RESUMEN
Prostaglandin E2 (PGE2, 0.5 - 5 nmol/kg) injected into the lateral cerebral ventricle of the rat increased the systemic blood pressure and heart rate in a dose dependent manner. These effects were accompanied by increases in plasma norepinephrine and epinephrine concentration. Injection of low dose of prostaglandin E2 into discrete hypothalamic nuclei induced a marked increase in heart rate, a moderate increase in the arterial blood pressure and a significant elevation of plasma norepinephrine level. This study suggests a possible central role for PGE2 in modulation of cardiovascular dynamics and sympathetic nervous activity.
Asunto(s)
Presión Sanguínea/efectos de los fármacos , Fenómenos Fisiológicos Cardiovasculares , Frecuencia Cardíaca/efectos de los fármacos , Hipotálamo/fisiología , Prostaglandinas E/farmacología , Sistema Nervioso Simpático/fisiología , Animales , Dinoprostona , Epinefrina/sangre , Hipotálamo/efectos de los fármacos , Cinética , Masculino , Norepinefrina/sangre , Ratas , Ratas Endogámicas , Sistema Nervioso Simpático/efectos de los fármacosRESUMEN
Injection of prostaglandin F2 alpha (1 nmol/rat) into the paraventricular, dorsomedial and posterior hypothalamic nuclei of halothane anesthetized rats elicited rapid increases of heart rate and blood pressure. The injection of this same dose of prostaglandin F2 alpha into the cerebroventricular system or intravenously had no effect on these parameters. The cardiovascular responses observed following prostaglandin F2 alpha injection into these hypothalamic nuclei were accompanied by increases in plasma levels of norepinephrine and epinephrine, with peak levels at the maximal cardiovascular response. This study suggests a possible role for prostaglandin F2 alpha in modulation of the cardiovascular system via specific hypothalamic nuclei.