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1.
J Sports Med Phys Fitness ; 63(9): 964-973, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37212828

ABSTRACT

BACKGROUND: The aim of the present study was to determine the time-motion structure of high-level taekwondo matches during the Tokyo 2020 Olympic Games in relation to sex, match outcome, weight category and match round. METHODS: Overall, 7007 actions were recorded during the analysis of 134 performances (67 rounds of 24 matches: four rounds of 16, eight quarterfinals, eight semifinals and four finals) in male and female flyweight (≤58 kg and ≤49 kg, respectively), and heavyweight categories (≥80 kg and ≥67 kg, respectively). The attack time (AT), number of AT (AN), skipping time (ST) and pause time (PT) were registered. RESULTS: The AT/ST ratio was ~1:1.5. Male athletes performed significantly longer (P<0.001) sum PT than female athletes. Flyweight athletes differed significantly from their heavyweight counterparts by having longer (P<0.001) average and sum AT, greater (P<0.001) AN, higher (P<0.001) AT/ST ratio, shorter (P<0.001) average and sum ST, and lower (P<0.01) (AT+ST)/PT ratio. Rounds 2 and 3 had average PT significantly longer (P<0.01) than round 1. Round 3 had sum PT longer (P<0.001) and (AT+ST)/PT ratio lower than in round 1. CONCLUSIONS: The rule changes and the implementation of the electronic score recording system had a major impact on the time-motion structure of combat by generating a considerably higher AT/ST ratio than in the past. The comparisons indicated that the structure of the combat is modulated by weight category and phase of the combat. In practice, coaches could develop sport-specific high-intensity interval training using the time-motion indexes of the present study as guidelines.


Subject(s)
Martial Arts , Humans , Male , Female , Tokyo , Time and Motion Studies , Athletes
2.
Shokuhin Eiseigaku Zasshi ; 64(1): 13-20, 2023.
Article in Japanese | MEDLINE | ID: mdl-36858587

ABSTRACT

This study aimed to characterize the adverse events of dietary supplements provided by medical professionals and to examine whether there are challenges when applying each case to the causality evaluation algorithm. Data from 290 individual cases collected by the Tokyo Metropolitan Government in cooperation with the Tokyo Medical Association and Tokyo Pharmaceutical Association were analyzed. The causality evaluation algorithm that was used in this study was reported previously. Female patients accounted for 73% of those who experienced adverse events. Both male and female patients who had adverse events were in their 60s and 70s. Many of the participants had underlying diseases and aimed to improve their medical conditions. Furthermore, skin symptoms were the most common. Many of the supplements were made from natural substances, with an average of 7.7 ingredients in each product. More than half of the products were used for less than one month. In most cases, symptoms improved after discontinuation of the products or after the administration of medications. When each event was applied to the causality assessment algorithm, it was necessary to understand the information as follows: in cases of product discontinuation with simultaneous medications recovery was not concluding the product discontinuation, and the physician's judgement should be place as objective evidence. The algorithm was successfully applicable to cases provided by medical professionals and the evaluated results for all cases were 30% possible and 62% highly possible. The evaluated results indicate the relationship between products/ingredients and the symptom, and by adding information on the symptom and its severity, it is possible to clarify the phenomenon to be noted.


Subject(s)
Algorithms , Dietary Supplements , Humans , Female , Male , Tokyo
3.
Health Syst Reform ; 9(1): 2175415, 2023 12 31.
Article in English | MEDLINE | ID: mdl-36803509

ABSTRACT

The COVID-19 pandemic has caused serious disruptions to health systems across the world. While the pandemic has not ended, it is important to better understand the resilience of health systems by looking at the response to COVID-19 by hospitals and hospital staff. Part of a multi-country study, this study looks at the first and second waves of the pandemic in Japan and examines disruptions experienced by hospitals because of COVID-19 and the processes through which they overcame those disruptions. A holistic multiple case study design was employed, and two public hospitals were selected for the study. A total of 57 interviews were undertaken with purposively selected participants. A thematic approach was used in the analysis. The study found that in the early stages of the pandemic, faced with a previously unknown infectious disease, to facilitate the delivery of care to COVID-19 patients while also providing limited non-COVID-19 health care services, the case study hospitals undertook absorptive, adaptive, and transformative actions in the areas of hospital governance, human resources, nosocomial infection control, space and infrastructure management, and management of supplies. The process of overcoming the disruptions caused by the pandemic was complex, and the solution to one issue often caused other problems. To inform preparations for future health shocks and promote resilience, it is imperative to further investigate both organizational and broader health system factors that build absorptive, adaptive, and transformative capacity in hospitals.


