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1.
BMC Complement Med Ther ; 24(1): 60, 2024 Jan 27.
Article in English | MEDLINE | ID: mdl-38281005

ABSTRACT

BACKGROUND: Sensitive gag reflexes prevent dental patients from receiving appropriate treatment. Aromatherapy helps patients relax during dental procedures. However, the effect of aromatherapy on the gag reflex caused by the stimulation of the oral cavity is unknown. This study aimed to evaluate whether aromatherapy reduces gag reflexes during oral stimulation. METHODS: In this randomized, placebo-controlled, single-blind, crossover study, the gag reflexes of 24 healthy individuals (12 females and 12 males; mean age: 34.3 ± 9.5 years) were quantified. A standard saliva ejector was slowly guided down the participant's throat to determine the maximum tolerance of the gag reflex, and the insertion distance was measured to quantify the gag reflex. All individuals participated in an aromatherapy session with peppermint essential oil and a placebo session with distilled water. The gag reflex was quantified before (baseline) and after each session. Another measurement was performed using nitrous oxide/oxygen inhalation as a positive control. RESULTS: Gag reflex values significantly increased after aromatherapy with both peppermint essential oil and placebo compared to baseline values (paired t-test, P < 0.001 and P = 0.014, respectively). The gag reflex value also increased significantly during nitrous oxide/oxygen inhalation (paired t-test, P < 0.001). There was no significant difference in the increase rate of gag reflex values between the positive control and aromatherapy interventions, but it was significantly lower after the placebo intervention (repeated measures analysis of variance, P = 0.003; post-hoc test, P = 0.83 and P = 0.02). CONCLUSION: Aromatherapy with peppermint essential oil has the potential for reducing gag reflex during dental procedures. TRIAL REGISTRATION: The study was registered in the University hospital Medical Information Network Clinical Trials Registry under the code UMIN000050616 (approved 17/03/2023).


Subject(s)
Aromatherapy , Oils, Volatile , Male , Female , Humans , Young Adult , Adult , Oils, Volatile/pharmacology , Aromatherapy/methods , Cross-Over Studies , Mentha piperita , Nitrous Oxide , Single-Blind Method , Gagging/physiology , Gagging/prevention & control , Oxygen
2.
J Indian Prosthodont Soc ; 22(2): 188-194, 2022.
Article in English | MEDLINE | ID: mdl-36511030

ABSTRACT

Aims: The aim of this study is to see if microcurrent electrical stimulation on two acupoints, auricular and Hegus, can help patients prevent their gag reflex. Settings and Design: This was an in vivo cross-sectional study. Materials and Methods: Thirty patients were randomly assigned to three groups: A, B, or C, of ten patients present in each group. Group A and Group B undergone electroacupuncture (microcurrent electrical stimulation) using electroacupuncture device on auricular point and Hegus point (Li 4), respectively, for 1 min and Group C formed the placebo group, point Shou San Li (Li 10). The gag severity index and the gag prevention index were used to measure the gag reflex, which was done in two steps. Statistical Analysis Used: SPSS (SPSS Inc., Chicago IL, USA) version 24 software was used for statistical analysis. Paired t-test, one-way analysis of variance test, post hoc Bonferroni test was used to analyse and compare the data. Results: It was found that Point A and Point B were significantly effective in reducing the severity of gag reflex. Point C demonstrated insignificant results. In addition, Point B (Hegus [Li4]) is more effective than Point A (auricular) in controlling the gag reflex in patients within the set age group of 20-70 years of age. Conclusions: Microcurrent electrical stimulation is a useful adjuvant in the treatment of unfavorable gag reflexes during routine dental procedures. Point Hegus and point auricular acupuncture are both useful in decreasing the severity of gag reflex, with point Hegus being more effective than point auricular.


