Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health - a comprehensive review.

Nutraceuticals have gained immense importance in poultry science recently considering the nutritional and beneficial health effects of their constituents. Besides providing nutritional requirements to birds, nutraceuticals have beneficial pharmacological effects, for example, they help in establishing normal physiological health status, prevent diseases and thereby improve production performance. Nutraceuticals include amino acids, vitamins, minerals, enzymes, etc. which are important for preventing oxidative stress, regulating the immune response and maintaining normal physiological, biochemical and homeostatic mechanisms. Nutraceuticals help in supplying nutrients in balanced amounts for supporting the optimal growth performance in modern poultry flocks, and as a dietary supplement can reduce the use of antibiotics. The application of antibiotic growth enhancers in poultry leads to the propagation of antibiotic-resistant microbes and drug residues; therefore, they have been restricted in many countries. Thus, there is a demand for natural feed additives that lead to the same growth enhancement without affecting the health. Nutraceuticals substances have an essential role in the development of the animals' normal physiological functions and in protecting them against infectious diseases. In this review, the uses of amino acids, vitamins and minerals as well as their mode of action in growth promotion and elevation of immune system are discussed.

An IoT Platform Towards the Enhancement of Poultry Production Chains.

As a consequence of the projected world population growth, world meat consumption is expected to grow. Therefore, meat production needs to be improved, although it cannot be done at any cost. Maintaining the health and welfare status of animals at optimal levels has traditionally been a main concern of farmers and, more recently, consumers. In this article, the Poultry Chain Management (PCM) platform is presented. It aims at collecting data across the different phases of the poultry production chain. The collection of these data not only contributes to determining the quality of each phase and the poultry production chain as a whole, but more importantly, to identifying critical issues causing process inefficiencies and to support decision-making towards the holistic improvement of the production chain. Results show that the information gathered can be exploited to make different suggestions to guarantee poultry welfare and, ultimately, improve the quality of the meat.

Phytoecdisteroids from Serratula coronata when growing ducklings.

This article presents the results of comprehensive studies to analyze the effect of a mixture of phytoecdysteroids extracted from the juice of Serratula coronata L. on the productivity and vitality of ducklings when grown for meat, and the optimal doses of its inclusion in the diet of the bird are revealed. The methodological basis of this study was the earlier works of domestic and foreign scientists on the topic under study. In the studies, a mixture of ecdysteroids extracted from the juice of the Serratula coronata L. was used according to the method developed by a team of scientists of the Ufa Federal Research Center of the Russian Academy of Sciences (Patent RU 2151598). The object of the study was the young ducks of the cross breed "Agidel 34" of the Beijing breed. It was established that the use of phytoecdysteroids in the diets of ducklings at a dose of 1.0 mg/l of drinking water allowed to increase the safety of the livestock by 4.0%, live weight by 4.5% (p <  0.01), average daily live weight gain by 3.0-3.5%, gutted carcass weight - 7.1%. At the same time, feed costs per unit of production decreased by 2.0%, and the profitability of duck meat production increased by 5.2%.

Floor space and betaine supplementation alter the nutrient digestibility and performance of Japanese quail in a tropical environment.

This study investigated the effects of floor space and betaine supplementation on the nutrient digestibility and performance of laying quail, at an advanced stage of production, in a tropical environment. In total, 408 laying quail (23 weeks old) were distributed in 3 × 2 factorial arrangements with four replicates. The first factor was floor space (250 cm2 [FS-1], 221 cm2 [FS-2], and 200 cm2 per bird [FS-3]) by allocating 15, 17, and 19 birds per cage (cage size: 3750 cm2). The second factor was betaine supplementation, administered at levels of 0 (Control) and 0.12% (Betaine). The birds were housed under a natural, tropical environment that was outside the predominant thermoneutral zone, indicating heat stress conditions. Interactions were found between floor space and betaine on crude fiber digestibility, egg production, and eggshell thickness, with the highest values being yielded in FS-2 group supplemented with betaine. Reducing the floor space to 200 cm2 negatively affected nutrient digestibility and performance. The birds kept in FS-3 had lower (P < 0.05) dry matter, crude protein, crude fat, and calcium digestibility values than those kept in FS-1 and FS-2. Birds housed in FS-2 exhibited higher egg weight than those in FS-3 (P < 0.05), although they did not differ from those in FS-1. Furthermore, a lower eggshell weight in FS-3, compared with FS-1 and FS-2, was observed (P < 0.01). Betaine supplementation enhanced the dry matter, crude protein, crude fat, crude ash, and calcium digestibility values (P < 0.05). Accordingly, betaine improved feed intake, egg weight, feed conversion, and protein and energy efficiency ratios (P < 0.01). Betaine also resulted in higher albumen, yolk, and eggshell weights (P < 0.01). In conclusion, a floor space of 221 cm2, combined with betaine supplementation at 0.12%, can be applied for raising quail under high environmental temperatures.