Subject(s)
COVID-19 , Humans , COVID-19/epidemiology , Pandemics , Japan/epidemiology , Tokyo/epidemiology , Hospitals, Public
4.
Gan To Kagaku Ryoho ; 49(9): 994-996, 2022 Sep.
Article in Japanese | MEDLINE | ID: mdl-36156023

ABSTRACT

Since June 2019, cancer genome profiling(CGP)tests have been reimbursed by the National Health Insurance system in Japan and the number of CGP tests has been increasing. The expert panel, which is a molecular tumor board composed of multidisciplinary specialists, served as a place for education in cancer genomic medicine, but it has been forced to be simplified due to the increase in the number of cases. Furthermore, it takes time and effort to prepare the expert panel in advance, which is a burden in the medical field. Moreover, even if there are clinical trials that can be recommended by the expert panel, they are often conducted only in the Tokyo metropolitan area, and with the spread of the CGP testing, such" regional disparities"are becoming apparent.


Subject(s)
Genomics , Neoplasms , Humans , Japan , National Health Programs , Neoplasms/genetics , Neoplasms/therapy , Tokyo
5.
J Environ Radioact ; 255: 107011, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36137359

ABSTRACT

We examine the historical changes of 236U/238U and 235U/238U in a sediment core collected in Tokyo Bay and elucidate the anthropogenic sources of uranium in the 1960s-2000s. Uranium-236 was detected in samples deposited in the 1960s-2000s, and the 236U/238U ratio of the sediment core shows peak values in the 1970s. The 235U/238U isotopic ratios in samples deposited in the early 1960s are almost identical to that of natural uranium, implying that the 236U might have originated from global fallout. A decrease in 235U/238U was observed in the late 1960s-2000s, suggesting that depleted uranium from nuclear fuel reprocessing increased the 236U/238U ratios in the sediment. The 236U/238U values in sediments from the 1980s-2000s were lower than those in the 1970s but considerably higher than those in the 1960s, suggesting that the main source of depleted uranium still remains around Tokyo Bay. Our results demonstrated that the depleted uranium released in the 1970s should be considered as an important end-member when using uranium isotopic ratios as environmental tracers in closed aquatic environments around industrial cities.


Subject(s)
Radiation Monitoring , Uranium , Water Pollutants, Radioactive , Radiation Monitoring/methods , Uranium/analysis , Tokyo , Bays , Water Pollutants, Radioactive/analysis
6.
Zhonghua Yi Shi Za Zhi ; 52(4): 241-247, 2022 Jul 28.
Article in Chinese | MEDLINE | ID: mdl-36008314

ABSTRACT

More than 100 human bones, known as the Tokyo Human Bones, were found at the previous site of the Army Medical School in Tokyo, Japan, on July 22, 1989. They were located on the northern side of the previous location of the epidemic prevention research unit of the Army Medical School, with the discovery drawing a great deal of international attention. It was suggested that these bones might be from the victims of human experiments during World War II. It was found, in 1991, by Professor Sakura Shuo in Sapporo University, that the time and location of the burial of these bones was consistent with the existence of the Army Military Medical School. Most of these bones were Chinese, Korean and Mongolian races, and they were indeed closely related to the war. At the time they had not been found to be directly related to the human experiments of the Army Medical School, but the evidence left behind on the bones did not indicate gunshot or other war wounds, but evidence of medical experiments. This incident was known as the "Tokyo Bone Incident". Based on the research data on the Tokyo Human Bones internationally in the past 30 years, in particular, the testimony from the staff of the previous Army Medical School in Tokyo and members of the previous Army Medical School in Harbin (Unit 731), it can be concluded that some relationship exists between the Tokyo Human Bones and human experiments. This suggested that the nature of research related to these human bones conducted by the Army Medical School in Tokyo was consistent with those conducted at the Army Medical School in Harbin (Unit 731).