Subject(s)
Acupuncture, Ear , Gagging , Humans , Young Adult , Adult , Middle Aged , Aged , Cross-Sectional Studies , Gagging/prevention & control , Gagging/physiology , Acupuncture Points , Electric Stimulation
3.
J Endod ; 40(9): 1327-31, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25146012

ABSTRACT

INTRODUCTION: Pain and anxiety control is critical in dental practice. Moderate sedation is a useful adjunct in managing a variety of conditions that make it difficult or impossible for some people to undergo certain dental procedures. The purpose of this study was to analyze the sedation protocols used in 3 dental specialty programs at the Case Western Reserve University School of Dental Medicine, Cleveland, OH. METHODS: A retrospective analysis was performed using dental school records of patients receiving moderate sedation in the graduate endodontic, periodontic, and oral surgery programs from January 1, 2010, to December 31, 2012. Information was gathered and the data compiled regarding the reasons for sedation, age, sex, pertinent medical conditions, American Society of Anesthesiologists physical status classifications, routes of administration, drugs, dosages, failures, complications, and other information that was recorded. RESULTS: The reasons for the use of moderate sedation were anxiety (54%), local anesthesia failures (15%), fear of needles (15%), severe gag reflex (8%), and claustrophobia with the rubber dam (8%). The most common medical conditions were hypertension (17%), asthma (15%), and bipolar disorder (8%). Most patients were classified as American Society of Anesthesiologists class II. More women (63.1%) were treated than men (36.9%). The mean age was 45 years. Monitoring and drugs varied among the programs. The most common tooth treated in the endodontic program was the mandibular molar. CONCLUSIONS: There are differences in the moderate sedation protocols used in the endodontic, periodontic, and oral surgery programs regarding monitoring, drugs used, and record keeping.


Subject(s)
Anesthesia, Dental/methods , Conscious Sedation/methods , Specialties, Dental/education , Adolescent , Adult , Aged , Aged, 80 and over , Anesthesia, Local , Asthma/complications , Bipolar Disorder/complications , Child , Cohort Studies , Dental Anxiety/complications , Education, Dental, Graduate , Endodontics/education , Female , Gagging/physiology , Humans , Hypertension/complications , Hypnotics and Sedatives/administration & dosage , Male , Middle Aged , Monitoring, Physiologic/methods , Needles , Periodontics/education , Phobic Disorders/psychology , Retrospective Studies , Surgery, Oral/education , Young Adult
4.
Acta pediatr. esp ; 71(4): 99-103, abr. 2013. ilus
Article in Spanish | IBECS | ID: ibc-111835

ABSTRACT

Tradicionalmente, la introducción de la alimentación complementaria pasa por un periodo de alimentación triturada, hasta que el lactante adquiere las habilidades para tomar comida en trocitos. En la práctica, el momento de la introducción de alimentos no triturados se ha ido retrasando, lo que ha llevado a una mayor frecuencia de problemas en la alimentación en esa edad. La alimentación complementaria guiada por el bebé (baby-led weaning) se basa en que sea el propio lactante quien se alimenta llevándose la comida a la boca, en vez de ser alimentado con una cuchara por un adulto. En esta práctica, el lactante se incorpora pronto a la comida familiar y comparte su menú, manteniendo la lactancia materna. Algunos estudios observacionales de pequeño tamaño sugieren que esta técnica favorece los patrones de alimentación, aunque no se ha podido demostrar si se plasma en efectos beneficiosos para la salud. Su difusión surge a raíz de la recomendación de la Organización Mundial de la Salud de retrasar la introducción de la alimentación complementaria hasta los 6 meses, en un momento en que el lactante ha alcanzado hitos importantes en su desarrollo, lo que haría posible que se alimentara por sí mismo. Algunos de los aspectos contenidos en esta filosofía serían válidos para la mayoría de los lactantes, aunque es difícil aceptarlo en su radicalidad (oposición a las comidas con cuchara). Las principales dudas que se plantean respecto a esta técnica son saber si el lactante recibe suficiente variedad de nutrientes y en una cuantía suficiente (p. ej., el hierro), si existe riesgo de atragantamiento y si la técnica es aplicable en todos los niños. A fecha de hoy, parece importante que los pediatras conozcamos en qué consiste esta técnica de alimentación y podamos responder a las preguntas de los padres sobre su eficacia y seguridad(AU)


