ABSTRACT
Nomifensine efficiency in the improvement of memory trace restoration impaired by spontaneous forgetting or amnesic influence was demonstrated in experiments on BALB/c mice by using the passive avoidance technique. Doses of 10-20 mg/kg proved to be the most efficient. The presented results suggest that the antiamnesic effect of nomifensine is due to the activation of dopaminergic and noradrenergic systems.
Subject(s)
Amnesia/drug therapy , Nomifensine/therapeutic use , Animals , Conditioning, Classical/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Electric Stimulation , Escape Reaction/drug effects , Male , Mice , Mice, Inbred BALB C , Reaction Time/drug effects , Time FactorsABSTRACT
Nomifensine has demonstrated efficacy in several animal models that have been found to be predictive of clinical antidepressant activity, and has also been found to have a low potential for both cardiovascular and anticholinergic side effects. A comparison of nomifensine's profile with those of standard antidepressant agents shows this drug to possess clear advantages which may make it an attractive choice for the treatment of endogenous depression.