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Objective:To analyze the medication rules in the ancient book Pu Ji Fang for the external treatment of acne based on data mining method. Methods:By screening out the methods of treating acne externally in Pu Ji Fang and establishing a standardized medical record database, this paper adopted the web version of Ancient and Modern Medical Record Cloud Platform to calculate the frequency, properties, flavors, and meridians of those medicines, and conduct cluster analysis by using IBM SPSS Modeler 18.0 software to analyze the association rules. Results:A total of 87 prescriptions were selected, including 164 kinds of Chinese materia medica, among which. Radix Angelicae, Ligusticum Wallichii, Rhizoma Typhoni and lead powder are frequently appeared. The properties of those medicines are mainly warm, cold and mild; the flavors of those medicines are mainly spicy, acrid, sweet and bitter, and the meridians mainly belongs to lung, spleen, stomach and liver meridians. The medical pair and group with the strongest associationion are Ligusticum Wallichii- Radix Angelicae and Rhizoma Typhonii- Radix Angelicae- Ligusticum Wallichii. Those freuently appeared medicines could be grouped into three categories. The paste dosage that was frequently appeared has strong correlation with tallow, mercury and lead powder, while the powder dosage that was frequenctly appeared has strong correlation with Angelica Dahurica, Radix Saponicae, Gleditsia sinensis, Radices Ligustici Sinensis and Ligusticum Wallichii. Conclusions:The application of data mining method could preliminarily reveal the medication rules of Pu Ji Fang for the external treatment of acne. The main treatment method is XinSanFaYue. The three categories of Chinese materia medica are used to treat the syndrome of asthenic habitus attacked by exogenous pathogenic factors, exterior attacked by wind heat and hot blood stasis respectively, showing the rules of treating acne externally before Ming Dynasty and providing references for the clinical treatment of acne.
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Objective:To collect and analyze the evaluation index of infertility treated by Traditional Chinese Medicine (TCM), which will lay a foundation for the establishment of the core index and evaluation index system of TCM treating infertility.Methods:By retriving the published literatures of randomized controlled trials of infertility treated by TCM in the database of CNKI, VIP, Wanfang, SinoMed, PubMed and Cochrane Library from January 1, 2011 to December 31, 2020, and after the screening according to the creteria of inclusion and exclusion, this paper analyzed the normal indexes of infertility and the pathogenic indexes of TCM.Results:A total of 95 RCTs were included, including 9 069 patients aged between 20-39 years old. The average sample size of each RCT study was 95, involving 78 evaluation criteria. The highest frequency of use was the total effective rate, etiological-index analysis found that the general indicators of infertility such as the total effective rate, pregnancy rate, TCM syndrome scores,and common etiological factors such as LH, FSH are the characteristic indicators.Conclusion:There are many problems in the evaluation indexes of clinical trials of treating infertility by TCM, such as great differences in number and not standardized usage. It is necessary to carry out research on the construction of core indicator and evaluation indicator systems of infertility according to different etiologies.