Role of Mushroom as Dietary Supplement on Performance of Poultry.

The objective of this review is to summarize the effect of commonly used mushrooms (particularly Pleurotus ostreatus or oyster mushroom, Agaricus bisporus or Button mushroom, Lentimula edodes or shiitake mushroom, and Ganoderma lucidum or reishi mushroom) in poultry diets on performance of broilers and layers. It can be concluded from different studies that mushrooms and their polysaccharides can play important roles in poultry production: (1) Polysaccharides in mushrooms may act as immune enhancers or immunomodulators and show antibacterial, antiviral, antiparasitic bioactivities; (2) phenolic compounds of mushrooms may act as antioxidants; (3) mushrooms in broiler's diet may be used as growth promoters as an alternative to antibiotics; (4) mushrooms in the diet may improve egg production and quality; (5) mushrooms may be used as a safe and effective alternative for inducing molt, enhancing immunity, reducing Salmonella growth, and returning to egg production. Further studies are needed to investigate the effects of mushrooms to improve productive performance in chickens and to illuminate the possible modes of action related to the gut ecosystem and the immune response.

Basic mechanisms of the regulation of L-carnitine status in monogastrics and efficacy of L-carnitine as a feed additive in pigs and poultry.

A great number of studies have investigated the potential of L-carnitine as feed additive to improve performance of different monogastric and ruminant livestock species, with, however, discrepant outcomes. In order to understand the reasons for these discrepant outcomes, it is important to consider the determinants of L-carnitine status and how L-carnitine status is regulated in the animal's body. While it is a long-known fact that L-carnitine is endogenously biosynthesized in certain tissues, it was only recently recognized that critical determinants of L-carnitine status, such as intestinal L-carnitine absorption, tissue L-carnitine uptake, endogenous L-carnitine synthesis and renal L-carnitine reabsorption, are regulated by specific nutrient sensing nuclear receptors. This review aims to give a more in-depth understanding of the basic mechanisms of the regulation of L-carnitine status in monogastrics taking into account the most recent evidence on nutrient sensing nuclear receptors and evaluates the efficacy of L-carnitine as feed additive in monogastric livestock by providing an up-to-date overview about studies with L-carnitine supplementation in pigs and poultry.

The evolution and application of enzymes in the animal feed industry: the role of data interpretation.

