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1.
J Neurosurg ; 114(1): 189-95, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20509733

RESUMEN

Neuropathic facial pain can be a debilitating condition characterized by stabbing, burning, dysesthetic sensation. With a large range of causes and types, including deafferentation, postherpetic, atypical, and idiopathic, both medicine and neurosurgery have struggled to find effective treatments that address this broad spectrum of facial pain. The authors report the use of motor cortex stimulation to alleviate 3 distinct conditions associated with intractable facial pain: trigeminal deafferentation pain following rhizotomy, deafferentation pain secondary to meningioma, and postherpetic neuralgia. Functional MR imaging was used to localize facial areas on the precentral gyrus prior to surgery. All 3 patients experienced long-lasting complete or near-complete resolution of pain following electrode implantation. Efficacy in pain reduction was achieved through variation of stimulation settings over the course of treatment, and it was assessed using the visual analog scale and narrative report. Surgical complications included moderate postsurgical incisional pain, transient cerebral edema, and intraoperative seizure. The authors' results affirm the efficacy and broaden the application of motor cortex stimulation to several forms of intractable facial pain.


Asunto(s)
Terapia por Estimulación Eléctrica , Dolor Facial/terapia , Corteza Motora/fisiopatología , Dolor Intratable/terapia , Adulto , Anciano de 80 o más Años , Dolor Facial/etiología , Femenino , Herpes Zóster Ótico/complicaciones , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasias Meníngeas/complicaciones , Neoplasias Meníngeas/cirugía , Meningioma/complicaciones , Meningioma/cirugía , Persona de Mediana Edad , Corteza Motora/patología , Disinergia Cerebelosa Mioclónica , Dolor Intratable/etiología , Resultado del Tratamiento
2.
Neurol Clin ; 28(4): 979-1004, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20816274

RESUMEN

Entrapment neuropathies can be common conditions with the potential to cause significant disability. Correct diagnosis is essential for proper management. This article is a review of recent developments related to diagnosis and treatment of various common and uncommon nerve entrapment disorders. When combined with classical peripheral nerve examination techniques, innovations in imaging modalities have led to more reliable diagnoses. Moreover, innovations in conservative and surgical techniques have been controversial as to their effects on patient outcome, but randomized controlled trials have provided important information regarding common operative techniques. Treatment strategies for painful peripheral neuropathies are also reviewed.


Asunto(s)
Síndromes de Compresión Nerviosa/diagnóstico , Síndromes de Compresión Nerviosa/terapia , Nervios Periféricos/fisiopatología , Terapia por Estimulación Eléctrica , Humanos , Síndromes de Compresión Nerviosa/fisiopatología
3.
Neurosurgery ; 65(5): E997; discussion E997, 2009 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19834392

RESUMEN

OBJECTIVE: Chronic paroxysmal hemicrania (CPH) is a rare, unilateral primary headache syndrome. Recent studies suggest hypothalamic dysfunction as the likely cause of CPH. Therapeutic response to deep brain stimulation of the hypothalamus has been observed in the treatment of related trigeminal autonomic cephalgias. We explored the therapeutic effectiveness of posterior hypothalamic stimulation for the treatment of CPH in a patient intolerant of medical management. CLINICAL PRESENTATION: A 43-year-old woman with CPH reported acute onset of lancinating, unilateral headache pain focused about the right orbit. These debilitating headaches were accompanied by ipsilateral nasal congestion, conjunctival injection, tearing, and ptosis lasting minutes before resolving spontaneously. The patient exhausted attempts at medical management. TECHNIQUE: A deep brain stimulator microelectrode was placed under stereotactic guidance. The posterior hypothalamic target was 3 mm posterior, 5 mm inferior, and 2 mm ipsilateral to the midcommissural point. The electrode was connected to a standard pulse generator and set to final amplitude of 1.5 V, a pulse width of 60 microseconds, and a frequency of 185 Hz. CONCLUSION: The patient's headache symptoms were durably alleviated with intraoperative activation. No complications were observed. This preliminary success suggests a role for posterior hypothalamic stimulation as a safe and effective treatment in patients with medically refractory CPH. As a therapeutic incremental innovation, this off-label use of technology for symptomatic therapy contributes to results of studies that support a central pathophysiological role for hypothalamic dysfunction in headaches classified among the trigeminal autonomic cephalgias.


Asunto(s)
Estimulación Encefálica Profunda , Hipotálamo/fisiopatología , Hemicránea Paroxística/terapia , Adulto , Femenino , Humanos , Hemicránea Paroxística/fisiopatología
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