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Bioorg Med Chem Lett
; 13(19): 3217-21, 2003 Oct 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12951096
RESUMEN
The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-alpha synthesis and displayed good specificity in suppressing cytokine expression.