Magnetic targeting cobalt nanowire-based multifunctional therapeutic system for anticancer treatment and angiogenesis.

In order to improve the anticancer therapeutic efficacy and postoperative recovery efficacy, the novel anticancer therapeutic system should have the ability to promote angiogenesis after anticancer therapy besides the excellent anticancer therapeutic efficacy. We present herein a magnetic targeting multifunctional anticancer therapeutic system based on cobalt nanowires (CoNWs) for anticancer therapy and angiogenesis. Magnetic characterization shows that the CoNWs can be concentrated in desired locations under the external magnetic field, which is favorable for anticancer target therapy. Besides, drug loading/release characterization reveals that the CoNWs interact with doxorubicin (DOX) by electrostatic interaction, and accordingly form a composite which can release DOX with temperature increase under near-infrared light (NIR) treatment. And anticancer test reveals that the nanowires loaded with the DOX (CoNWs-DOX) can produce an effective chemo-photothermal synergistic therapeutic effect against murine breast cancer cell lines (4T1) and human osteosarcoma cell lines (MG63) under NIR treatment. Furthermore, angiogenesis assessment reveals that the released cobalt ion from the nanowires can significantly enhance the angiogenesis efficacy after cancer treatment. These results suggest that the constructed anticancer therapeutic system provides a promising multifunctional platform for cancer treatment and postoperative recovery.

Cobalt nanowire-based multifunctional platform for targeted chemo-photothermal synergistic cancer therapy.

Cobalt nanowires (CoNWs) simultaneously possessing advantages in photothermal effect, targeting drug delivery and photoacoustic imaging property are hopefully promising strategies to further improve the treatment efficiency and reduce the side effects of cancer chemotherapy. Herein, a unique cobalt-based structure decorated with graphene oxide (GO) and polyethylene glycol (PEG) is fabricated through a facile approach. The resultant nanohybrids show relatively low cytotoxicity, favorable biocompatibility as well as inherit the outstanding properties of cobalt. Moreover, CoNWs decorated with GO and PEG (CoNWs-GO-PEG) can load therapeutic drug molecules (e.g., doxorubicin, DOX) with a high drug loading capacity (992.91 mg/g), and simultaneously they are responsive to pH, NIR (near-infrared) irradiation and magnetism stimulation. Accordingly, CoNWs-GO-PEG-DOX shows the satisfactory effect of eliminating cancer cells with synergistic chemo-photothermal therapy in vitro. Current work provides a solid demonstration of the potential of CoNWs-GO-PEG for serving as a targeted antitumor agent in synergistic chemo-photothermal therapy.