1. Enzymes have been used commercially for nearly 40 years and save significant costs through sparing of expensive nutrients but the mechanism by which this is achieved is still debated. 2. The research focused on non-starch polysaccharidase (NSPase) enzymes is used as an example of where greater progress could have been made if the details of the work had been described more fully and the analysis of the data generated had been broader in scope and more critical. 3. Lack of standardisation of the details presented in the materials and methods has been identified as a significant barrier to meaningful retrospective analysis and thus limits advances in the understanding of the mode of action of these enzymes. 4. The identity of the enzyme employed and its activity is often lacking, and more importantly the purity is rarely disclosed. Contaminant activities which are neither listed nor assayed could play a significant role in the responses observed. 5. The dose optimum of most enzymes is often considerably higher than that employed in most studies. Thus studies claiming synergy between two 'activities' should ensure that the response is not related to each enzyme simply augmenting the dose of just one activity in the finished feed. This is a common problem, and coupled with the lack of factorial experiments to justify the presence of each enzyme in a multi-enzyme product, it is not surprising that there is still debate as to whether single or multi-enzymes are best suited poultry rations. 6. The three proposed mechanisms for NSPases (viscosity, cell wall and prebiotic) are discussed, and along with their strengths and weaknesses it is suggested that a re-evaluation of each is needed. Viscosity may have to be re-evaluated as being a function not only of the cereal being fed, but of the age of the animal as well. The cell wall theory as described is poorly modelled in vitro and hence the validity of these data is questioned. The prebiotic theory may need significant modification as it appears that the quantities of oligomers produced are insufficient to generate the additional volatile fatty acids (VFA)'s reported. It is likely that all three mechanisms play a role in the responses observed, but the prebiotic mechanism probably plays by far the most important part in low viscosity diets. 7. Future research would be improved if it considered all potential mechanisms when designing a trial. Significant failings are apparent as a result of adherence to tenets in explanation of the results. Most importantly, it should be emphasised that a hypothesis is there to be tested, not defended.

In ovo applications in poultry: A review,.

The various methods employed for the in ovo administration of different materials for promoting the health and productivity of poultry are discussed in this review article. The amnion has proven to be an effective site for injection and the timing of in ovo injection has commonly occurred at transfer. However, the volumes and dosages or concentrations of the materials administered vary depending on bird type, egg size, timing and site of injection, incubation system and regimen, and the type of material. Both manual and automated injections have been shown to be effective. Nevertheless, commercial application mandates automation. Materials described in the literature over the past 20 years or more for in ovo use in avian species include vaccines, drugs, hormones, competitive exclusion cultures and prebiotics, and supplemental nutrients. Vaccines approved for in ovo delivery include those for Marek's disease, infectious bursal disease, fowl pox, Newcastle disease, and coccidiosis. Some of the materials listed above have been shown to be viable candidates for enhancing immunity and for promoting embryonic and posthatch development. Several reports have indicated that probiotics may be effectively used to fight intestinal bacterial infections, and folic aid, as well as egg white protein and various amino acids, including L-arginine, L-lysine, L-histidine, HMB, and threonine alone or in combination, have been shown to benefit embryonic development or posthatch performance. Furthermore, CpG oligodeoxynucleotides, vitamins C and E, and thyme and savory have the potential to enhance immunity, carbohydrates can be used to increase tissue glycogen stores, and creatine can be used to promote muscle growth. Trace minerals and vitamin D3 have shown potential to improve bone strength, and potassium chloride may be an effective alternative electrolyte in vaccine diluent. The in ovo application of these and other materials will continue to expand and provide further benefits to the poultry industry.

Reduction of nitrogen excretion and emission in poultry: A review for organic poultry.

Organic poultry is an alternative to conventional poultry which is rapidly developing as a response to customers' demand for better food and a cleaner environment. Although organic poultry manure can partially be utilized by organic horticultural producers, litter accumulation as well as excessive nitrogen still remains a challenge to maintain environment pureness, animal, and human health. Compared to conventional poultry, diet formulation without nitrogen overloading in organic poultry is even more complicated due to specific standards and regulations which limit the application of some supplements and imposes specific criteria to the ingredients in use. This is especially valid for methionine provision which supplementation as a crystalline form is only temporarily allowed. This review is focused on the utilization of various protein sources in the preparation of a diet composed of 100% organic ingredients which meet the avian physiology need for methionine, while avoiding protein overload. The potential to use unconventional protein sources such as invertebrates and microbial proteins to achieve optimal amino acid provision is also discussed.

The Role of Direct-Fed Microbials in Conventional Livestock Production.

Supplementation of direct-fed microbials (DFM) as a means to improve the health and performance of livestock has generated significant interest over the past 15+ years. A driving force for this increased interest in DFM is to reduce or eliminate the use of low-dose antibiotics in livestock production. This increased attention toward DFM supplementation has generated an extensive body of research. This effort has resulted in conflicting reports. Although there has been considerable variation in the design of these studies, one of the main causes for this lack of consistency may be attributed to the variation in the experimental immune challenge incorporated to evaluate DFM supplementation. Taking into account the experimental immune challenge, there is strong evidence to suggest that DFM supplementation may have an impact on the immune response, overall health, and performance of livestock.

