1.
J Med Chem
; 20(1): 171-3, 1977 Jan.
Article
in English
| MEDLINE
| ID: mdl-833821
ABSTRACT
The preparation of 5-phenylbicyclo [3.3.1]nonan-2-one is described starting from the ketal of 4-phenyl-4-(2-carbethoxyethyl)cyclohexan-1-one. The ketone was then taken on to the butyrophenone derivatives of endo-and exo-5phenylbicyclo[3.3.1]nonyl-2-amine. CNS screening results of these compounds are described.
Subject(s)
Butyrophenones/chemical synthesis , Animals , Bridged Bicyclo Compounds , Butyrophenones/pharmacology , Drug Evaluation, Preclinical , Isomerism , Lethal Dose 50 , Mice , Seizures/chemically induced
2.
Arzneimittelforschung
; 24(9): 1248-56, 1974 Sep.
Article
in English
| MEDLINE
| ID: mdl-4479786
Subject(s)
Butyrophenones/chemical synthesis , Piperidines/chemical synthesis , Animals , Apomorphine/antagonists & inhibitors , Avoidance Learning/drug effects , Behavior, Animal/drug effects , Butyrophenones/pharmacology , Butyrophenones/toxicity , Catalepsy/chemically induced , Cats , Chlorpromazine/pharmacology , Drug Evaluation, Preclinical , Drug Synergism , Electroencephalography , Epinephrine/antagonists & inhibitors , Haloperidol/pharmacology , Hexobarbital/pharmacology , Humans , Hydrocarbons, Fluorinated/chemical synthesis , Hydrocarbons, Fluorinated/pharmacology , Hydrocarbons, Fluorinated/toxicity , Imipramine/antagonists & inhibitors , Lethal Dose 50 , Male , Methamphetamine/pharmacology , Mice , Motor Activity/drug effects , Pain/drug therapy , Piperidines/pharmacology , Piperidines/toxicity , Rats , Trifluperidol/pharmacology
3.
J Pharm Pharmacol
; 22(6): 393-404, 1970 Jun.
Article
in English
| MEDLINE
| ID: mdl-4396099