox now is completed by adding a further approach: through a 5- to7-cm skin incision in the right anterior axillary line, the third interspace is used for a minimally invasive aortic valve surgery providing striking exposition of the aortic valve and resulting in superior cosmetics with nearly no visible scars. The choice for the one or other method is institutionally driven and based on risk profiles, as well as anatomical and physiognomic considerations.


Subject(s)
Aortic Valve Stenosis/surgery , Aortic Valve/surgery , Cicatrix/prevention & control , Heart Valve Prosthesis Implantation , Aortic Valve/diagnostic imaging , Aortic Valve Stenosis/diagnostic imaging , Cicatrix/etiology , Clinical Decision-Making , Heart Valve Prosthesis , Heart Valve Prosthesis Implantation/adverse effects , Heart Valve Prosthesis Implantation/instrumentation , Humans , Patient Selection , Treatment Outcome
2.
Thorac Cardiovasc Surg ; 62(7): 569-74, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24756483

ABSTRACT

INTRODUCTION: The impact of omega-3 polyunsaturated fatty acids (PUFAs) for prevention of atrial fibrillation (AF) is still part of a lively debate. The present study evaluates the impact of orally administered omega-3 ethyl ester concentrate (omega-3 PUFA) on postoperative onset of AF in patients with recent myocardial infarction (≤ 3 months) undergoing isolated coronary artery bypass grafting (CABG). Patients and METHODS: The study included a total of 198 patients with recent (≤ 3 months) myocardial infarction. The treatment group consisted of 99 prospectively and randomly assigned patients. A matched control group was generated out of the entirety of patients undergoing isolated CABG during the same time period, being not treated with omega-3 PUFA. Primary endpoint was onset of postoperative AF. Patients of the treatment group received a daily dose of 2 g omega-3 PUFA, initiated 5 days before surgery. Effective serum levels were confirmed by laboratory testing. RESULTS: Patients of the treatment group had less frequently postoperative AF (treatment: 31.3% vs. control: 48.0%; p = 0.017). The reduction in relative risk was 34.8% in the treatment group, which conforms a number needed to treat (NNT) of 6.0 patients. A more pronounced effect with a NNT of 4.1 was observed in patients ≤ 70 years (p = 0.007). Besides, patients of the treatment group had a shorter intensive care unit stay (p = 0.001) and suffered less frequently from impaired wound healing by trend (p = 0.063). One patient out of treatment group and two out of control group died during hospital stay (p = 1.000). CONCLUSION: Preoperative administration of 2 g omega-3 PUFA reduces incidence of postoperative AF in patients with recent (≤ 3 months) myocardial infarction undergoing isolated CABG.


Subject(s)
Atrial Fibrillation/prevention & control , Coronary Artery Bypass/adverse effects , Fatty Acids, Omega-3/administration & dosage , Myocardial Infarction/surgery , Postoperative Complications/prevention & control , Administration, Oral , Aged , Atrial Fibrillation/etiology , Atrial Fibrillation/physiopathology , Dose-Response Relationship, Drug , Electrocardiography , Female , Follow-Up Studies , Heart Rate/drug effects , Humans , Incidence , Male , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Prospective Studies , Time Factors , Treatment Outcome , United States/epidemiology
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