Subject(s)
Military Personnel , Schools, Medical , Humans , Schools, Medical/history , Tokyo , Universities , World War II
8.
Int J Soc Psychiatry ; 68(2): 253-263, 2022 Mar.
Article in English | MEDLINE | ID: mdl-33334208

ABSTRACT

BACKGROUND: Depression is an illness with biological, psychological, and social underpinnings, which may include the interplay of inflammation, psychological traits, stress, social relationships, and cultural background. AIMS: This work examines the prospective associations between social relationship quality and depressive symptoms, and between social relationship quality and inflammatory outcomes in two distinct cultures. METHODS: Data were obtained from two longitudinal, prospective cohort studies: Midlife in the United States (MIDUS), and Midlife Development in Japan (MIDJA) between 2004 and 2010. One thousand three hundred and twenty-seven community-based adults were included in analyses, 1,054 from the United States and 273 from Tokyo, Japan. Depressive symptoms (measured by the CES-D Depression Scale) and inflammation (measured by blood sample concentrations of the inflammatory biomarkers interleukin-6 and C-reactive protein) were the outcomes. Social relationship quality was the predictor. Culture, trait independence and interdependence, and psychosocial stressors were examined as moderators of the link between social relationship quality and depressive symptoms. RESULTS: Higher social relationship quality was associated with lower depressive symptoms in the United States (ß = -6.15, p < .001), but not in Japan (ß = -1.25, p = .390). Social relationship quality had no association with inflammation. Psychosocial stressors moderated the link between social relationship quality and depressive symptoms in both the United States (ß = -0.39, p = .001) and Tokyo (ß = -0.55, p = .001), such that social relationship quality acted as a buffer against depressive symptoms as psychosocial stress increased. CONCLUSION: Improving the perceived quality of social relationships appears to be a stronger target for depression interventions in the United States than in Tokyo, Japan.


Subject(s)
Cross-Cultural Comparison , Depression , Adult , Depression/epidemiology , Depression/psychology , Humans , Inflammation , Interpersonal Relations , Japan/epidemiology , Longitudinal Studies , Prospective Studies , Tokyo , United States/epidemiology
9.
Sci Total Environ ; 810: 151292, 2022 Mar 01.
Article in English | MEDLINE | ID: mdl-34756899

ABSTRACT

We examine the temporal changes of 236U/238U and 235U/238U in atmospheric deposition from samples collected in Tokyo and Akita from 1963 to 1979 and elucidate the spatial distribution and historical changes of the anthropogenic sources of uranium in Japan. The 236U/238U ratio of atmospheric deposition in Tokyo peaked in 1963 and again during the 1970s, while the corresponding 235U/238U ratios of atmospheric deposition during the second peak period were lower than that of natural uranium. The 236U/238U ratios of atmospheric deposition in Akita samples peaked in 1963. The 235U/238U ratios in Akita samples were almost identical to that of the natural uranium ratios. These results suggest that the peak of 236U/238U in 1963 corresponds to what is recognized as representative for global fallout. The increase of 236U/238U and the decrease of 235U/238U observed simultaneously in the 1970s indicate that depleted uranium has subsequently been released into the environment around Tokyo. The cumulative deposition density of 236U for atmospheric fallout samples collected in Tokyo from 1968 to 1979 is an order of magnitude larger than that of the global fallout, suggesting that the depleted uranium in the 1970s is a major component of 236U in Tokyo and should be considered as an end-member when using 236U as an environmental tracer in the industrial city. This knowledge can facilitate future research using 236U as an effective environmental tracer.


Subject(s)
Radiation Monitoring , Uranium , Cities , Japan , Tokyo , Uranium/analysis
10.
J Sports Med Phys Fitness ; 61(8): 1117-1124, 2021 Aug.
Article in English | MEDLINE | ID: mdl-34327976

ABSTRACT

BACKGROUND: Injury prevention strategies should be built upon data about the more frequent injuries in each specific sport. Therefore, this study aimed to describe the lifetime prevalence and characteristics of severe knee injuries among world-class karatekas. METHODS: A retrospective study based on a face-to-face survey was conducted. Participants were athletes who competed in World Karate Senior Championships in Madrid 2018, which was a tournament with the highest value to rank athletes to the Tokyo Olympic Games. A questionnaire was used to collect retrospective information on the prevalence and characteristics of severe knee injuries that occurred along elite karatekas sport careers. Odds Ratio (OR) were calculated to identify the association of sex and karate modality (kata / kumite) with severe knee injury risk. RESULTS: Out of the 293 athletes surveyed (23.4±4.0 years; 137 female), 71 (24.2%) had suffered a serious knee injury at some point of their careers, without a statistically significant difference between male and female athletes. There was no difference between the percentage of injuries that took place during training (54.9%) or during competition (45.1%) both in male and female athletes. Kumite athletes suffered more knee injuries during competition than training. The most common injury mechanism for both genders was a pivoting or dodging movement (36.4% in males and 39.5% in females). CONCLUSIONS: The information presented in this study about the prevalence and characteristics (mechanism, anatomical location, moment, time off) of the severe knee injuries in elite karatekas could be useful to design prevention programs to be implemented among karate athletes.


