ABSTRACT
BACKGROUND: Equine sarcoids (ES) are the most common cutaneous tumors in equids. Systemic treatment options are sparse. Subcutaneous (SC) injections of Viscum album extract (VAE) demonstrate efficacy as a systemic treatment directed against ES. OBJECTIVES/AIM: To critically assess the therapeutic efficacy of orally administered VAE. ANIMALS: Forty-five ES-affected, privately owned, 3-12 year-old horses. METHODS: A 3-armed randomized placebo-controlled, double-blinded study was conducted in a double-dummy design. Horses were subjected to oral administration and SC injections of either VAE or placebo (VAE oral/placebo SC, VAE SC/placebo oral, placebo oral/placebo SC) over a 7-month treatment period. Primary endpoint was the change of baseline of a composite index of ES number and ES area after 14 months. Second endpoint was the clinical response. RESULTS: No statistically significant difference in the composite endpoint between the 3 study arms was found. The primary endpoint showed 4 (27%) horses in the VAE oral group with complete ES regression, 3 (21%) in the VAE SC injection group, and 2 (13%) in the placebo group. The clinical response revealed complete or partial regression in 6 horses of the oral VAE group (40%), 4 of the SC injection group (29%), and 4 of the placebo group (25%). Direct comparison of oral VAE and placebo showed an odds ratio, stratified for prognosis of 2.16 (95%-CI: 0.45-10.42) and a P-value of 0.336. CONCLUSION AND CLINICAL IMPORTANCE: Oral administration of VAE is well tolerated. No statistically significant difference in the effectiveness of systemic VAE versus placebo against ES was found.
Subject(s)
Horse Diseases , Plant Extracts , Animals , Horses , Horse Diseases/drug therapy , Plant Extracts/therapeutic use , Plant Extracts/administration & dosage , Administration, Oral , Injections, Subcutaneous/veterinary , Double-Blind Method , Female , Male , Skin Neoplasms/veterinary , Skin Neoplasms/drug therapy , Sarcoidosis/drug therapy , Sarcoidosis/veterinary , Viscum album/chemistryABSTRACT
The case report describes the surgical and photodynamic treatment (PDT) of an equine sarcoid in a 6-year-old gelding. A mass on the ventral prepuce, several tumours on the lateral aspect of the prepuce and one sarcoid on the front aspect of the chest were treated. For PDT, Temoporfin (Fospeg® Biolitec AG, Jena) at a concentration of 0.15mg/ml was injected locally. The subsequent irradiation was performed using a red-light laser (652nm) with an energy density of 10J/cm². The mass on the ventral aspect of the prepuce and some of the lateral tumours displayed total remission. The remaining tumours decreased in size or stopped growing.
Subject(s)
Horse Diseases/therapy , Photosensitizing Agents/therapeutic use , Phototherapy/veterinary , Sarcoidosis/veterinary , Animals , Combined Modality Therapy , Horse Diseases/drug therapy , Horse Diseases/pathology , Horse Diseases/surgery , Horses , Male , Sarcoidosis/drug therapy , Sarcoidosis/surgery , Sarcoidosis/therapyABSTRACT
Relata-se um caso de tratamento de sarcoide equino, mediante terapia do estado miasmatico (sicose). Observou-se nao apenas a regressao das multiplas massas tumorais, como tambem uma impressionante melhora do aspecto fisico e mental