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Biomed Chromatogr ; 32(2)2018 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28913959

RESUMEN

The rise of the mosquitoes-transmitted diseases, like dengue, zika and chikungunya in Brazil in the last years has increased concerns on protection against mosquitoes bites. However, the prohibitive prices of the commercially available repellents for the majority of the Brazilian population has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of Indian clove (Syzygium aromaticum L.) as repellent, which has been reported as quite efficient by the local press. In order to verify this, we performed here the quantification of the main components of this extract through high-performance thin-layer chromatography (HPTLC)-densitometry and evaluated its efficiency as a repellent and its acetylcholinesterase (AChE) inhibition capacity. Our results have proved HPTLC-densitometry as an efficient and appropriate method for this quantification and confirmed the repellency activity, as well as its capacity of AChE inhibition.


Asunto(s)
Inhibidores de la Colinesterasa , Cromatografía en Capa Delgada/métodos , Repelentes de Insectos , Extractos Vegetales , Syzygium/química , Acetilcolinesterasa/metabolismo , Adulto , Aedes/efectos de los fármacos , Animales , Conducta Animal/efectos de los fármacos , Inhibidores de la Colinesterasa/análisis , Inhibidores de la Colinesterasa/química , Inhibidores de la Colinesterasa/farmacología , Densitometría , Eugenol/análisis , Eugenol/química , Eugenol/farmacología , Humanos , Repelentes de Insectos/análisis , Repelentes de Insectos/química , Repelentes de Insectos/farmacología , Límite de Detección , Modelos Lineales , Masculino , Extractos Vegetales/análisis , Extractos Vegetales/química , Extractos Vegetales/farmacología , Reproducibilidad de los Resultados , Adulto Joven
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