Subject(s)
Athletic Injuries , Knee Injuries , Martial Arts , Athletes , Athletic Injuries/epidemiology , Female , Humans , Knee Injuries/epidemiology , Male , Retrospective Studies , Tokyo
11.
Sci Total Environ ; 788: 147623, 2021 Sep 20.
Article in English | MEDLINE | ID: mdl-34023597

ABSTRACT

Airborne pollens cause pollinosis and have the potential to affect microphysics in clouds; however, the number of monitored species has been very limited due to technical difficulties for the morphotype identification. In this study, we applied an eDNA approach to the airborne pollen communities in the suburbs of the Tokyo metropolitan area in Japan, within a mixed urban, rural, and mountain landscape, revealing pollen seasonality of various taxa (a total of 78 families across the period) in the spring season (February to May). Those taxa distinctly shifted in the season, especially in the beginning of February and the middle of April. Air temperature shift was an obvious key factor to affect the airborne pollen community, while the influence of other meteorological factors, such as wind speed, humidity, and precipitation, was not clear. Taxonomic classification of major Amplicon Sequence Variants (ASVs) indicates multiple pollen sources, including natural forest, planted forest, roadside, park lands, and horticultural activities. Most major ASV belongs to Japanese cedar (Cryptomeria japonica), which is the most notable allergen that causes pollinosis in Japan, peaking in mid-February to March. Backward trajectory analysis of air masses suggests that the Japanese cedar and other Cupressaceae plantation forests in the western mountains were a significant source of airborne pollen communities detected at our sampling site. Other major plant pollen sources, including Japanese zelkova (Zelkova serrata) and ginkgo (Ginkgo biloba), emanated from the nearby parks or roadside regions. This study's approach enables us to visualize the phenology of multiple pollen, including timing and duration. Long-term monitoring of this type would provide additional insight into understanding the role of climate change on pollen transmission and links to flowering events.


Subject(s)
Cryptomeria , Pollen , Allergens , Humans , Japan , Seasons , Tokyo
12.
Med Mycol ; 59(4): 327-334, 2021 Apr 06.
Article in English | MEDLINE | ID: mdl-32642756

ABSTRACT

The prevalence of azole-resistant Aspergillus fumigatus (ARAF) among chronic pulmonary aspergillosis (CPA) patients treated with azoles in Japan is unknown. The aim of this study was to determine the detection rate of ARAF in isolates from CPA patients who were treated with azoles for varying durations. The potential mechanism of acquiring resistance was examined by sequencing cyp51A and hmg1, two genes associated with ARAF. A. fumigatus isolates (n = 120) were collected from CPA patients (n = 104) between February 2012 and February 2019, at National Hospital Organization Tokyo National Hospital. The isolates were tested for susceptibility to the azole drugs itraconazole (ITCZ) and voriconazole (VRCZ). The detection rate of ARAF among all isolates was 8.3% (n = 10). Of the 10 resistant isolates, eight were ITCZ-resistant and five were VRCZ-resistant. Among 47 isolates obtained from 36 CPA patients who were treated with ITCZ (for an average of 256 days) and/or VRCZ (for an average of 29 days), the resistance rates were 17.0% and 10.6%, respectively. In addition, 46.2% of 13 isolates obtained from CPA patients with ongoing azole treatment at the time of antifungal therapy failure were resistant to azoles. Among the 10 ARAF isolates, a point mutation was detected in cyp51A in seven isolates and in hmg1 in two isolates. ARAF was detected at a high rate in CPA patients, particularly in those with ongoing long-term azole treatment, at the time of azole antifungal therapy failure.


