Combined nonablative skin rejuvenation with the 595- and 1450-nm lasers.

BACKGROUND: Histologic findings are not echoed in the visible effect in the epidermis after skin rejuvenation. SUBJECTS AND METHODS: Ten women (Group A) received five treatment sessions with a 595-nm pulsed dye laser immediately followed by a 1450-nm diode laser. Two other demographically similar groups of 10 patients each, Groups B and C, were treated with the 595-nm pulsed dye laser or the 1450-nm diode laser alone, respectively. RESULTS: Good dermal collagen remodeling was observed in Group A. Overall better and faster results were seen in Group A. The 6-month clinical outcome was best in Group A followed by Group C and Group B. CONCLUSIONS: Wavelengths of 595 plus 1450 nm for skin rejuvenation produced good results with much higher patient satisfaction than those obtained with the 595- or 1450-nm wavelengths alone.

An 810 nm diode laser in the treatment of small (< or = 1.0 mm) leg veins: a preliminary assessment.

A consistently effective treatment for small leg veins (< or = 1.0 mm) is still being sought. The efficacy of an 810 nm diode laser in vein removal was assessed in a preliminary study. Fifteen females, skin types I to III, vein diameters 0.5-1 mm, aged from 25 to 42 years, participated in the study. An 810 nm diode laser (90 W, 20 ms/pulse, 10 Hz rep rate, 4.0 mm hand piece) was applied along the target veins. Biopsies were taken from two patients before and after the first treatment session. No compression was applied post-treatment. Four weeks later, a second treatment was given. Results were assessed subjectively from the patients' satisfaction index (SI) and objectively from clinical photography done by an independent clinician, who also judged the venous morphology before and 4 weeks after the second session. All patients completed the trial. Pain was moderate to severe at the time of treatment and erythema which was mild, which was seen in all 15 patients; oedema occurred in 12 patients and blistering in only one. No scarring was noticed. The overall satisfaction indices at the 4- and 8-week assessments were 20.7% and 55.1%, respectively. No patient got worse. The objective evaluations at the 4- and 8-week assessments showed increasing improvement in all aspects examined. Pain at the time of treatment was a problem for all patients, so epidermal cooling should be added. Despite this, the 810 laser diode was an interesting and promising device for treatment of small leg veins, warranting further study in larger patient cohorts with a longer-term follow up.

Non-ablative facial skin photorejuvenation with an intense pulsed light system and adjunctive epidermal care.

Laser skin resurfacing is popular, but the appearance of the face during healing is unpleasant. Non-ablative photorejuvenation with intense pulsed light (IPL) has been reported as being successful but with varied results. In this study we sought the possibility of enhancing the clinical effects with adjunctive epidermal care. Twenty-five women aged from 32 to 68, skin types I-IV, with a variety of wrinkle types and other conditions associated with photoaged skin, were treated with IPL according to our parameters over six sessions coupled with an adjunctive pretreatment micropeel and applications of nutritive and antipigmenting creams. Macroscopic and histological assessments were performed. At weeks 4 and 8 fair to good satisfaction was noted in 17 and 19 patients, and poor satisfaction in 8 and 6 patients, respectively. The histology showed good dermal collagen remodelling in all cases, with a reduction in elastosis. The results of IPL photorejuvenation can be enhanced, as our trials showed. The good patient satisfaction obtained was clearly demonstrated in the histologies and evaluations throughout the study.

Ensayo clínico y de laboratorio de una crema de calendula en el Post Resurfacing Láser / Clinical laboratory trials of a calendula cream Following Laser Resurfacing

Con el fin de estudiar las características macro y microscópicas de la piel después del resurfacing láser, tratada con una crema cuyo principal componente es la caléndula, sé planteó un estudio experimental en la oreja del conejo. También, en pacientes, la fase del post resurfacing se siguió clínicamente, comparándola con áreas no tratadas con dicha crema. Para este estudio, las 2 orejas de un grupo de conejos fueron tratadas con igual técnica de resurfacing, empleando un aparato Derma-K, que combina los láser de Erbium:YAG y CO2. La programación empleada fue: Er:YAG 29 J/cm2, CO2 5W, 50 ms de duración del pulso y 50 por ciento de sobreposición de los disparos. Se utilizó una pieza de mano colimada con un haz de 3mm de diámetro y se realizó solo un pase láser.En cada animal, tras el resurfacing, se trató sólo una orejas con la crema de caléndula, utilizando la otra como control con vaselina estéril. En los días siguientes se identificaron las diferencias macroscópicas y se anotaron los cambios apreciados en las fotografías realizadas desde el microscopio. Comparativamente, la piel tratada con caléndula mostró mejor y más rápida recuperación, con evidentes diferencias en la red neo-vascular formada y también en la reepitelización controlada por biopsias. El estudio clínico se realizó en diez pacientes divididas en 2 grupos. En ambos se utilizaron idénticos parámetros de resurfacing y cuidados post-tratamiento que en la experimentación animal. Cinco pacientes fueron tratados con la crema de caléndula y los otros cinco con vaselina estéril. En la valoración de las diferencias de la piel, se observó que en los resurfacing tratados con vaselina la reepitelización se conseguía más tardíamente y la desaparición del eritema era más lenta (AU)