Research progress in prevention and treatment of radiation-induced intestinal injury by traditional Chinese medicine active components / 中国中药杂志

Radiation-induced intestinal injury(RIII), a common complication of radiotherapy for pelvic malignancies, affects the quality of life and the radiotherapy efficacy for cancer. Currently, the main clinical approaches for the prevention and treatment of RIII include drug therapy, hyperbaric oxygen therapy, and surgical treatment. Among these methods, drug therapy is cost-effective. Traditional Chinese medicine(TCM) containing a variety of active components demonstrates mild side effects and good efficacy in preventing and treating RIII. Studies have proven that TCM active components, such as flavonoids, terpenoids, phenylpropanoids, and alkaloids, can protect the intestine against RIII by inhibiting oxidative stress, regulating the expression of inflammatory cytokines, modulating the mitochondrial apoptosis pathway, adjusting intestinal flora, and suppressing cell apoptosis. These mechanisms can help alleviate the symptoms of RIII. The paper aims to provide a theoretical reference for the discovery of new drugs for the prevention and treatment of RIII by reviewing the literature on TCM active components in the last 10 years.

Therapeutic effect of Yaotongning Capsules and thunder-fire moxibustion in treatment of 40 cases of lumbar disc herniation with cold and blood-stasis syndrome / 中草药

Objective: To explore the clinical efficacy effect of Yaotongning Capsules combined with thunder-fire moxibustion on lumbar disc herniation (LDH). Methods: A total of 80 LDH patients who met the inclusion criteria were randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with Yaotongning Capsules combined with thunder-fire moxibustion, and the control group was treated with ibuprofen sustained release capsule combined with thunder-fire moxibustion. VAS score, JOA score, ODI score and clinical efficacy were compared. Results: VAS scores and ODI scores of the two groups after treatment were lower than those before treatment (P < 0.05), and the JOA score was higher than that before treatment (P < 0.05); After treatment, the VAS score and ODI score in the observation group were lower than those in the control group (P < 0.05); After treatment, the JOA score was higher than that in the control group (P < 0.05). The clinical efficacy of the observation group was better than that of the control group (P < 0.05). Conclusion: The clinical treatment of Yaotongning Capsules combined with thunder-fire moxibustion treating LDH can obviously alleviate the pain symptoms and improve the daily function of the patients, which is worthy of further clinical application.