ABSTRACT
The term cutaneous pseudolymphoma (C-PSL) is defined in the literature as a benign, reactive lymphoproliferation that clinically and/or histopathologically imitates cutaneous lymphoma. The exact etiopathogenesis has not been fully elucidated to date. A distinction is made between primary, idiopathic PSL without an identifiable cause and secondary PSL with a known stimulus. We report the occurrence of pseudolymphoma after treatment with medicinal leeches (hirudotherapy). To the best of our knowledge, a total of only nine cases of cutaneous PSL after hirudotherapy have been reported in the literature to date.
Subject(s)
Lymphoma, Non-Hodgkin , Pseudolymphoma , Skin Neoplasms , Humans , Pseudolymphoma/chemically induced , Pseudolymphoma/diagnosisSubject(s)
Cimicifuga/adverse effects , Phytotherapy/adverse effects , Plant Extracts/adverse effects , Plant Preparations/adverse effects , Adverse Drug Reaction Reporting Systems , Europe , Female , Humans , Middle Aged , Pseudolymphoma/chemically induced , Skin Diseases/chemically induced , Skin Diseases, Vascular/chemically induced , Vasculitis/chemically inducedABSTRACT
We report a 56-year-old female patient who presented with asymptomatic, localized erythematous plaques on arms and legs. Histologically, the diagnosis of pseudolymphoma (PL) was confirmed. Because of menopausal complaints, the patient had been taking Remifemin(R), a phytotherapeutical agent containing a standardized extract of black cohosh (Cimicifuga racemosa) rhizome for 1 year. Six months after initial administration of this herbal drug, first skin lesions appeared which continuously increased. Withdrawal of Remifemin resulted in regression and complete remission of the lesions within 12 weeks. To the best of our knowledge, this is the first report on cutaneous PL induced by a standardized extract of C. racemosa rhizoma. Thus, though claimed to be poor in adverse effects, the potency of phytotherapeutical agents to induce uncommon cutaneous eruptions needs to be taken into careful reconsideration since the course of cutaneous PL tends to be chronic and indolent if the causative agent is not discontinued.
Subject(s)
Cimicifuga/adverse effects , Plant Extracts/adverse effects , Pseudolymphoma/chemically induced , Skin Diseases/chemically induced , Biopsy , Diagnosis, Differential , Female , Humans , Middle Aged , Pseudolymphoma/pathology , Skin Diseases/pathologyABSTRACT
Cases of pseudolymphoma induced by intradermal gold injection or gold piercing have previously been described. Most of these cases showed the histopathological finding of B-lymphocyte predominant lymphocytoma cutis. We describe a patient with gold acupuncture-induced T-cell-rich pseudolymphoma. Some T cells showed positive staining with CD30. The lesions responded to an intralesional injection of triamcinolone acetonide.