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Emerging roles of steroid-binding globulins.

Caldwell, J D; Suleman, F; Chou, S H-H; Shapiro, R A; Herbert, Z; Jirikowski, G F.

Horm Metab Res ; 38(4): 206-18, 2006 Apr.

Article in English | MEDLINE | ID: mdl-16700000

Subject(s)

Receptors, Steroid/physiology , Sex Hormone-Binding Globulin/physiology , Androgen-Binding Protein , Animals , Brain/metabolism , Dihydrotestosterone/metabolism , Estradiol/metabolism , Female , GTP-Binding Proteins/metabolism , Humans , Male , Membrane Proteins/metabolism , Mice , Progesterone/metabolism , Rats , Receptors, Estradiol/metabolism , Sex , Yin-Yang

Potential anabolic effects of androgens on bone.

Kearns, Ann E; Khosla, Sundeep.

Mayo Clin Proc ; 79(4 Suppl): S14-8, 2004 Apr.

Article in English | MEDLINE | ID: mdl-15065633

ABSTRACT

Sex steroid hormones are essential to normal skeletal growth and maintenance throughout life in both men and women. The importance of estrogens to bone health in women becomes obvious at menopause when estrogen deficiency occurs and results in accelerated bone loss. After menopause, estrogen deficiency results in drastic changes in the androgen-estrogen ratio. Thus, the relative importance of androgens after menopause may increase. Androgens also appear to be important for bone health in pre-menopausal women. Evidence from human, animal, and laboratory studies is leading to a better understanding of the effects of androgens on bone in women.

Subject(s)

Androgens , Bone and Bones , Menopause , Androgen-Insensitivity Syndrome/drug therapy , Androgen-Insensitivity Syndrome/metabolism , Androgen-Insensitivity Syndrome/physiopathology , Androgens/deficiency , Androgens/physiology , Androgens/therapeutic use , Animals , Bone Density/drug effects , Bone Density/physiology , Bone and Bones/drug effects , Bone and Bones/physiology , Clinical Trials as Topic , Confounding Factors, Epidemiologic , Disease Models, Animal , Drug Evaluation, Preclinical , Estrogen Replacement Therapy/methods , Estrogens/deficiency , Estrogens/physiology , Estrogens/therapeutic use , Female , Hormone Replacement Therapy/methods , Humans , Male , Menopause/drug effects , Menopause/physiology , Polycystic Ovary Syndrome/drug therapy , Polycystic Ovary Syndrome/metabolism , Polycystic Ovary Syndrome/physiopathology , Premenopause/drug effects , Premenopause/physiology , Risk Factors , Sex Hormone-Binding Globulin/physiology , Women's Health

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