Usually complementary feedings include, at least temporar­ily, pureed foods or spoon foods until infant is able to grasp food and feed herself. In daily practice time for chewable foods has delayed is this is a cause of eating problems in late infancy. Baby-led weaning (BLW) is an alternative approach for introducing complementary foods that emphasises infant self-feeding rather than adult spoon-feeding. In this way infants early joins family meals and share familial menu. Some small observacional studies suggest that this approach enhances eating patterns, although benefits for health are still to be probed. Its diffusion is according to the recommendations from the WHO to delay complementary feedings till 6 months of age. Many of the considerations of these phylosophy could be applied to most infants, although it is difficult to agree in some radical aspects (opposition to pureed foods). Main unanswered questions are: do infants following BLW obtain sufficient nutrients, including energy and iron? Are iron deficiency, choking and growth faltering real concerns for those following BLW approach? Is the technique suitable for all infants? Up to date, it seems important that pediatricians know about BLW approach, its benefits and risks(AU)


Subject(s)
Humans , Male , Female , Infant , Infant Nutrition/standards , Infant Nutritional Physiological Phenomena/economics , Infant Nutritional Physiological Phenomena/standards , Supplemental Health/standards , Supplemental Health , Breast Feeding/methods , Breast Feeding/trends , Gagging/prevention & control , Gagging/physiology , Infant Nutritional Physiological Phenomena/physiology , Infant Nutrition/education
5.
Indian J Dent Res ; 22(4): 600-2, 2011.
Article in English | MEDLINE | ID: mdl-22124062

ABSTRACT

Gagging is a frequent impediment to the performance of dental procedures. This stimulation of the gagging reflex, or more accurately, the vomiting reflex, is a special problem in prosthodontic service. A hypersensitive gagging reflex often prevents the dentist from carrying out critical procedures or causes them to perform at a less than satisfactory level. In addition, once having suffered an unpleasant gagging experience in a dentist's office, the patients develop a fear of further visits to dentists. The purpose of this paper is to describe methods of managing the gagging patient that has a sound rationale based on modified treatment approaches starting from impression making to design of the prosthesis aided by training dentures to help the patient to tolerate prosthesis in mouth before fabrication of definite prosthesis.


Subject(s)
Denture Design , Denture, Partial, Removable , Gagging/prevention & control , Adaptation, Physiological/physiology , Adult , Alginates/chemistry , Anesthesia, Local , Dental Impression Materials/chemistry , Dental Impression Technique/instrumentation , Denture, Complete, Lower , Desensitization, Psychologic , Equipment Design , Female , Gagging/physiology , Humans , Palate, Soft/physiopathology , Patient Care Planning , Surface Properties
6.
N Y State Dent J ; 77(4): 22-7, 2011.
Article in English | MEDLINE | ID: mdl-21894827

ABSTRACT

Gagging is a protective reflex to stop unwanted entry into the mouth and oropharynx. Some people have a reduced or absent reflex, while others have a pronounced one. Pronounced gag reflexes can compromise all aspects of dentistry, from the diagnostic procedures of examination and radiography to any form of active treatment. In some patients with marked gagging reflexes, it can lead to avoidance of treatment. Many techniques have been described that attempt to overcome this problem, and a variety of management strategies is necessary to aid the delivery of dental care. This is a review of the etiology of gagging problems, clinical assessment, and their classification and categorization prior to clinical treatment. It discusses as well methods for managing patients with gag reflexes during dental treatment.


Subject(s)
Gagging , Acupuncture Points , Dentist-Patient Relations , Desensitization, Psychologic , Gagging/drug effects , Gagging/physiology , Gagging/prevention & control , Humans , Palate, Soft/surgery , Relaxation Therapy
7.
Pediatr. catalan ; 70(1): 21-22, ene.-feb. 2010. ilus
Article in Spanish | IBECS | ID: ibc-80438

