RESUMEN
Cancer is one of the major challenges fronting the biomedical basic researches in our time. The study and development of effective therapeutic strategies for cancer therapy are vital. Among the many probable core constituents of nanoparticles, magnetite-based nanoparticles have been widely studied for cancer therapy owing to their inherent magnetic features, multifunctional design, biodegradable and biocompatible properties. Magnetic nanoparticles have been also designed for utilizing as contrast enhancer agents for magnetic resonance imaging, drug delivery systems, and most recently as a therapeutic element in inducing cellular death in tumor ablation therapies. This review aimed to provide an overview of the various applications of magnetic nanoparticles and recent achievements in developing these advanced materials for cancer therapy.
Asunto(s)
Antineoplásicos/administración & dosificación , Medios de Contraste , Portadores de Fármacos , Magnetoterapia , Nanopartículas Magnéticas de Óxido de Hierro , Imagen Molecular , Nanomedicina , Neoplasias/diagnóstico por imagen , Neoplasias/terapia , Animales , Antineoplásicos/efectos adversos , Medios de Contraste/efectos adversos , Portadores de Fármacos/efectos adversos , Humanos , Magnetoterapia/efectos adversos , Nanopartículas Magnéticas de Óxido de Hierro/efectos adversosRESUMEN
Escalating antibiotic resistance is now a serious menace to global public health. It may be led to the emergence of "postantibiotic age" in which most of infections are untreatable. At present, there is an essential need to explore novel therapeutic strategies as a strong and sustainable pipeline to combat antibiotic-resistant infections. This review focuses on recent advances in this area including therapeutic antibodies, antimicrobial peptides, vaccines, gene therapy, genome editing, and phage therapy for tackling drug-resistant infections.