RESUMEN
This study was performed to evaluate the effects of selenium supplementation on gene expression related to insulin and lipid metabolism, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM). The current randomized, double-blind, placebo-controlled clinical trial was conducted in 36 patients with GDM. Participants were randomly divided into two groups to intake either 200 µg/day selenium supplements as selenium yeast or placebo (n = 18 each group) for 6 weeks. Selenium supplementation upregulated peroxisome proliferator-activated receptor gamma (P = 0.03) and glucose transporter 1 (GLUT-1) (P = 0.01) in lymphocytes of subjects with GDM compared with the placebo. Selenium supplementation did not affect gene expression of low-density lipoprotein receptor (LDLR) and lipoprotein(a) [Lp(a)]. Supplementation with selenium had a significant decrease in incidence of newborns' hyperbilirubinemia (5.6% vs. 33.3%, P = 0.03) and newborns' hospitalization (5.6% vs. 33.3%, P = 0.03) compared with the placebo. Overall, we found that selenium supplementation for 6 weeks among patients with GDM significantly increased PPAR-γ and GLUT-1 expression, but did not affect gene expression of LDLR and LP(a). It also reduced incidence of newborns' hyperbilirubinemia and newborns' hospitalization. Clinical trial registration number: http://www.irct.ir: IRCT20170513033941N35.
Asunto(s)
Diabetes Gestacional/tratamiento farmacológico , Insulina/genética , Metabolismo de los Lípidos/genética , Resultado del Embarazo/genética , Selenio/farmacología , Diabetes Gestacional/genética , Diabetes Gestacional/metabolismo , Suplementos Dietéticos , Método Doble Ciego , Femenino , Expresión Génica/efectos de los fármacos , Hospitalización , Humanos , Hiperbilirrubinemia/tratamiento farmacológico , Hiperbilirrubinemia/genética , Hiperbilirrubinemia/metabolismo , Recién Nacido , Insulina/metabolismo , Embarazo , Selenio/administración & dosificaciónRESUMEN
BACKGROUND: Numerous studies show a growing trend in cesarean section rates throughout the world, including Iran. However, existing evidence in our country is scant and previous reports are restricted to short time periods. The aim of the current study is to measure the trend in cesarean sections (CS) rates over the past 30 years in a referral hospital in Tehran. METHODS: We routinely collected data on the demographic characteristics of all women who gave birth in the hospital during the study period. The mode of delivery and the personnel in charge of delivery has likewise been recorded for each birth during the study period. The data were extracted from medical records and entered into a structured checklist. RESULTS: The rate of CS out of all deliveries increased from 14.3% in 1979 to 22.7% in 1989, 52.5% in 1999, and 85.3% in 2009 (P < 0.001). The most common reason for CS was a repeated section. The percentage of vaginal deliveries performed by midwives has not changed significantly and the number of both midwives and obstetricians per 1000 births has increased, from 2.8 to 15.4 midwives per 1000 births and from 5.5 to 23.0 obstetricians per 1000 births. CONCLUSION: Immediate strategies should be adopted to prevent the rising trend and increasing number of unnecessary CS in Iran.