Effects of dietary vitamin E on fertility functions in poultry species.

Vitamin E is found in high quantities in vegetable oils. Although vitamin E has multiple functions in humans and animals, its key function is protecting cells from oxidative damage. Since its discovery, several studies have demonstrated that vitamin E deficiency causes impaired fertility in humans and lab animals. However, the effects of vitamin E deficiency or of its supplementation on the fertility of farm animals, particularly on poultry, are less well studied. Therefore, a comprehensive review of the effects of dietary vitamin E on the fertility of poultry species is needed in order to understand the beneficial role of vitamin E in the maintenance of sperm and egg qualities. Based on the observations reviewed here, we found that a moderate amount of vitamin E in poultry diet significantly protects semen/sperm qualities in male birds and egg qualities in female birds via decreasing the lipid peroxidation in semen/sperms and eggs. This review provides an overall understanding of the effects of dietary vitamin E on fertility functions in poultry species.

The use of green tea (Camellia sinensis) as a phytogenic substance in poultry diets.

This review examined the use of green tea (Camellia sinensis) in the diets of poultry. Research findings were obtained from various recent studies, where much attention was focused on the role of green tea in the promotion of both animal and human health. The review involved some of the currently available information about green tea, pertaining to its chemical composition, anticoccidial and antimicrobial effect, effect on broiler and layer performance and on blood and egg yolk constituents. To the author's knowledge this is the first review paper on this topic. It will be helpful for poultry nutritionists and the poultry industry, although more detailed studies are still needed to elucidate the effects of green tea in poultry nutrition under various circumstances.

Interpreting experimental data on egg production--applications of dynamic differential equations.

This contribution focuses on applying mathematical models based on systems of ordinary first-order differential equations to synthesize and interpret data from egg production experiments. Models based on linear systems of differential equations are contrasted with those based on nonlinear systems. Regression equations arising from analytical solutions to linear compartmental schemes are considered as candidate functions for describing egg production curves, together with aspects of parameter estimation. Extant candidate functions are reviewed, a role for growth functions such as the Gompertz equation suggested, and a function based on a simple new model outlined. Structurally, the new model comprises a single pool with an inflow and an outflow. Compartmental simulation models based on nonlinear systems of differential equations, and thus requiring numerical solution, are next discussed, and aspects of parameter estimation considered. This type of model is illustrated in relation to development and evaluation of a dynamic model of calcium and phosphorus flows in layers. The model consists of 8 state variables representing calcium and phosphorus pools in the crop, stomachs, plasma, and bone. The flow equations are described by Michaelis-Menten or mass action forms. Experiments that measure Ca and P uptake in layers fed different calcium concentrations during shell-forming days are used to evaluate the model. In addition to providing a useful management tool, such a simulation model also provides a means to evaluate feeding strategies aimed at reducing excretion of potential pollutants in poultry manure to the environment.

Evaluation of near-infrared reflectance spectroscopy (NIRS) techniques for total and phytate phosphorus of common poultry feed ingredients.

The purpose of this study was to determine the feasibility of estimating the total and phytate P content of common poultry feed ingredients by near-infrared reflectance spectroscopy (NIRS). Samples of 8 plant-origin feedstuffs were collected from poultry producers in the USA and Canada during the summer of 2009: corn (133), soybean meal (114), corn distillers dried grains with solubles (DDGS; 89), bakery by-product meal (95), wheat (22), wheat middlings (31), canola meal (21), and wheat shorts (15). The samples were assayed by standard wet chemical techniques for total and phytate P contents. There was considerable variation found in most of the ingredient components. The average values for the laboratory determinations versus NIRS predictions were all within 0.030 for total phosphorus and 0.012 for phytate P. For phytate P, the magnitude of the standard errors of the predictions ranged from 0.009% for soybean meal to 0.012% for canola meal. These values may be sufficiently precise for nutritionists to use the NIRS predictions to estimate how much of the P in their ingredients is not available to the birds. For total P, the magnitude of the standard errors of the predictions ranged from 0.027% for corn DDGS to 0.142% for wheat middlings. In general, total P predictions by NIRS were not generally sufficiently precise for most nutritionists to use in feed formulation. Decision making may be quite easy in using NIRS estimates for the phytate P content of bakery by-product meal [R(2) = 0.89 for predicted = f (determined)] but not for the total P content of soybean meal (R(2) = 0.03). It is concluded that precise estimates of phytate P through NIRS should allow nutritionists for more efficient formulate and mix feed, lowering feed costs and reducing the amount of residual polluting phosphorus in poultry excreta.

