ABSTRACT
Low level laser therapy (LLLT) uses light energy, in the form of adenosine triphosphate (ATP), to elicit biological responses in the body. The increased cellular energy and changes in the cell membrane permeability result in pain relief, wound healing, muscle relaxation, immune system modulation, and nerve regeneration. This article investigates the clinical effects of LLLT and explains how it can be applied in the dental field.
Subject(s)
Dental Care , Low-Level Light Therapy , Adenosine Triphosphate/radiation effects , Arthritis/radiotherapy , Cell Membrane Permeability/radiation effects , Dental Implants , Dental Restoration, Permanent , Dentin Sensitivity/radiotherapy , Facial Pain/radiotherapy , Humans , Immunity/radiation effects , Low-Level Light Therapy/methods , Muscle Relaxation/radiation effects , Muscle, Skeletal/radiation effects , Nerve Regeneration/radiation effects , Orthodontics, Corrective , Osteoarthritis/radiotherapy , Pain/radiotherapy , Pain, Postoperative/prevention & control , Periodontal Diseases/radiotherapy , Safety , Temporomandibular Joint Disorders/radiotherapy , Tooth Diseases/radiotherapy , Tooth Extraction , Wound Healing/radiation effectsABSTRACT
BACKGROUND AND OBJECTIVE: It is unknown if the decreased ability to relax airway smooth muscles in asthma and other inflammatory airways disorders can be influenced by low level laser therapy (LLLT) irradiation. To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats. STUDY DESIGN/MATERIALS AND METHODS: Controlled rat study where trachea was dissected and mounted in an organ bath apparatus with or without a TNF-alpha solution. RESULTS: Low level laser therapy administered perpendicularly to a point in the middle of the dissected trachea with a wavelength of 655 nm and a dose of 2.6 J/cm(2), partially restored TSM relaxation response to isoproterenol. Tension reduction was 47.0 % (+/-2.85) in the laser-irradiated group compared to 22.0% (+/-2.21) in the control group (P < 0.01). Accumulation of cAMP was almost normalized after LLLT at 22.3 pmol/mg (+/-2.1) compared to 17.6 pmol/mg (+/-2.1) in the non-irradiated control group (P < 0.01). CONCLUSION: Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol.