ABSTRACT
Nevus depigmentosus (ND), also known as nevus achromicus or achromic nevus, is an uncommon congenital hypomelanosis of the skin that is often characterized as being nonprogressive and having serrated borders. It needs to be distinguished from other hypopigmented skin conditions such as nevus anemicus, hypomelanosis of Ito, Fitzpatrick patches (ash leaf spots) of tuberous sclerosis, vitiligo, indeterminate leprosy, and pigment demarcation lines. Treatment may be desired for aesthetic and possible psychosocial considerations. We review and update knowledge about ND and its simulants.
Subject(s)
Hypopigmentation/diagnosis , Nevus/diagnosis , Diagnosis, Differential , Esthetics , Humans , Hypopigmentation/epidemiology , Hypopigmentation/psychology , Hypopigmentation/therapy , Leprosy/diagnosis , Low-Level Light Therapy , Melanocytes/pathology , Melanocytes/transplantation , Nevus/epidemiology , Nevus/psychology , Nevus/therapy , PUVA Therapy , Risk Factors , Tuberous Sclerosis/diagnosisABSTRACT
A previously healthy 86-year-old male was transported by ambulance to the trauma bay of the emergency department (ED) for profuse bleeding from the left temple. The ambulance crew raised concern that the volume and force of the bleed may suggest arterial involvement. The patient reported having applied a natural topical remedy to a mole two weeks prior at the recommendation of a naturopath. The patient described progressive blackening and swelling of the area in the days following the single application of the product. After gaining control of the bleeding in the ED, the area was found to have a raised, 2 cm eschar.
Subject(s)
Antineoplastic Agents, Phytogenic/adverse effects , Benzophenanthridines/adverse effects , Burns, Chemical/etiology , Chlorides/adverse effects , Facial Neoplasms/drug therapy , Hemorrhage/chemically induced , Isoquinolines/adverse effects , Nevus/drug therapy , Skin Neoplasms/drug therapy , Zinc Compounds/adverse effects , Administration, Cutaneous , Aged, 80 and over , Antineoplastic Agents, Phytogenic/administration & dosage , Benzophenanthridines/administration & dosage , Burns, Chemical/diagnosis , Burns, Chemical/therapy , Chlorides/administration & dosage , Facial Neoplasms/diagnosis , Hemorrhage/therapy , Humans , Isoquinolines/administration & dosage , Male , Nevus/diagnosis , Self Medication/adverse effects , Skin Neoplasms/diagnosis , Treatment Outcome , Zinc Compounds/administration & dosageABSTRACT
The association of hypophosphataemic rickets with verrucous epidermal naevus (EN) and elevated fibroblast growth factor 23 levels is known as cutaneous-skeletal hypophosphataemia syndrome (CSHS), and can be caused by somatic activating mutations in RAS genes. We report a unique patient with CSHS associated with giant congenital melanocytic naevus (CMN), neurocutaneous melanosis and EN syndrome, manifesting as facial linear sebaceous naevus, developmental delay and ocular dermoids. An activating mutation Q61R in the NRAS gene was found in affected skin and ocular tissue but not blood, implying that the disparate manifestations are due to a multilineage activating mutation (mosaic RASopathy). We speculate on the apparently rare association of CSHS with CMN compared with EN. We also report the favourable outcome of this patient at the age of 8 years after extensive neonatal curettage of the giant CMN and use of vitamin D and phosphate supplementation.
