RESUMEN
Rosacea is a chronic inflammatory disorder of the central face with multiple overlapping presentations. Recent advancements are reshaping our understanding of rosacea from both a pathophysiologic perspective and clinical approach to therapy, introducing novel agents that have improved patient outcomes and reduced morbidity. In this article, we aim to outline the advancements in understanding, diagnosing, and managing rosacea and to familiarize physicians with the literature, thereby allowing us to better practice safe and effective medicine.
Asunto(s)
Salud Holística , Rosácea , Humanos , Rosácea/diagnóstico , Rosácea/etiología , Rosácea/terapiaRESUMEN
Therapeutic actives for acne have changed little in the last decade. Recognition that acne is an inflammatory condition, not an infectious one, has led to a call for reduction in antibiotic use. This has culminated in a re-evaluation of highly efficacious combination topical therapy and improved vehicle technology. Laser and light modalities, although not sufficiently studied for first-line use, show promise for the future. The role that diet plays in the initiation and continuation of acne is unclear but remains one of our patients' most frequently asked questions.
Asunto(s)
Acné Vulgar/terapia , Antibacterianos/uso terapéutico , Fármacos Dermatológicos/uso terapéutico , Dietoterapia , Terapia por Luz de Baja Intensidad , Fototerapia , Acné Vulgar/inmunología , Administración Cutánea , Administración Oral , Terapia Combinada , Dapsona/uso terapéutico , Ácidos Dicarboxílicos/uso terapéutico , Quimioterapia Combinada , Humanos , Inflamación , Retinoides/uso terapéuticoRESUMEN
Laboratory monitoring for patients on isotretinoin should include creatinine kinase in athletic males and the more liver-specific gamma glutamyltransferase. There is mounting evidence that acne pathophysiology includes a barrier defect and subsequent microbiome disruption. Avoidance of acne scars with early and aggressive treatment is a more efficient and cost-effective option than subsequent treatment. Laser and light treatments for acne and acne scars are plentiful but poorly supported by evidence-based medicine. The acne pipeline is rich with new chemical entities, new formulations, and combinations of older agents. The gold standard for acne therapy may be changing its face.
Asunto(s)
Acné Vulgar/complicaciones , Acné Vulgar/terapia , Cicatriz/epidemiología , Fármacos Dermatológicos/administración & dosificación , Isotretinoína/administración & dosificación , Acné Vulgar/microbiología , Antibacterianos/uso terapéutico , Cicatriz/etiología , Cicatriz/terapia , Creatina Quinasa/sangre , Cara , Humanos , Tratamiento de Luz Pulsada Intensa , Pruebas de Función Hepática , Microbiota , Fotoquimioterapia , Prebióticos , Probióticos/uso terapéutico , Retinoides/uso terapéutico , Sebo/efectos de los fármacos , Sebo/metabolismo , Piel/microbiologíaRESUMEN
The effective and safe treatment of acne vulgaris often is affected by individual patient characteristics, including skin color and cultural background. Skin of color is especially prone to hyperpigmentation, both from lesions and from irritating therapy. Clinicians also should be aware of cultural attitudes and folk remedies that may adversely affect dermatologic conditions such as acne.