RESUMEN
Histological changes observed under light microscope illustrate follicular degeneration in ovary, vacuolation and mild disorganization of uterus on treatment with graded doses of alcohol seed extract of Caesalpinia bonducella. There was a significant decrease (p≤0.05) in duration of estrous cycle and mean ovarian weight. However, there were no uniform variations in mean uterine weight, serum estradiol and progesterone level. The results suggest that alcohol seed extract of C. bonducella has antiestrogenic property, possibly acting via inhibition of estrogen secretion.
Asunto(s)
Caesalpinia , Moduladores de los Receptores de Estrógeno/farmacología , Ovario/efectos de los fármacos , Extractos Vegetales/farmacología , Útero/efectos de los fármacos , Animales , Caesalpinia/química , Relación Dosis-Respuesta a Droga , Estradiol/sangre , Moduladores de los Receptores de Estrógeno/química , Moduladores de los Receptores de Estrógeno/aislamiento & purificación , Ciclo Estral/sangre , Ciclo Estral/efectos de los fármacos , Femenino , Tamaño de los Órganos , Ovario/metabolismo , Ovario/patología , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Progesterona/sangre , Ratas , Ratas Wistar , Semillas , Útero/metabolismo , Útero/patologíaRESUMEN
Morphological changes in the sperm of albino rats observed under scanning electron microscope illustrate the disturbance in the plasma membrane, as well as in the acrosomal membrane upon treatment with graded doses of an alcoholic seed extract of Caesalpinia bonducella. Considerable changes in the shape and size of the sperm head were observed, with the middle region of the sperm head being slightly constricted dorsoventrally. Most sperm appeared morphologically abnormal in the head region showing the distortion at the anterior region and bulging of the acrosomal membrane when compared with the control. The results of this study suggest that such effects might have resulted from general disturbance in proteins and alteration in the cauda epididymal milieu, probably due to an androgen deficiency consequent to the treatment with Caesalpinia bonducella.