Subject(s)
DNA, Neoplasm/genetics , GTP Phosphohydrolases/genetics , Membrane Proteins/genetics , Mosaicism , Nevus, Pigmented/genetics , Nevus/genetics , Rickets, Hypophosphatemic/genetics , Skin Neoplasms/genetics , Skin/pathology , Child, Preschool , DNA Mutational Analysis , GTP Phosphohydrolases/metabolism , Humans , Male , Membrane Proteins/metabolism , Mutation , Nevus/diagnosis , Nevus/metabolism , Nevus, Pigmented/diagnosis , Nevus, Pigmented/metabolism , Rickets, Hypophosphatemic/congenital , Rickets, Hypophosphatemic/diagnosis , Skin Neoplasms/diagnosis , Skin Neoplasms/metabolismABSTRACT
Los nervios epidérmicos verrugosos son lesiones hamartomatosas que se diferencian esencialmente hacia queratinocitos epidérmicos. Ciertas características clínicas e histopatológicas han permitido la individualización del llamado nevo epidérmico verrugoso inflamatorio lineal (NEVIL). Un varón de 42 años presentaba en la extremidad inferior derecha una dermatosis eritematosa y queratósica que se extendía longitudinalmente siguiendo el trayecto de las líneas de Blaschko. En el seno de la previa dermatosis desarrolló en los últimos años varias lesiones tumorales exofíticas cuyo estudio histológico reveló únicamente una intensa papilomatosis de naturaleza benigna. Describimos el ejemplo de un nevo epidérmico verrugoso inflamatorio lineal que en la edad adulta desarrolló múltiples proliferaciones vegetantes de carácter puramente hiperplásico (AU)
Subject(s)
Adult , Male , Humans , Hyperplasia/diagnosis , Nevus/diagnosis , Skin Neoplasms/diagnosis , Clinical Evolution , Foot Dermatoses/diagnosis , Foot Dermatoses/complications , Papilloma/diagnosisABSTRACT
El leucoedema es una patología oral supuestamente muy frecuente, mientras que el nevo blanco esponjoso es una rareza. Sin embargo, ambas entidades son muy parecidas en cuanto a clínica, histopatología, microscopia electrónica, evolución y tratamiento. Se presenta el caso de un varón de 46 años con lesiones blanquecinas en la mucosa oral. Se realiza un exhaustivo diagnóstico diferencial entre leucoedema y nevo blanco esponjoso, llegándose a la conclusión de que son entidades relacionadas (AU)
Subject(s)
Male , Middle Aged , Humans , Leukoedema, Oral/diagnosis , Nevus/diagnosis , Skin Neoplasms/diagnosis , Leukoedema, Oral/complications , Leukoedema, Oral/etiology , Leukoedema, Oral/drug therapy , Clinical Evolution , Diagnosis, Differential , Tobacco Use Disorder/adverse effects , Mouth Mucosa/parasitology , Mouth Mucosa/pathology , Nevus/complications , Nevus/etiology , Nevus/drug therapy , Candida/isolation & purification , Candida/pathogenicity , Tongue/parasitology , Tongue/pathology , Fluconazole/pharmacology , Amoxicillin/pharmacologyABSTRACT
São apresentados dois pacientes com nevos organóides complexos, tratados laser de CO2, com bom resultado estético e curativo (AU)
Subject(s)
Adult , Male , Humans , Nevus/surgery , Lasers/therapeutic use , Skin Neoplasms/surgery , Nevus/diagnosis , Clinical Diagnosis , Forehead/radiation effects , Forehead/pathology , Buttocks/radiation effects , Laser Therapy/methods , Laser Therapy/instrumentationABSTRACT
El nevo de Becker es un hamartoma cutáneo hiperpigmentado e hipertricósico, de localización usualmente unilateral, de presentación más frecuente en sexo masculino. La mayoría de los casos se manifiestan durante la pubertad, pero se ha publicado actualmente la existencia de casos congénitos. Excepcionalmente presenta una agregación familiar, con una herencia autosómica dominante. Se postula una influencia androgénica en su desarrollo, dada su mayor presentación durante la adolescencia. Este nevo puede asociarse a malformaciones cutáneas, esqueléticas y musculares, describiéndose dos nuevos síndromes recientemente relacionados con la presencia del nevo de Becker. Se presenta un resumen de actualidad en cuanto a su patología y tratamiento