Aspergillus fumigatus can acquire azole resistance during long-term treatment with azole drugs in patients with chronic pulmonary aspergillosis (CPA). The aim of this study was to determine the detection rate of azole-resistant A. fumigatus (ARAF) in isolates from CPA patients who had been treated with azoles. In addition, a potential mechanism of acquiring resistance was examined by sequencing cyp51A and hmg1, two genes associated with ARAF. A. fumigatus isolates (n = 120) were collected from CPA patients (n = 104). The isolates were tested for susceptibility to the azole drugs itraconazole (ITCZ) and voriconazole (VRCZ). The detection rate of ARAF from all isolates was 8.3% (n = 10). Greater than 10% of the 47 isolates obtained from 36 CPA patients who had been treated with azoles exhibited resistance. Furthermore, 46.2% of 13 isolates obtained from CPA patients with ongoing azole treatment at the time of antifungal therapy failure were resistant to azoles. Among the 10 ARAF isolates, a point mutation was detected in cyp51A in seven isolates and in hmg1 in two isolates. ARAF was detected at a high rate in CPA patients undergoing long-term azole treatment at the time of antifungal therapy failure.


Subject(s)
Antifungal Agents/pharmacology , Aspergillus fumigatus/drug effects , Azoles/pharmacology , Azoles/therapeutic use , Drug Resistance, Fungal/genetics , Hospitals/statistics & numerical data , Pulmonary Aspergillosis/drug therapy , Aged , Aspergillus fumigatus/genetics , Azoles/classification , Chronic Disease/therapy , Female , Fungal Proteins/genetics , Genotype , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Prevalence , Pulmonary Aspergillosis/epidemiology , Pulmonary Aspergillosis/microbiology , Retrospective Studies , Tokyo/epidemiology
13.
BMC Res Notes ; 13(1): 515, 2020 Nov 10.
Article in English | MEDLINE | ID: mdl-33168068

ABSTRACT

OBJECTIVE: Apis mellifera is a species of honeybee that has been introduced around the world as an industrial beekeeping species. Recently, urban beekeeping has attracted attention as a means of ecosystem protection and urban greening. This study aimed to investigate nectar sources of urban beekeeping in Koto-ku, Tokyo using pollen DNA metabarcoding. RESULTS: We extracted DNA from pollen collected by the honeybees of a local urban beekeeping operation. DNA metabarcoding analysis was carried out by sequencing a part of the rbcL region of the chloroplast genome. A total of 31 samples collected between mid-March, 2018 and mid-October, 2018 yielded 54 operational taxonomic units (OTUs) comprising 14 families, 32 genera, and 8 species. Whereas 5 OTUs were profiled throughout all seasons, 38 OTUs were season-specific (spring, summer, or autumn). Therefore, we were able to infer seasonal nectar sources for the beekeeping operation at the family or genus level, as well as at the species level to a lesser extent. Our pollen-sampling strategy was effective for profiling season-specific nectar sources, with the exception of a few anomalies that can be accounted for by out-of-season flowering associated with artificial gardening and/or pollen accumulation over multiple seasons.


Subject(s)
Beekeeping , Plant Nectar , Animals , Bees/genetics , DNA , DNA Barcoding, Taxonomic , Ecosystem , Humans , Pollen/genetics , Tokyo
14.
J Clin Psychopharmacol ; 40(6): 599-606, 2020.
Article in English | MEDLINE | ID: mdl-33044355

ABSTRACT

BACKGROUND: Zinc plays an important role in appetite regulation. L-Carnosine, an endogenous dipeptide, may also regulate eating behavior via its histaminergic and antiglutamatergic properties. Polaprezinc (zinc-L-carnosine complex) is a medication for gastric ulcers. A small case series reported successful treatment of binge eating with add-on polaprezinc. METHODS: This was an open trial of add-on polaprezinc in patients with binge eating disorder (BED; n = 22) or bulimia nervosa (BN; n = 7) receiving antidepressants. A 4-week baseline period was followed by a 16-week polaprezinc treatment at 150 mg/d (containing 34 mg zinc and 116 mg L-carnosine) in addition to ongoing psychotropic medications. We also assessed their zinc status via a laboratory index and zinc deficiency-related symptoms. RESULTS: At the study end, both conditions showed a significant reduction in the 4-week frequency of combined objective and subjective binge eating episodes, the 4-week frequency of days when at least 1 such episode occurred (only in BED), several aspects of eating disorder psychopathology (rated by the Eating Disorder Examination-Questionnaire), and comorbid depressive symptoms (rated by the 16-item Quick Inventory of Depressive Symptomatology [Self-Report]). Serum copper/zinc ratio decreased from 1.4 to 1.1 on average in both conditions. All patients had multiple zinc deficiency-related symptoms at baseline that substantially improved after polaprezinc treatment. Overall, the effectiveness of polaprezinc was greater in BED patients than in BN patients, with minor adverse effects. CONCLUSIONS: These findings offer preliminary evidence for the effectiveness of polaprezinc in treating BED and BN and suggest the involvement of zinc deficiency in these conditions.


