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Immunol Allergy Clin North Am ; 37(3): 585-595, 2017 08.
Article in English | MEDLINE | ID: mdl-28687111

ABSTRACT

Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease that can lead to debilitating and dangerous angioedema episodes associated with significant costs for individuals and society. The burden of treatment must be addressed regarding medication administration difficulties, treatment complications, and adverse side effects. New therapies are being investigated and may offer solutions to these challenges. This article reviews the emerging therapeutic options for the treatment of HAE.


Subject(s)
Angioedemas, Hereditary/therapy , Angioedemas, Hereditary/diagnosis , Angioedemas, Hereditary/etiology , Angioedemas, Hereditary/metabolism , Animals , Bradykinin/metabolism , Clinical Trials as Topic , Combined Modality Therapy , Complement C1 Inhibitor Protein/therapeutic use , Drug Discovery , Drug Evaluation, Preclinical , Factor XII/antagonists & inhibitors , Factor XII/metabolism , Histamine/metabolism , Humans , Signal Transduction , Treatment Outcome
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