RESUMEN
The root bark of Pongamia pinnata Pierre (syn P. glabra Vent.) has afforded a new biflavonyloxymethane, pongabiflavone, along with a known furanoflavone, 3-methoxy-(7, 8, 2", 3") furanoflavone. The structure of this new compound was elucidated from extensive spectral studies, including 2D-NMR spectroscopic experiments. The antioxidant, radical quenching activity- superoxide and nitric oxide quenching activities of both pongabiflavone and previously isolated karanjabiflavone have been evaluated which can be a key to cure Psoriasis.
Asunto(s)
Biflavonoides/aislamiento & purificación , Depuradores de Radicales Libres/aislamiento & purificación , Millettia/química , Pongamia/química , Biflavonoides/química , Estructura MolecularRESUMEN
The root bark of Pongamia pinnata Pierre Syn Pongamia glabra (Family: Fabaceae) has afforded a new biflavonyloxymethane, karanjabiflavone, along with a known furanoflavone, pongapin. The structure of this new biflavonyloxymethane was elucidated from extensive spectral studies including 2D-NMR experiments. Both of these compounds possess antioxidant activity.
Asunto(s)
Antioxidantes/aislamiento & purificación , Flavonas/aislamiento & purificación , Millettia/química , Antioxidantes/química , Benzopiranos/aislamiento & purificación , Flavonas/química , Espectroscopía de Resonancia Magnética , Corteza de la Planta/químicaRESUMEN
The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their (1)H-, (13)C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE(2)-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wistar rats.
Asunto(s)
Antidiarreicos/uso terapéutico , Diarrea/tratamiento farmacológico , Alcaloides Indólicos/uso terapéutico , Fitoterapia , Rutaceae/química , Animales , Antidiarreicos/aislamiento & purificación , Antidiarreicos/farmacología , Aceite de Ricino , Catárticos , Diarrea/inducido químicamente , Dinoprostona , Difenoxilato , Evaluación Preclínica de Medicamentos , Femenino , Motilidad Gastrointestinal/efectos de los fármacos , Alcaloides Indólicos/aislamiento & purificación , Alcaloides Indólicos/farmacología , Masculino , Estructura Molecular , Oxitócicos , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico , Ratas , Ratas Wistar , Semillas/químicaRESUMEN
The gum resin of Ferula assafoetida Linn. afforded one new sesquiterpene, asimafoetida 1 and three known sesquiterpenoid coumarins. The structure has been established from extensive 2D NMR spectral studies as 7'-[7-(1R,3S)-5-Hydroxy-6,6-dimethyl-2-methylene-cyclohexyl]-9-methyl-9-pentenyl]oxy]-2H-1-benzopyran-2-one. The other three known compounds are ferulic acid, farnesiferol A and farnesiferol C.
Asunto(s)
Cumarinas/análisis , Ferula/química , Sesquiterpenos/análisis , Espectroscopía de Resonancia Magnética/métodos , Plantas Medicinales/químicaRESUMEN
The root bark of Pongamia pinnata Pierre [syn P. glabra (family: Fabaceae)] afforded a new chalcone (karanjapin) and two known flavonoids, a pyranoflavonoid (karanjachromene) and a furanoflavonoid (karanjin) The structure of karanjapin has been established from extensive 2D NMR spectral studies as beta,2'-dihydroxy-a,4'-dimethoxy-3,4-methylenedioxychalcone. Karanjapin and karanjachromene were found to possess significant antioxidant activity. This may play an important role in the pathogenesis of several diseases.
Asunto(s)
Antioxidantes/química , Chalconas/química , Millettia/química , Estructura Molecular , Corteza de la Planta/química , Raíces de Plantas/químicaRESUMEN
Phytochemical investigation of the gum resin of Ferula assafoetida resulted in the isolation and characterization of a new sesquiterpenoid coumarin, Saradaferin (1) named as [Decahydro-(3-alpha-hydroxy-4,4,10-trimethyl-8-methylene-9-naphthenyl)-alpha-hydroxymethyl] ether of umbelliferone.