Subject(s)
Antidepressive Agents/therapeutic use , Binge-Eating Disorder/drug therapy , Bulimia Nervosa/drug therapy , Carnosine/analogs & derivatives , Dietary Supplements , Feeding Behavior/drug effects , Organometallic Compounds/therapeutic use , Zinc/deficiency , Adult , Antidepressive Agents/adverse effects , Binge-Eating Disorder/blood , Binge-Eating Disorder/diagnosis , Binge-Eating Disorder/psychology , Biomarkers/blood , Bulimia Nervosa/blood , Bulimia Nervosa/diagnosis , Bulimia Nervosa/psychology , Carnosine/adverse effects , Carnosine/therapeutic use , Dietary Supplements/adverse effects , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Organometallic Compounds/adverse effects , Pilot Projects , Prospective Studies , Time Factors , Tokyo , Treatment Outcome , Young Adult , Zinc/blood , Zinc Compounds/adverse effects , Zinc Compounds/therapeutic use
15.
Leg Med (Tokyo) ; 47: 101739, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32645558

ABSTRACT

In Japan over the past few years, approximately 13,000 individuals were arrested for drug offenses each year. It is useful to know the trends in drug offenses, in order to devise the most effective countermeasures and addiction treatment programs. Herein, we have revealed the trends in drug offenses in the Tokyo Metropolitan Area. This report was researched the number of individuals arrested for drug offenses in Tokyo during the 3-year study period 2016-2018. The drugs are classified into the six categories: stimulants, narcotics, psychoactive drugs, opium, cannabis, and designated substances. We also calculated the percentages of individuals arrested for various drug offenses based on these six categories. Approximately 86% of the arrests for drug offenses in Tokyo during the 3-year period were for stimulants or cannabis. A higher percentage of individuals were arrested for stimulants, but the percentage of individuals arrested for cannabis increased each year. Given the percentage of individuals arrested for designated substances or narcotics, preventive measures for drug offenses involving stimulants and cannabis should be promptly implemented. Further campaigns to prevent drug offenses and public lectures are also needed. Public education must be provided to prevent drug offenses involving designated substances and narcotics.


Subject(s)
Crime/statistics & numerical data , Crime/trends , Illicit Drugs , Cannabis , Central Nervous System Stimulants , Crime/prevention & control , Designer Drugs , Humans , Illicit Drugs/classification , Narcotics , Opium , Psychotropic Drugs , Tokyo/epidemiology
16.
J Infect Dev Ctries ; 14(4): 328-331, 2020 04 30.
Article in English | MEDLINE | ID: mdl-32379708

ABSTRACT

The COVID-19 pandemic is novel corona virus infection outbreak that has gone global in 2020. Current prevention policies consist of hand hygiene and social distancing. Emergencies overloaded health services and shocked the logistics chains in many countries, especially Italy and China. Having more than a quarter of its population being elderly, Japan is at high risk for COVID-19 induced morbidity and mortality. This situation cancelled schedules of all routine group exercise activities for the seniors in Japan. While the outbreak is ongoing, staying at home is safe. However, successive days of being house-ridden and limited movement can lead to excessive physical inactivity. Some elderly who are not moving much can lose a significant amount of muscle strength, flexibility and aerobic capacity. It can accelerate the frailty and dependency of the seniors, and subsequently, claiming of care and health services. Moreover, existing and new evidences showed that physical activity can promote antiviral immunity. An alternative to usual group exercise activities is crucial to keep seniors active without affecting social distancing. While staying at home for long, functional exercises maintaining basic level of physical activity and movements are urgently required to be introduced to the seniors in Tokyo and around the world to prevent functional decline. Home exercise is a practical option. Therefore, we made a home-version of the functional training exercise video with different sets of 10-minutes exercise for 7 days a week. This breakthrough alternative may sustain health promotion for the elderly persons to preserve their active aging and maintain optimal health.


