ABSTRACT
The in vivo formation of dioxins from chemical precursors was investigated in rats. Sprague-Dawley rats were fed pentachlorophenol or a predioxin in peanut oil for 14 days. Mass balance calculations indicated that pentachlorophenol was not converted to dioxins; however, the predioxin, nonachloro-2-phenoxyphenol, was converted to OCDD. Conversion of the predioxin ranged from 0.5% to 153% and depended on the amount of predioxin and OCDD present in the diet. The analytical procedures used for sample preparation did not appear to cause conversion of the predioxin to OCDD. The mechanism for biological conversion may be enzymatic or spontaneous.
Subject(s)
Polychlorinated Dibenzodioxins/analogs & derivatives , Animals , Diet , Dioxins/administration & dosage , Dioxins/metabolism , Peanut Oil , Pentachlorophenol/administration & dosage , Pentachlorophenol/metabolism , Plant Oils/administration & dosage , Polychlorinated Dibenzodioxins/metabolism , Rats , Rats, Sprague-DawleyABSTRACT
Seven sheep metabolites of crufomate (4-t-butyl-2-chlorophenyl methyl methylphosphoramidate) were characterized as glucuronide conjugates by interpretation of mass spectral data obtained from ths of the methyl esters.