Management of Inverted Papilloma During Holmium Laser Enucleation of the Prostate.

Inverted papilloma of the prostatic urethra is an especially rare finding. A 75-year-old man with urinary retention wished to proceed with a holmium laser enucleation of the prostate (HoLEP) and was found to have a mass arising from his prostate vs bladder on preoperative imaging. Cystourethroscopy revealed the mass arising from the median lobe of the prostate. After transurethral resection and frozen analysis confirmed the benign pathology of an inverted papilloma, the patient subsequently underwent a successful HoLEP during the same surgical setting. Images of this rare prostatic mass are presented to increase urologist recognition and to assist management during HoLEP.

Adenoma nefrogénico de localización prostática. Aportación de un caso / Prostatic nephrogenic adenoma. Case report

OBJETIVO: Presentamos el caso de un adenoma nefrogénico de uretra prostática como hallazgo incidental tras una resección trasuretral de próstata.MÉTODO/RESULTADO: Se trata del diagnóstico incidental de adenoma nefrogénico de uretra prostática en varón de 50 años intervenido de hiperplasia benigna prostática mediante resección trasuretral.CONCLUSIONES: El adenoma nefrogénico es una lesión benigna del tracto urinario, infrecuente, asociado con una historia previa de traumatismo o irritación sobre el urotelio. Los factores predisponentes incluyen las infecciones, cálculos, cirugía, traumatismos y el trasplante renal(AU)

OBJECTIVE: We present a case of prostatic urethra nephrogenic adenoma as an incidental finding following transurethral resection of the prostate.METHOD/RESULT: It is an incidental diagnosis of nephrogenic adenoma of prostatic urethra in a 50-year-old male operated for benign prostatic hyperplasia by means of transurethral resection.CONCLUSIONS: Nephrogenic adenoma is an infrequent and benign lesion of the urinary tract, associated with a previous history of trauma or irritation on the urothelium. Predisposing factors include infections, calculi, surgery, trauma and kidney transplantation(AU)

Surgical excision of strangulated urethral prolapse mimicking urethral carcinoma under local anesthesia in a postmenopausal woman.

Urethral prolapse is frequently reported in girls; however, the clinical condition is frequently encountered in postmenopausal women by urologists and gynecologists. The treatment of urethral prolapse is controversial. Information regarding the treatment and pathophysiology of this clinical entity in postmenopausal women is sparse in the published literature. We report a case of strangulated urethral prolapse that was successfully treated by surgical excision under local anaesthesia.

Papiloma invertido. Aportación de dos casos y revisión de la literatura / Inverted papilloma. Report of two cases and bibliographic review

Objetivo: El papiloma invertido es una rara lesión polipoidea del urotelio, conocida como entidad diferente desde 1963, desde cuando escasamente se han publicado más de 100 casos en la literatura. Aunque su potencial maligno es todavía desconocido, existen varias publicaciones científicas en las que se denota. Métodos: Presentamos dos casos de papiloma invertido y hacemos una detallada revisión de la literatura científica al respecto. Resultados: Ambos pacientes fueron diagnosticados por el servicio de Anatomía Patológica de papiloma invertido, siguiendo controles periódicos posteriores y no apareciendo recidivas en ninguno de los dos casos, a los 24 y 18 meses de seguimiento respectivamente. Conclusiones: La posibilidad de que el papiloma invertido sea una lesión con potencial maligno debe ser en todo caso considerada y sugerimos que los pacientes con este diagnóstico sean sometidos a los exámenes urológicos de seguimiento en cualquier neoplasia vesical (AU)

Objective: Inverted papilloma is a rare polypoid lesion of the urothelium, known as a different entity since 1963. Not many more than 100 cases have been published. Although its malignant potential is still unknown, several scientific publications have noted it. Methods: We report to cases of inverted papilloma and perform a detailed bibliographic review. Results: Both patients were diagnosed by the Pathology Department and entered periodic follow-up visits, being free of recurrence at 24 and 18 months respectively. Conclusions: The possibility that inverted papilloma is a lesion with malignant potential should be considered in every case, and we suggest that patients with this diagnosis should enter a follow-up protocol like any bladder neoplasia (AU)