Subject(s)
Coronavirus Infections/prevention & control , Coronavirus , Disease Outbreaks/prevention & control , Health Promotion/methods , Pandemics , Pneumonia, Viral/prevention & control , Aged , Betacoronavirus , COVID-19 , Coronavirus Infections/epidemiology , Exercise , Health Promotion/organization & administration , Humans , Japan , Pandemics/prevention & control , Pneumonia, Viral/epidemiology , Public Health , SARS-CoV-2 , Telemedicine , Tokyo
17.
Shokuhin Eiseigaku Zasshi ; 61(1): 34-40, 2020.
Article in English | MEDLINE | ID: mdl-32336717

ABSTRACT

Some illegal dietary supplements contain phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, for exerting "therapeutic" effects in erectile dysfunction. This is apparently dangerous, and thus, should be appropriately regulated. Identification of descarbonsildenafil was first reported in Singapore in a coffee sample labeled to exert male sexual performance enhancement effects. However, it is unclear whether the compound possesses PDE5 inhibitory activity. We encountered during our survey of dietary supplements, a sexual enhancement product commercially available in Tokyo, in which a peak presumed to be of descarbonsildenafil was detected by LC-UV and electrospray ionization-tandem MS (ESI-MS/MS). The compound was isolated and identified as descarbonsildenafil with liquid chromatography-quadrupole time-of-flight-mass spectrometry (LC-QTOF-MS), NMR, and X-ray crystal structural analysis. In addition, descarbonsildenafil showed PDE5 inhibitory activity in PDE5 inhibition assay, and its IC50 value for PDE5A1 was found to be 30 nmol/L. The results of INADEQUATE NMR and X-ray crystal structural analysis in this study provide information for the identification of descarbonsildenafil. Since this study indicates that this compound is a PDE5 inhibitor having adequate activity, it is regulated as a drug component in Japan.


Subject(s)
Dietary Supplements , Food Contamination , Phosphodiesterase 5 Inhibitors/analysis , Sildenafil Citrate/analysis , Tandem Mass Spectrometry , Cyclic Nucleotide Phosphodiesterases, Type 5 , Tokyo
18.
BMC Cardiovasc Disord ; 20(1): 160, 2020 04 06.
Article in English | MEDLINE | ID: mdl-32252654

ABSTRACT

BACKGROUND: Previous studies have reported that being overweight, obese, or underweight is a risk factor for ischemic cardiovascular disease (CVD); however, CVD also occurs in subjects with ideal body mass index (BMI). Recently, the balance of n-3/n-6 polyunsaturated fatty acids (PUFAs) has received attention as a risk marker for CVD but, so far, no study has been conducted that investigates the association between BMI and the balance of n-3/n-6 PUFAs for CVD risk. METHODS: We evaluated the association between n-3/n-6 PUFA ratio and acute coronary syndrome (ACS) in three BMI-based groups (< 25: low BMI, 25-27.5: moderate BMI, and ≥ 27.5: high BMI) that included 1666 patients who visited the cardiovascular medicine departments of five hospitals located in urban areas in Japan. RESULTS: The prevalence of ACS events was 9.2, 7.3, and 10.3% in the low, moderate, and high BMI groups, respectively. We analyzed the relationship between ACS events and several factors, including docosahexaenoic acid/arachidonic acid (DHA/AA) ratio by multivariate logistic analyses. In the low BMI group, a history of smoking (odds ratio [OR]: 2.47, 95% confidence interval [CI]: 1.40-4.35) and low DHA/AA ratio (OR: 0.30, 95% CI: 0.12-0.74) strongly predicted ACS. These associations were also present in the moderate BMI group but the magnitude of the association was much weaker (ORs are 1.47 [95% CI: 0.54-4.01] for smoking and 0.63 [95% CI: 0.13-3.10] for DHA/AA). In the high BMI group, the association of DHA/AA (OR: 1.98, 95% CI: 0.48-8.24) was reversed and only high HbA1c (OR: 1.46, 95% CI: 1.03-2.08) strongly predicted ACS. The interaction test for OR estimates (two degrees of freedom) showed moderate evidence for reverse DHA/AA ratio-ACS associations among the BMI groups (P = 0.091). CONCLUSIONS: DHA/AA ratio may be a useful marker for risk stratification of ACS, especially in non-obese patients.