Factors that affect the nutritive value of canola meal for poultry.

This article reviews the factors affecting the nutritive value of canola meal (CM), including glucosinolates, sinapine, phytic acid, tannins, dietary fiber, and electrolyte balance. It also addresses the means of improving the nutritive value of CM throughout seed dehulling, development of low-fiber canola, or application of feed enzymes. Over the years, the glucosinolate content of canola has been declining steadily and is now only about one-twelfth of that of the older high-glucosinolate rapeseed (that is, 10 vs. 120 µmol/g). Therefore, the rations for broilers or laying hens could now contain 20% of CM without producing any adverse effects. Tannins are of lesser importance due to their presence in the hull fraction and thus low water solubility. Sinapine has been implicated with the production of a "fishy" taint in brown-shelled eggs, which results from a genetic defect among the strain of Rhode Island Red laying hens. The White Leghorns have been reported not to be affected. Although lower in protein, CM compares favorably with soybean meal with regard to amino acid content. Because CM contains more methionine and cysteine but less lysine, both meals tend to complement each other when used together in poultry diets. Canola meal is low in arginine (Arg) which could be of importance when introducing CM to broiler diets at high inclusion rates. The Arg content of CM is approximately two-thirds of that of soybean meal. Chickens fail to synthesize Arg and are highly dependent on dietary sources for this amino acid. Supplementation of Arg to CM-based diets has been shown to partly restore the growth performance. Dietary cation-anion difference in CM is also less than optimal due to the high sulfur and low potassium contents. Seed dehulling has not been very successful due to excessive fineness and thus difficulties with percolation of the miscella through the cake. Development of low-fiber, yellow-seeded canola and the use of enzymes have proven to increase the energy utilization and the nutritive value of CM for poultry.

Phytate and other nutrient components of feed ingredients for poultry.

Samples of feed ingredients were collected from poultry feed mills in the United States and Canada: corn (133), soybean meal (114), corn distillers dried grains with solubles (DDGS; 89), bakery by-product meal (95), wheat (22), wheat middlings (31), canola meal (21), and wheat shorts (15). The samples were assayed by standard wet chemical techniques for CP, fat, neutral detergent fiber (NDF), acid detergent fiber, calcium, phosphorus, phytate phosphorus, and ash. There was considerable variation found in most of the ingredient components. Forty-two of the 64 CV were above 10.0%. The calcium contents of the ingredients were the most variable, followed by the fat contents. The CP contents were the least variable. There were some fairly consistent relationships observed across samples; in general, acid detergent fiber and NDF were positively correlated, as were ash and mineral levels. Crude protein and fiber levels were positively related, except for wheat shorts, but the relationships were not strong. Phytate P was found to be positively related to ash and total P, as expected, except for corn DDGS. The fat content of corn was found to be negatively related to the NDF content. Significant (P < 0.004) linear regressions were found between phytate P and total P for corn, soybean meal, bakery by-product meal, wheat, wheat middlings, and wheat shorts. The average nonphytate P content of the ingredients was 49.8%, ranging from 38.8% for wheat middlings to 73.2% for DDGS. The phytate P content of wheat and wheat by-products could be predicted from their proximate compositions, with coefficients of determination in excess of 0.740. Predictions for the other ingredients were not as good.

Dietary plant bioactives for poultry health and productivity.