ABSTRACT

Introducción. Las fístulas traqueoesofágicas (FTE) tipo H son malformaciones poco frecuentes que pueden asociarse a otras anomalías estructurales. Su diagnóstico puede retardarse debido a la inespecificidad de las manifestaciones clínicas. El tratamiento de elección es quirúrgico, a pesar de estar consiguiendo buenos resultados con técnicas de vaporización con laser. Observación clínica. Presentamos el caso de un lactante de un mes de vida con crisis de tos y cianosis coincidiendo con las tomas que se iniciaron en el nacimiento y se intensificaron progresivamente. Ante la sospecha de FTE se realiza un esofagograma dinámico que revela el paso de contraste de vía digestiva a tráquea por una pequeña fístula. Se confirma el diagnóstico de FTE tipo H por traqueobroncoscopia y se vaporiza con laser. Comentarios. Destacamos la importancia de la sospecha clínica en el diagnóstico de las FTE tipo H y su buen pronóstico con tratamiento quirúrgico(AU)


Introduction. Type H tracheoesophageal fistulas (TEF) are rare congenital malformations that may be associated to other structural anomalies. Their diagnosis may be delayed due to the non-specific clinical manifestations. Surgery is the mainstay of therapy, although recent data suggests that laser vaporization is a promising alternative. Clinical observation. We present the case of a one-month-old infant with repeat episodes of cough and cyanosis since birth. Given the high suspicion for a TEF a dynamic esophagogram was performed, which showed flow of contrast from the digestive tract to the trachea through a small fistula. The diagnosis of type H TEF was confirmed by tracheobronchoscopy, and the patient was successfully treated with laser vaporization. Comments. We highlight the importance of clinical suspicion in the diagnosis of type H TEF as well as their good outcome after laser vaporization(AU)


Subject(s)
Humans , Male , Infant , Gagging/physiology , Tracheoesophageal Fistula/diagnosis , Cough/complications , Tracheoesophageal Fistula/surgery , Bronchoscopy , Laser Therapy , Radiography, Thoracic , Tracheoesophageal Fistula/physiopathology , Tracheoesophageal Fistula , Cough/etiology , Cyanosis/complications , Cyanosis/diagnosis , Esophagus/pathology , Esophagus , Homeopathic Clinical-Dynamic Prognosis , Laser Therapy/trends , Signs and Symptoms
8.
J Am Dent Assoc ; 139(10): 1365-72, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18832272

ABSTRACT

BACKGROUND: The gag reflex regularly interferes with dental procedures. The authors hypothesize that applying pressure to a specific point on the palm alters the gag reflex and that hypersensitive gag reflexes may be categorized according to oropharyngeal landmarks. METHODS: Thirty-six neurologically intact subjects underwent a series of gag reflex trials (baseline, sham and treatment). The authors developed a hand pressure device for subjects to wear, which provided a consistent force, and they described a gag trigger point index (GTPI) scale. On the basis of the GTPI, they divided subjects into a hypersensitive group and an expected-sensitivity (control) group. RESULTS: The trigger point of the gag reflex moved posteriorly in all subjects as a result of pressure to the palm point. Statistical results from repeated measures analysis of variance support the GTPI baseline data, and group assignments helped predict mean GTPI scores across conditions. The authors noted a significant treatment-group interaction effect, which indicated that the difference in mean GTPI responses between the hypersensitive and expected-sensitivity groups depended on the treatment being used. CONCLUSIONS: The authors introduce a treatment involving the stimulation of a pressure point that consistently altered the gag reflex trigger. The results of the study show the need for a more detailed, systematic approach to studying the hypersensitive gag reflex. CLINICAL IMPLICATIONS: The change in trigger point in the hypersensitive group represented a functional gain. Application of the pressure point during dental procedures would decrease the likelihood of triggering a gag reflex.


Subject(s)
Acupressure/methods , Gagging/prevention & control , Acupressure/instrumentation , Adolescent , Cheek/physiology , Equipment Design , Female , Gagging/physiology , Hand , Humans , Male , Oropharynx/physiology , Palatine Tonsil/physiology , Pharynx/physiology , Reflex, Abnormal , Sex Factors , Tongue/physiology , Young Adult
9.
Int J Orofacial Myology ; 33: 48-56, 2007 Nov.
Article in English | MEDLINE | ID: mdl-18942481

ABSTRACT

Twenty-two fundamental methods of jaw, lip, and tongue facilitation were derived from a set of 84 textbooks, clinical guidebooks, and conference proceedings. 95.24% of publications reviewed contained one or more of these twenty-two methods. A description of each technique with examples is provided.


