Development and current use of local antibiotic carriers in spondylodiscitis : Pilot study on reduction of duration of systemic treatment.

BACKGROUND: The current study situation regarding the duration of systemic antibiotic treatment for spondylodiscitis is inhomogeneous and varies between 4-12 weeks. Due to the many undesirable side effects the aim is to achieve complete healing without recurrence or hematogenous scatter within the shortest possible period of time. The present pilot study investigated whether the additional application of a local antibiotic carrier to the surgically treated intervertebral disc space can contribute to a further reduction of treatment duration. MATERIAL AND METHODS: In the pilot study 20 patients with acute spondylodiscitis and indications for surgical intervention were included. Surgical treatment was carried out by dorsal instrumentation, radical debridement of the site of infection, and cage interposition in the affected disc space. The remaining disc space was filled with homologous cancellous bone and antibiotic-loaded calcium sulfate hydroxyapatite pellets. A classification into a long-term and a short-term antibiotic group was performed. Both groups initially received a 10-day parenteral antibiotic administration. This was followed by oral antibiotics for 2 or 12 weeks, depending on the group. During the 12-month follow-up inflammation parameters, the local infection situation as well as the bony fusion and antibiotic tolerance were regularly checked. RESULTS: The average age of the patients was 66.7 ± 11.2 years. Intraoperative detection of pathogens was successful in 65%. In 60% the antibiotic carrier was loaded with gentamicin, in 40% with vancomycin. At follow-up, all patients except one in the short-term antibiotic group had inflammation parameters within the normal range after 3 months. In the long-term antibiosis group, two patients still showed elevated infection values after 3 months, otherwise the values were within the normal range. After 12 months a complete cure of the infection was achieved in all patients. Antibiotic treatment intolerance occurred in 10% of the short-term antibiotic group and in 50% of the long-term group. CONCLUSION: The results of the present pilot study show that with the additional use of absorbable local antibiotic carriers in the surgical treatment of bacterial spondylodiscitis it is possible to shorten the duration of systemic antibiotic treatment to 3 weeks. This can reduce the side effects and incompatibility of treatment and still achieve similar healing results.

[Pre- and postoperative fast-track treatment concepts in spinal surgery : patient information and patient cooperation]. / Prä- und postoperative Fast-track-Behandlungskonzepte in der Wirbelsäulenchirurgie : Patienteninformation und Patientenkooperation.

BACKGROUND: Evidence-based procedures and pathways to reduce peri- and postoperative complications, while simultaneously achieving a high satisfaction rate of patients and lower costs are important goals in the treatment of orthopedic patients. PURPOSE: This article describes the key factors to improve treatment of patients with indications for stabilization of one or two segments in the field of degenerative lumbar spine pathologies. A fast-track concept was developed to optimize the pathway of treatment, while increasing patient satisfaction and shortening the hospital stay. In the present patient cohort, significantly greater patient satisfaction and significantly shorter hospital stays were achieved. RESULTS: The hospital stay was reduced from 10.9 to 6.2 days after introduction of a multimodal patient school that was held 10 days prior to admission, with mobilization on the day of surgery with a strictly followed treatment plan supervised by therapists and taking into account the patient's own assessment, as well an early plan for discharge based on fixed established criteria. This concept is a very successful tool to achieve high quality standard of treatment paired with a reduction of hospital stay.

[Diagnostics and minimally invasive therapy for chronic low back pain]. / Diagnostik und minimal-invasive Therapie bei chronischen Lumbalgien.

Chronic low back pain is one of the most frequent causes for seeking medical help in Germany. Many factors play a causal role in its pathogenesis. This is where the dilemma resides in narrowing down the diagnosis and deciding on subsequent therapeutic intervention. There is overall agreement on the concept of when it is expedient to initiate further diagnostic measures. With the exception of clear pathomorphological findings and the presence of cardinal symptoms or warning signs, so-called "red flags", primary back pain should not be subjected to any specific diagnostic tests and therapy during the first 3 months. We present well-established techniques for blockade, discography, and minimally invasive treatment options such as cryotherapy, procedures for thermal ablation, and intradiscal electrotherapy. Vertebroplasty, currently a frequently applied method, is also included in the discussion of minimally invasive treatment for chronic low back pain.