ABSTRACT
Objective: To explore the influencing factors related to thyroid carcinoma. Methods: Matched by sex, age and original residential areas, 659 pairs of cases and controls were recruited and studied. Methods including both single factor analysis and multivariate conditional logistic regression analysis were carried out to identify the influencing factors. Results: Multivariate conditional logistic regression analysis showed that higher education, being diabetic, alcohol intake, tea drinking, occupational physical activity and the frequency of eating fishes/eggs etc., were potentially protective to thyroid carcinoma. Depression, personal history of CT examination and less salt intake seemed to be risk factors on thyroid carcinoma. For males, factors as alcohol intake, tea drinking, occupational physical activity and frequent egg-eating appeared protective. For females, higher education, diabetes, tea drinking, occupational physical activity, frequent consumption of fishes/eggs, short duration of menstruation appeared as possibly protective. Conclusion: Higher education, diabetes, alcohol intake, tea drinking, occupational physical activity, frequent consumption of fishes/eggs, depression, personal history of CT examination and less salt intake served as potential influencing factors to thyroid carcinoma.
Subject(s)
Alcohol Drinking , Feeding Behavior , Thyroid Neoplasms/epidemiology , Animals , Case-Control Studies , China/epidemiology , Female , Male , Risk Factors , Tea , Thyroid Neoplasms/etiologyABSTRACT
Ether extracts of 1693 Chinese medicinal herbs and plants from 268 families were studied for the induction of Epstein-Barr viral (EBV) early antigen (EA) expression in the Raji cell line. Fifty-two from 18 families were found to have inducing activity. Twenty-five and seven of them were from Euphorbiaceae and Thymelaeaeeae, respectively. Some of them, such as Croton tiglium, Euphorbia kansui, Daphne genkwa, Wikstroemia chamaedaphne, Wikstroemia indica, Prunus mandshurica Koehne and Achyranthes bidentata are commonly used drugs. The significance of these herbs in the activation of EBV in vivo and their relation to the development of nasopharyngeal carcinoma were discussed.
Subject(s)
Antigens, Viral/biosynthesis , Drugs, Chinese Herbal/pharmacology , Herpesvirus 4, Human/metabolism , Antigens, Viral/drug effects , Cell Line , Herpesvirus 4, Human/drug effects , Herpesvirus 4, Human/immunologySubject(s)
Antigens, Viral/biosynthesis , Plants, Medicinal , Cells, Cultured , China , Humans , Plant Extracts/pharmacologyABSTRACT
Ether extracts of 495 Chinese medicinal herbs from 106 families were studied for Epstein-Barr virus (EBV) early antigen (EA) induction in the Raji cell system. 15 herbs from 10 families were found to have inducing activity. Water extracts of the same herbs also had inducing activity, but it was not as strong. The significance of these herbs in the activation of EBV in vivo and their relation to the development of nasopharyngeal carcinoma are discussed. No EA-inducing activity was found in 73 samples of 14 different foods tested.
Subject(s)
Antigens, Viral/biosynthesis , Herpesvirus 4, Human/growth & development , Plants, Medicinal , Virus Activation/drug effects , Carcinoma/etiology , Cell Line , China , Food , Herpesvirus 4, Human/immunology , Humans , Nasopharyngeal Neoplasms/etiology , Plant Extracts/pharmacologyABSTRACT
The purpose of this study was to determine the antiviral effect of human leukocyte interferon on Epstein-Barr virus (EBV) viral capsid antigen (VCA) and early antigen (EA) induction in B95-8 and Raji cells. Interferon made at the Institute of Virology, Beijing, and that provided by Dr. Cantell gave unexpected results. Both interferon preparations markedly enhanced spontaneous VCA and EA induction in B95-8 cells and EA induction in Raji cells simultaneously treated with croton oil and n-butyrate. Interferon treatment alone had no effect on EA induction in Raji cells. Thus, the effect of interferon on EA and VCA induction was related to the type of EBV infection, i.e., productive or latent. The enhancing activity of interferon could only be partially inhibited by retinoid 7901. It is suggested that the mechanism for enhancement of EA induction by interferon is different from that of EA induction in Raji cells by croton oil and n-butyrate.