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Objective:To explore the similarities and differences between Opening Xuanfu therapy and Qingreliangxue therapy in the treatment of psoriasis based on the Network Pharmacology.Methods:The active ingredients and protein targets of the representative Traditional Chinese Medicine contained in drugs Qingreliangxue therapy and Opening Xuanfu therapy were screened out by Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), Encyclopedia of Traditional Chinese Medicine (ETCM) and Traditional Chinese Medicine Integrated Database (TCMID). The Targets of psoriasis were collected by GeneCards and OMIM databases. The intersections of component targets and disease targets were obtained by Venny 2.1.0, and then the protein-protein interaction (PPI) was constructed by String Platform and Cytoscape 3.9.0 to screen out the key targets in the two therapies that could treat psoriasis. GO functional enrichment analysis and KEGG pathway enrichment analysis were performed via the Metascape platform. The potential advantages of opening Xuanfu therapy in the treatment of psoriasis comorbidities are found out by using Venny and Cytoscape to compare the differences and visually analyze the above results.Results:8 ingredients are with the same effect and 73 ingredients are different in these two therapies. There are 43 identical and 15 different potential targets in these two therapies..10 representative key targets in each of the two therapies were obtained by PPI network analysis, including 7 identical key targets, namely HIF1A, MYC, CCND1, FOS, IL6, PPARG, NFKBIA, and 6 different targets. Go enrichment results show that there are 10 same biological processes in the first 20 articles of the two the therapies, including the response to external stimuli, the regulation of cell adhesion, the response to steroid hormone, the response to injury, the negative regulation of cell differentiation, the response to growth factors and metabolism of reactive oxygen species. KEGG enrichment results of the first 20 pathways in the two therapies show that there are 8 same pathways, including cancer-related pathways, fluid shear stress and atherosclerosis, MAPK signaling pathway, p53 signaling pathway, transcriptional imbalance in cancer and cholinergic synapse.Conclusion:Qingreliangxue therapy in the treatment of psoriasis mainly plays the role of antioxidant, anti-inflammatory, anti-proliferative and immune-regulating effects. The Opening Xuanfu therapy in the treatment of psoriasis mainly plays the role of regulating lipid metabolism, anti-inflammatory, regulating cell apoptosis, anti-oxidation, anti-proliferation, regulating angiogenesis and abnormal morphology.
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Germany owns the largest herbal market in Europe and has the world's leading R&D capabilities for herbal medicine products. Chinese herbal medicine (CHM) spreaded to Germany hundreds of years ago. Since the beginning of the 20th century, China and Germany have signed a series of agreements to support traditional medicine cooperation, and the exchange of herbs between China and Germany has become more frequent, bringing opportunities for CHM to enter into Germany. In recent years, China and Germany have gained progress in the fields of CHM research and trade, etc. However, there are differences in the understanding of herbal medicines, quality standard evaluation, usage, and medication rules between the two countries. By doing SWOT analysis of the development of CHM in Germany, this paper suggested to promote Sino-German medical exchanges and build a community of common health for mankind through strengthening the clinical application of CHM, finding new ways of CHM entering into German market, and building an international talent team of traditional Chinese medicine.
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The processing of traditional Chinese medicine(TCM) is a traditional pharmaceutical technology,which meets the development demand of the treatment based on syndrome differentiation of TCM. It is one of the important means to guarantee the quality of Chinese medicine and improve the clinical efficacy of TCM. Medical institutions of traditional Chinese medicine should take the advantages and characteristics of traditional Chinese medicine as the foundation, vigorously carry out processing technology for traditional Chinese medicine, rich clinical drug varieties of traditional Chinese medicine, and develop such characteristics of TCM as treatment based on syndrome differentiation and individualized drug treatment. The processing of temporary prescriptions is one of the important means to reflect the characteristics of TCM, and it is of great significance to improve the curative effect of TCM. Based on working practice, this paper summarized the development current status, significance, technical standards and samples of processing variety and methods etc in order to provide thoughts for the processing technology of temporary prescriptions in medical institutions.
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Objective:To understand the development reality of pastes in Hubei province through the investigation of paste busi-ness in 2013. Methods:Issued by Hubei provincial administration of traditional Chinese medicine, a questionnaire investigation was a-dopted in the study. The implementation, usage amount, scope, composition of the users, price, technical personnel and propaganda of pastes were investigated and statistically analyzed in 91 TCM, integrated Chinese and western and national hospitals in our province. Results:The business conduction rate of pastes in Hubei province was nearly 61. 54% in 2013 with the production of approximately 45,000 batches and the technical personnel of 1 538. The paste business created great economic value of 0. 48 million yuan in 2013 with strengthened propaganda. However, the brand building was slightly weak. Conclusion:The business of pastes in Hubei province has developed rapidly and still shows great development potential.