ABSTRACT
PURPOSE: Because patients often take iron supplements without medical indication, and iron can accumulate in vascular endothelial cells, the authors evaluated the association of oral iron supplementation with retinal/subretinal hemorrhage in patients with neovascular age-related macular degeneration. METHODS: A post hoc secondary data analysis of comparison of age-related macular degeneration treatments trials was performed. Participants were interviewed for use of oral iron supplements. Trained readers evaluated retinal/subretinal hemorrhage in baseline fundus photographs. Adjusted odds ratios from multivariate logistic regression models assessed the association between iron use and baseline hemorrhage adjusted by age, sex, smoking, hypertension, anemia, and use of antiplatelet/anticoagulant drugs. RESULTS: Among 1,165 participants, baseline retinal/subretinal hemorrhage was present in the study eye in 71% of 181 iron users and in 61% of 984 participants without iron use (adjusted odds ratio = 1.47, P = 0.04), and the association was dose dependent (adjusted linear trend P = 0.048). Iron use was associated with hemorrhage in participants with hypertension (adjusted odds ratio = 1.87, P = 0.006) but not without hypertension. The association of iron use with hemorrhage remained significant among hypertensive participants without anemia (adjusted odds ratio = 1.85, P = 0.02). CONCLUSION: Among participants of comparison of age-related macular degeneration treatments trials, the use of oral iron supplements was associated with retinal/subretinal hemorrhage in a dose-response manner. Unindicated iron supplementation may be detrimental in patients with wet age-related macular degeneration.
Subject(s)
Iron Compounds/adverse effects , Ranibizumab/administration & dosage , Retinal Hemorrhage/chemically induced , Visual Acuity , Wet Macular Degeneration/drug therapy , Administration, Oral , Aged , Aged, 80 and over , Angiogenesis Inhibitors , Dietary Supplements , Female , Fluorescein Angiography , Fundus Oculi , Humans , Intravitreal Injections , Iron Compounds/administration & dosage , Male , Retinal Hemorrhage/diagnosis , Tomography, Optical Coherence , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Wet Macular Degeneration/diagnosisABSTRACT
The use of interferon increased these last years. Cotton wool-spots, retinal hemorrhages, and microaneurysms are common manifestations of interferon retinopathy. The frequency of this retinopathy is underestimated as it is often asymptomatic. Screening and a multidisciplinary approach are therefore recommended.
Subject(s)
Interferons/adverse effects , Retinal Hemorrhage/chemically induced , Retinal Hemorrhage/prevention & control , Ginkgo biloba , Humans , Phytotherapy , Retinal Hemorrhage/diagnosis , Risk FactorsABSTRACT
PURPOSE: To describe a case of acute bilateral intraocular hemorrhages occurring after injection of oxygen-ozone (O(2)O(3)) mixture. DESIGN: Observational case report. METHODS: A 45-year-old woman complained about acute bilateral visual loss after intradiscal and periganglionic injection of gas mixture (O(2)O(3)) for lumbar disk herniation. Detailed ophthalmologic examination; magnetic resonance imaging (MRI) of brain and spinal cord; and neodymium:yttrium-aluminum-garnet (Nd:YAG) laser membranotomy in the left eye was performed. RESULTS: Ophthalmoscopy revealed a premacular hemorrhage involving the left macula. In the right eye multiple, flat, retinal hemorrhages around the optic disk and the posterior pole were observed. The MRI scan for intracranial hemorrhage was unremarkable. Drainage of the left premacular hemorrhage by pulsed Nd:YAG laser was obtained a few weeks later. CONCLUSIONS: Retinal hemorrhages seem to be an uncommon but significant complication of intradiscal O(2)O(3) infiltration, and we suggest that it should be carefully considered when recommending this procedure.
Subject(s)
Intervertebral Disc Displacement/therapy , Oxygen/adverse effects , Ozone/adverse effects , Retinal Hemorrhage/chemically induced , Vitreous Hemorrhage/chemically induced , Acute Disease , Drug Therapy, Combination , Female , Functional Laterality , Humans , Injections, Spinal , Lumbar Vertebrae , Magnetic Resonance Imaging , Middle Aged , Oxygen/therapeutic use , Ozone/therapeutic use , Retinal Hemorrhage/diagnosis , Retinal Hemorrhage/surgery , Vitreous Hemorrhage/diagnosis , Vitreous Hemorrhage/surgeryABSTRACT
PURPOSE: To report a case of retinal and choroidal vascular occlusion occurring as a complication after posterior sub-Tenon triamcinolone injection for treatment of uveitic cystoid macular edema. DESIGN: Interventional case report. METHODS: Retrospective study. A 32-year-old woman with uveitis and cystoid macular edema underwent a right posterior sub-Tenon injection of triamcinolone (40 mg/ml, 1 ml total) through a superotemporal approach after topical anesthesia. After the procedure, the patient experienced severe eye pain, orbital ecchymosis, and globe proptosis consistent with retrobulbar hemorrhage. RESULTS: Dilated fundus examination of the right eye (OD) demonstrated multiple intraretinal hemorrhages with particulate white emboli occluding the retinal and choroidal vessels. Visual acuity was no light perception. Ocular massage and hypotensive therapy was initiated for an intraocular pressure of 50 mm Hg. Canthotomy and cantholysis were performed. A total of 39 months post-incident, her visual acuity improved to 20/100. CONCLUSION: Posterior sub-Tenon triamcinolone injection can rarely result in retinal and choroidal occlusion. Immediate intervention may preserve limited visual acuity.