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1.
Zhongguo Zhen Jiu ; 44(3): 251-254, 2024 Mar 12.
Article in English, Chinese | MEDLINE | ID: mdl-38467497

ABSTRACT

OBJECTIVES: To observe the effect of motor evoked potential (MEP)-oriented scalp acupuncture combined with transcranial magnetic stimulation (TMS) on limb motor ability in patients with ischemic stroke hemiplegia. METHODS: A total of 60 patients with ischemic stroke hemiplegia were randomized into an observation group and a control group, 30 cases in each one. In addition to the medication treatment of internal medicine and comprehensive training of hemiplegic limbs, MEP-oriented scalp acupuncture combined with TMS was applied in the observation group, conventional scalp acupuncture at bilateral anterior oblique line of parietal and temporal regions combined with TMS was applied in the control group. The treatment was given once a day, 5 days a week for 4 weeks totally in the two groups. Before and after treatment, the scores of Fugl-Meyer assessment (FMA), modified Ashworth scale (MAS) and modified Barthel index (MBI) were observed in the two groups. RESULTS: After treatment, the FMA and MBI scores were increased compared with those before treatment in the two groups (P<0.001), and the FMA and MBI scores in the observation group were higher than those in the control group (P<0.05). After treatment, the MAS scores of upper and lower limbs in the observation group were decreased compared with those before treatment (P<0.01, P<0.001), the MAS score of lower limb in the control group was decreased compared with that before treatment (P<0.05). CONCLUSIONS: MEP-oriented scalp acupuncture combined with TMS can effectively improve the limb motor ability, daily living ability and limb spasticity in patients with ischemic stroke hemiplegia.


Subject(s)
Acupuncture Therapy , Ischemic Stroke , Stroke Rehabilitation , Stroke , Humans , Stroke/complications , Stroke/therapy , Hemiplegia/etiology , Hemiplegia/therapy , Transcranial Magnetic Stimulation , Scalp , Evoked Potentials, Motor , Treatment Outcome , Upper Extremity
2.
Cancer Lett ; 367(1): 18-25, 2015 Oct 10.
Article in English | MEDLINE | ID: mdl-26187782

ABSTRACT

The role of reactive oxygen species (ROS) in cancer cells has been intensively studied for the past two decades. Cancer cells mostly have higher basal ROS levels than their normal counterparts. The induction of ROS has been shown to be associated with cancer development, metastasis, progression, and survival. Various therapeutic approaches targeting intracellular ROS levels have yielded mixed results. As widely accepted dietary supplements, antioxidants demonstrate both ROS scavenging ability and anti-cancer characteristics. However, antioxidants may not always be safe to use since excessive intake of antioxidants could lead to serious health concerns. In this review, we have evaluated the production and scavenging systems of ROS in cells, as well as the beneficial and harmful roles of ROS in cancer cells. We also examine the effect of antioxidants in cancer treatment, the effect of combined treatment of antioxidants with traditional cancer therapies, and the side effects of excessive antioxidant intake.


Subject(s)
Antineoplastic Agents/therapeutic use , Antioxidants/therapeutic use , Neoplasms/drug therapy , Oxidative Stress/drug effects , Reactive Oxygen Species/metabolism , Animals , Antineoplastic Agents/adverse effects , Antioxidants/adverse effects , Humans , Neoplasms/metabolism , Neoplasms/pathology , Oxidation-Reduction , Signal Transduction/drug effects , Treatment Outcome
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