Prolapso de uretra / Urethral prolapse

El prolapso uretral en la mujer es infrecuente. Se define como la completa eversión de la mucosa uretral a través del meato. Ocurre frecuentemente en mujeres negras prepúperes y en mujeres blancas posmenopáusicas. El tratamiento recomendado incluye desde la terapia conservadora hasta múltiples intervenciones quirúrgicas (AU)

Prolapse of the urethra in female patients is a rare events. It is defined as the complete eversion of the urethral mucosa through the external meatus. It occurs most often in pre-puberal black girls and in postmenopausal white women. Recommended treatment ranges from conservative therapy to a diversity of operative techniques (AU)

Treatment of urethral recurrence following radical cystectomy and ileal bladder substitution.

PURPOSE: With the introduction of orthotopic bladder substitution after radical cystectomy in patients with invasive bladder cancer urethral recurrences have become a therapeutic challenge. MATERIALS AND METHODS: We retrospectively evaluated our patients with urethral recurrences treated with a urethra sparing approach after orthotopic bladder substitution. Depending on the extension of recurrence and eventual concomitant metastases patients were treated with urethrectomy, no treatment, systemic chemotherapy or intraurethral bacillus Calmette-Guerin (BCG). Three times the common dose of BCG (ImmuCyst, Aventis, Paris, France or OncoTICE, Organon, West Orange, New Jersey) in 150 ml NaCl 0.9% was used for intraurethral BCG perfusion therapy according to an institutional protocol using a modified Foley catheter. This regimen was repeated weekly for 6 weeks and patients were followed prospectively. RESULTS: Between 1985 and 2001, 15 of 371 patients (4%) who received an orthotopic bladder substitute had urethral recurrence. Two patients were treated with systemic chemotherapy (methotrexate, vinblastine, doxorubicin and cisplatin) alone due to metastatic disease and 10 received intraurethral BCG therapy. Five of 6 patients (83%) with carcinoma in situ remained free of recurrence following treatment with BCG, while in 4 with papillary or invasive disease treatment failed. Three patients underwent urethrectomy, including 2 following failed BCG therapy for papillary disease. CONCLUSIONS: Carcinoma in situ urethral recurrence following orthotopic bladder substitution can be treated successfully with intraurethral BCG perfusion therapy in approximately 80% of patients. However, papillary and invasive transitional cell urethral recurrence should be treated with urethrectomy.

Adenocarcinoma of the female urethral diverticulum treated by multimodality therapy.

A 75-year-old female presented with a 7-month history of intermittent macrohematuria and urinary retention. Physical examination revealed a firm, round mass on the anterior vaginal wall. The diagnosis by urethroscopy and radiological evaluation was localized urethral diverticular tumor. Pathological examination of the biopsy specimen revealed adenocarcinoma. The patient received two courses of intra-arterial and systemic chemotherapy using cisplatin, 5-fluorouracil and leucovorin, followed by radiation to the urethra. The tumor shrunk markedly after chemotherapy. The patient underwent total urethrectomy and vesicostomy. Two years after the operation, she had no evidence of recurrence. Adenocarcinoma of the female urethral diverticulum is rare and has been treated by surgery and/or radiation. The present case is the first case of it being treated by multimodality therapy including chemotherapy.

Management of condyloma acuminatum.

This article describes an approach to the evaluation and treatment of condyloma acuminatum (anogenital warts) that is based on the results of new clinical research on the biology of the human papillomavirus. A more extensive diagnostic protocol, including routine cervicovaginal examination and Papanicolaou smear, is proposed for female patients because of the close association of genital human papillomavirus infections with cervical carcinoma. Two highly effective therapies, cryosurgery and carbon dioxide laser photocoagulation, are described and compared with older regimens. Recent developments in immunotherapy for resistant condyloma acuminatum are also discussed.