Subject(s)
Lip/physiology , Mandible/physiology , Myofunctional Therapy/methods , Tongue/physiology , Awareness/physiology , Cues , Discrimination, Psychological/physiology , Gagging/physiology , Humans , Muscle Tonus/physiology , Phonetics , Reflex/physiology , Sensation/physiology , Speech/physiology , Speech-Language Pathology , Touch Perception/physiology
10.
SADJ ; 61(6): 258-62, 266, 2006 Jul.
Article in English | MEDLINE | ID: mdl-16977956

ABSTRACT

A pronounced gag reflex can be a severe limitation to a patient's ability to accept dental care and for a clinician's ability to provide it. It can compromise all aspects of dentistry from diagnostic procedures to active treatment and can be distressing for all concerned. Many 'management' techniques have been described. This paper describes the different categories of treatment used to manage people with pronounced gag reflexes.


Subject(s)
Dental Care , Gagging/prevention & control , Acupuncture Therapy , Anesthetics, Local/administration & dosage , Attention , Behavior Therapy , Combined Modality Therapy , Communication , Conscious Sedation , Dentist-Patient Relations , Desensitization, Psychologic , Disease Susceptibility , Electric Stimulation Therapy , Gagging/physiology , Humans , Hypnosis, Dental , Physical Examination , Relaxation Therapy
11.
Dent Update ; 32(2): 74-6, 78-80, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15819150

ABSTRACT

A pronounced gag reflex can be a severe limitation to a patient's ability to accept dental care and for a clinician's ability to provide it. It can compromise all aspects of dentistry from diagnostic procedures to active treatment and can be distressing for all concerned. Many 'management' techniques have been described. This paper describes the different categories of treatment used to manage people with pronounced gag reflexes.


Subject(s)
Dental Care/methods , Gagging , Acupuncture Therapy , Anesthetics, Local/therapeutic use , Behavior Therapy , Conscious Sedation , Gagging/physiology , Gagging/prevention & control , Humans , Hypnosis , Medical History Taking , Transcutaneous Electric Nerve Stimulation
12.
Int J Clin Exp Hypn ; 53(1): 60-73, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15788244

ABSTRACT

The present case report describes a newly developed dental treatment concept for patients with a distinctive gag reflex. "Hypnopuncture" is a combination therapy of hypnosis and acupuncture. Its simple, fast, and effective application autonomous of the cause makes it a valuable tool for dental-emergency treatment procedures. Physiologic and psychological aspects of gagging are influenced at the same time. The protocol is illustrated in the case of a 76-year-old patient with a severe gag reflex who was successfully treated by this combination approach. Necessary and effective therapeutic measures from both acupuncture and hypnosis are portrayed.


Subject(s)
Acupuncture Therapy/methods , Dental Implantation, Endosseous, Endodontic/methods , Emergency Medical Services , Gagging/physiology , Hypnosis , Molar , Reflex, Abnormal/physiology , Aged , Humans , Male
13.
Gen Dent ; 48(4): 446-52, 2000.
Article in English | MEDLINE | ID: mdl-11199620

ABSTRACT

Noninvasive methods advocated by some clinicians are not very successful in dealing with patient gagging, while sedation approaches run the risk of the patient aspirating foreign bodies. The P-6 Neikuan acupuncture point, located on the wrist, has been used in the Far East for thousands of years for its anti-nausea and anti-anxiety properties. In the West, it is the acupuncture point most studied. Only recently has interest been shown in the P-6 point for its possible anti-gagging effect. The anti-gagging effect of P-6 stimulation is documented in this article. The P-6 point has remarkable anti-gagging effects if stimulation is applied correctly. Clinicians may apply thumb pressure at the P-6 point to achieve some effect, although this is not as effective as acupuncture. Nevertheless, a substantial percentage of gagging patients would be able to go through dental procedures without gagging when the P-6 point is stimulated.