Subject(s)
Acute Coronary Syndrome/blood , Fatty Acids, Omega-3/blood , Fatty Acids, Omega-6/blood , Acute Coronary Syndrome/diagnosis , Acute Coronary Syndrome/epidemiology , Aged , Biomarkers/blood , Body Mass Index , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Obesity/diagnosis , Obesity/epidemiology , Predictive Value of Tests , Prevalence , Prognosis , Risk Assessment , Risk Factors , Tokyo/epidemiology
19.
Microbes Environ ; 35(2)2020.
Article in English | MEDLINE | ID: mdl-32147604

ABSTRACT

To identify exoelectrogens involved in the generation of electricity from complex organic matter in coastal sediment (CS) microbial fuel cells (MFCs), MFCs were inoculated with CS obtained from tidal flats and estuaries in the Tokyo bay and supplemented with starch, peptone, and fish extract as substrates. Power output was dependent on the CS used as inocula and ranged between 100 and 600 mW m-2 (based on the projected area of the anode). Analyses of anode microbiomes using 16S rRNA gene amplicons revealed that the read abundance of some bacteria, including those related to Shewanella algae, positively correlated with power outputs from MFCs. Some fermentative bacteria were also detected as major populations in anode microbiomes. A bacterial strain related to S. algae was isolated from MFC using an electrode plate-culture device, and pure-culture experiments demonstrated that this strain exhibited the ability to generate electricity from organic acids, including acetate. These results suggest that acetate-oxidizing S. algae relatives generate electricity from fermentation products in CS-MFCs that decompose complex organic matter.


Subject(s)
Acetates/metabolism , Bacteria/metabolism , Bioelectric Energy Sources/microbiology , Electricity , Geologic Sediments/microbiology , Shewanella/metabolism , Bacteria/classification , Electrodes , Fermentation , Microbiota/genetics , RNA, Ribosomal, 16S/genetics , Shewanella/genetics , Tokyo
20.
J Cardiovasc Electrophysiol ; 31(2): 440-449, 2020 02.
Article in English | MEDLINE | ID: mdl-31916643

ABSTRACT

INTRODUCTION: The voltage map during sinus rhythm (SR) is a cornerstone of substrate mapping (SM) in scar-related ventricular tachycardia (VT) and frequently used with pace mapping (PM). Where to conduct PM is unclear in cases of an extensive or unidentified substrate. Conduction properties are another aspect incorporated by SM, and conduction slowing has gained interest as being related to successful ablation, although its mechanism has not been elucidated. We aimed to investigate the relationship between SR conduction properties and VT isthmuses. METHODS: Nineteen patients (mean age, 62 years) who underwent VT ablation with voltage mapping and PM were reviewed. Isochronal late activation maps (ILAMs) with eight zones were reconstructed and sequentially named from one to eight according to the SR propagation. Good PM sites were superimposed on ILAMs, and the isthmus was defined using different pacing latencies. ILAM properties harboring isthmuses were investigated. RESULTS: Twenty-eight ILAMs (13 epicardium, 1 right ventricular [RV], and 14 left ventricular [LV] endocardium) were reviewed. Eighteen isthmuses of 24 target VTs were identified, in which the proximal ends were in a later zone than the distal ends (zone 6 vs 4; P < .001), suggesting a reverse isthmus vector to the SR. The conduction velocity of the zone involving the distal isthmus was significantly lower than that of the SR preceding zone (0.40 vs 1.30 m/s; P < .001). SR conduction velocity decelerated by 69.5% (range 59.7%-74.5%) before propagating into the isthmus area. CONCLUSION: Conduction slowing area during SR were related with the exit portion of the VT isthmuses.


Subject(s)
Heart Conduction System/physiopathology , Heart Rate , Tachycardia, Ventricular/physiopathology , Action Potentials , Adult , Aged , Aged, 80 and over , Catheter Ablation , Electrophysiologic Techniques, Cardiac , Female , Humans , Male , Middle Aged , Retrospective Studies , Tachycardia, Ventricular/diagnosis , Tachycardia, Ventricular/surgery , Time Factors , Tokyo
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