1. Plants and their biologically active chemical constituents, sometimes called secondary metabolites or bioactives, present numerous opportunities for the improvement of livestock production by inclusion in the diet. 2. Many such plant derived materials have well established therapeutic values in man; however, their potential as feed additives in animal production, particularly of poultry, remains largely unexploited. 3. There is increasing evidence indicating that they can be efficient in controlling diseases, and plant bioactives may also influence production parameters such as feed efficiency and product quality. 4. It has been reported that they may even replicate some of the effects of antibiotic growth promoters, which were banned from use in Europe from 2006. 5. This review assesses the status of plant bioactives in poultry production and their mode of action on avian physiology, particularly in the digestive tract.

Review on the role of dietary zinc in poultry nutrition, immunity, and reproduction.

Zinc is an important nutrient in animal metabolism. In poultry, zinc serves not only as a nutrient but can also be used as a dietary supplement to manipulate the reproductive system of the bird. This article summarizes the general biochemistry, physiology, and nutritional aspects of zinc metabolism to provide a brief overview on what is known regarding zinc. The potential role of zinc in poultry immune response, Salmonella infection, and molting are emphasized.

Animal management to reduce phosphorus losses to the environment.

Water quality in the United States is threatened by contamination with nutrients, primarily nitrogen and phosphorus. Animal manure can be a valuable resource for farmers, providing nutrients, improving soil structure, and increasing vegetative cover to decrease erosion potential. At the same time, application of manure nutrients in excess of crop requirements can result in environmental contamination. Environmental concerns with P are primarily associated with pollution of surface water (streams, lakes, rivers). This pollution may be caused by runoff of P when application to land is in excess of crop requirements. Increased specialization and concentration of livestock and crop production has led to the net export of nutrients from major crop-producing areas of the country to areas with a high concentration of animal agriculture. Concentrated animal agriculture has been identified as a significant source of P contamination of surface water. Areas facing the dilemma of an economically important livestock industry concentrated in an environmentally sensitive area have few options. If agricultural practices continue as they have in the past, continued damage to water resources and a loss of fishing and recreational activity are inevitable. If agricultural productivity is decreased, however, the maintenance of a stable farm economy, a viable rural economy, and a reliable domestic food supply are seriously threatened. Decreasing the P content of manure through nutrition is a powerful, cost-effective approach to reducing P losses from livestock farms and will help farmers meet increasingly stringent environmental regulations. This paper reviews opportunities available to reduce the P content of livestock manure, including more accurate interpretation of the published P requirements of animals, improved diet formulation and group-feeding strategies to more precisely meet requirements, and approaches to improve availability of feed P for monogastric and ruminant species.

Conjugated linoleic acid and its effects on animal products and health in single-stomached animals.

Conjugated linoleic acids (CLA) have been shown to have anti-carcinogenic, anti-obesity, anti-atherogenic and immunomodulatory functions. The basis for these effects has not been fully explained, but probably involves effects of CLA on eicosanoid metabolism, cytokine production and/or gene expression. The predominant isomer (85-90%) in the natural sources of CLA has the cis-9, trans-11 configuration. As interest in CLA grew and synthetic forms became available, the number of studies examining the effects of dietary CLA in rodents, human subjects and livestock has increased greatly. In the late 1990s the observation that CLA had anti-obesity effects was reported. Subsequently, it was determined that this effect in mice could be attributed to the trans-10, cis-12 isomer that, along with the cis-9, trans-11 isomer, predominates in the synthetic forms of CLA. The anti-obesity response varies in magnitude depending on species, and has not been consistent in non-rodents. In general, the response is greatest in mice and less or absent in other species. The basis for this lack of consistency is not clear and is unlikely to be accounted for by differences in the source of CLA. In the pig variation in body fat of animals may account for differences in responsiveness. There is no direct evidence of an anti-carcinogenic effect of CLA in human subjects or livestock. Indirect evidence from in vitro studies with cell lines, as well as epidemiological studies, suggest that CLA may be relevant as a natural anti-carcinogen. The immunomodulatory effects of CLA may have application in livestock production as an alternative to the use of feed antibiotics, or as a means of improving the response to vaccination and conferring disease resistance. The recent literature on the effects of CLA, with emphasis on its anti-obesity effects, is reviewed.