Subject(s)
Acupressure , Acupuncture Therapy , Dental Care , Gagging/prevention & control , Acupuncture Points , Adolescent , Adult , Aged , Anesthesia, Dental , Chi-Square Distribution , Conscious Sedation , Double-Blind Method , Gagging/physiology , Humans , Middle Aged , Patient Satisfaction , Placebos , Statistics as Topic , Treatment Outcome , Wrist
14.
Eur J Gastroenterol Hepatol ; 11(2): 201-4, 1999 Feb.
Article in English | MEDLINE | ID: mdl-10102233

ABSTRACT

OBJECTIVE: Unsedated gastroscopy is unpleasant for some patients. The identification of factors related to tolerance would permit the selection of patients for sedation. The aim of the present study was to identify these factors. METHODS: Five hundred and nine patients underwent diagnostic gastroscopy after the administration of topical pharyngeal anaesthesia, without sedation. Patients were grouped as to whether they had undergone prior examinations or not. Tolerance was assessed with a visual analogue scale and a questionnaire. RESULTS: Two hundred and seventy-three (54%) patients underwent gastroscopy for the first time, and 236 (46%) patients had prior experience. Patient tolerance was poor in 84 of 273 (31%) patients undergoing gastroscopy for the first time, and in 61 of 236 (26%) patients with prior experience. Logistic regression analysis identified the following variables related to poor tolerance: (a) in patients undergoing gastroscopy for the first time: presence of gag reflex (odds ratio (OR) = 3.42, 95% confidence interval (CI) 1.90-6.17), apprehension (OR = 2.57, CI 1.33-4.95), young age (OR = 0.95, CI 0.93-0.98) and high level of anxiety (OR = 1.91, CI 0.96-3.89); (b) in patients with prior experience: apprehension (OR = 4.21, CI 1.93-9.20), poor tolerance of prior examinations (OR = 4.92, CI 1.93-12.5) and female (OR = 2.23, CI 1.09-4.57). CONCLUSIONS: The above-mentioned factors are predictive of poor tolerance, and may enable the identification of those patients who might benefit more from sedation for gastroscopy.


Subject(s)
Attitude to Health , Gastroscopy/psychology , Adolescent , Adult , Age Factors , Aged , Anesthesia, Local , Anesthetics, Local/administration & dosage , Anxiety/psychology , Confidence Intervals , Conscious Sedation , Fear/psychology , Female , Forecasting , Gagging/physiology , Gastroscopy/adverse effects , Humans , Logistic Models , Male , Middle Aged , Odds Ratio , Pain Measurement , Patient Selection , Pharynx/drug effects , Sex Factors , Surveys and Questionnaires
16.
Br Dent J ; 182(3): 109-11, 1997 Feb 08.
Article in English | MEDLINE | ID: mdl-9055478

ABSTRACT

There are good reasons for supposing that the problem of 'gagging' for some patients is analogous to a panic attack and is best understood from a cognitive perspective. In my experience, teaching patients to acquire a relaxed abdominal breathing pattern can provide a useful coping strategy for some individuals with a 'gagging' problem.


Subject(s)
Dental Care/psychology , Gagging/physiology , Hyperventilation/prevention & control , Panic Disorder/complications , Breathing Exercises , Cognitive Behavioral Therapy , Humans , Hyperventilation/etiology
17.
J Dev Behav Pediatr ; 17(5): 335-41, 1996 Oct.
Article in English | MEDLINE | ID: mdl-8897222

ABSTRACT

The purpose of this article is to describe hypnobehavioral treatment of five school-age children with maladaptive eating behaviors, including functional dysphagia, food aversion, globus hystericus, and conditioned fear of eating (phagophobia). The unique treatment approach described emphasizes the successful use of self-management techniques, particularly hypnosis, by all five children. Common etiological factors, treatment strategies, and proposed mechanisms of change are discussed. To the authors' knowledge, this is the first such case series in the mainstream pediatric literature describing the use of a hypnobehavioral approach for children with these maladaptive eating problems.


Subject(s)
Behavior Therapy/methods , Feeding and Eating Disorders/therapy , Hypnosis/methods , Adolescent , Autosuggestion , Child , Feeding and Eating Disorders/etiology , Female , Gagging/physiology , Humans , Imagery, Psychotherapy , Male , Phobic Disorders/therapy , Vomiting, Anticipatory/therapy
18.
Aliment Pharmacol Ther ; 6(6): 739-44, 1992 Dec.
Article in English | MEDLINE | ID: mdl-1486159

ABSTRACT

The aim of this study was to determine whether patients' tolerance of upper gastrointestinal endoscopy is related to the dose of lignocaine spray used for oropharyngeal anaesthesia and to measure plasma concentrations at these doses. Sixty consecutive patients undergoing routine upper gastrointestinal endoscopy with sedation were randomized to receive lignocaine spray 50 mg (Group A), 100 mg (Group B) or 200 mg (Group C). Patient, endoscopist and endoscopy nurse were unaware of the variation in dose used. Each patient's tolerance of the intubation and of the remainder of the gastroscopy was assessed independently by the patient, endoscopy nurse, and endoscopist using a visual analogue scale. Plasma lignocaine concentration was measured at 20, 40, 60 and 80 min after administration of the spray. Fifty (83%) patients were unable to recall either the intubation, or the procedure. On the endoscopy nurse's assessment, the patients in Group B tolerated the intubation better than those in Group A, and Groups B and C tolerated the remainder of the gastroscopy better than those in Group A. On the endoscopist's assessment, Groups B and C tolerated the remainder of the gastroscopy better than Group A. There were fewer gags per min in Groups B and C compared to Group A. Mean plasma lignocaine concentrations showed a dose-dependent absorption of the spray, but none exceeded the potentially toxic level of 5 mg/L.


Subject(s)
Anesthesia, Local , Endoscopy, Gastrointestinal/methods , Esophagus/drug effects , Gastroscopy/methods , Lidocaine , Administration, Oral , Administration, Topical , Adolescent , Adult , Aged , Aged, 80 and over , Dose-Response Relationship, Drug , Double-Blind Method , Esophagus/physiology , Female , Gagging/physiology , Humans , Lidocaine/administration & dosage , Lidocaine/blood , Lidocaine/pharmacokinetics , Male , Middle Aged
19.
Anesthesiology ; 75(6): 980-4, 1991 Dec.
Article in English | MEDLINE | ID: mdl-1741519

ABSTRACT

The ability to swallow may be affected by administration of a small dose of muscle relaxant. To test the hypothesis that a subparalyzing dose of a muscle relaxant can impair swallowing, effects of partial paralysis produced by pancuronium on the swallowing reflex were investigated in eight conscious subjects. The swallowing reflex was induced by a bolus injection or a continuous infusion of distilled water into the mesopharynx. The swallowing function was assessed by electromyogram of suprahyoid muscles (EMGSH), mesopharyngeal pressure (Pmeso), and hypopharyngeal pressure (Phypo). Peripheral muscle activity was simultaneously determined by train of four ratio (TOFR) of hypothenar muscles to electrical stimulation of ulnar nerve and by hand grip strength (HGS). Following control measurements, measurements during partial paralysis and after recovery from partial paralysis were performed after intravenous administration of pancuronium 0.02 mg/kg. Partial paralysis significantly depressed EMGSH (bolus injection 44.1 +/- 10.0%, continuous infusion 55.9 +/- 10.2% of control value, P less than 0.01). Pmeso also significantly decreased (bolus injection 64.9 +/- 6.7 to 47.8 +/- 5.8 mmHg, P less than 0.01; continuous infusion 63.4 +/- 7.7 to 52.5 +/- 5.8 mmHg, P less than 0.05). The TOFR of peripheral muscles decreased to 81.4 +/- 6.7% of control value (P less than 0.01), and HGS was reduced from 44.6 +/- 1.9 to 39.4 +/- 2.0 kg (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Deglutition/physiology , Pancuronium/pharmacology , Reflex/drug effects , Adult , Electromyography , Gagging/physiology , Humans , Male
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