In-vitro cytotoxicity of nickel oxide nanoparticles against L-6 cell-lines: MMP, MTT and ROS studies.

In the present work we synthesize nickel oxide nanoparticles (NiO NPs) using Rhododendron arboretum (flower) (RNi), Tinospora cordifolia (stems) (GNi), Corylus jacquemontii (seeds) (CNi), and Nardostachys jatamansi (roots) (NNi) extracts by co-precipitation method. The synthesized NiO NPs were characterized in detail in terms of their morphological, crystalline nature, structural and antiproliferative activity against rat skeletal myoblast (L-6) cell lines. Morphological studies confirmed the formation of nanoparticles, while the structural and compositional characterization revealed the well-crystallinity and high purity of the synthesized nanoparticles. For biological applications and cytotoxicity examinations of the synthesized NPs, the rat skeletal myoblast (L-6) cell lines were subjected to study. By detailed cytotoxic investigations, it was observed that among the four kinds of NiO NPs prepared through different plant extracts, the Tinospora cordifolia (stems) showed strong antiproliferative activity against rat skeletal myoblast (L-6) cell lines and the calculated IC50 was 1.671 mg/mL. The observed antiproliferative activity towards different NiO NPs were in the order of GNi > NNi > RNi > CNi. The present studies demonstrate that simply synthesized NiO can efficiently be used as antiproliferative agents.

Sustainable agronomic response of carbon quantum dots on Allium sativum: Translocation, physiological responses and alternations in chromosomal aberrations.

The revolutionary growth in the usage of carbon quantum dots (CQDs) in different areas have ultimately directed their discharge in the environment and further augmented the exposure of agricultural crops to these released particles. Therefore, the aim of current study is to evaluate the uptake, translocation and phytotoxicity of blue emissive CQDs on Allium sativum plant. The genotoxicity and cytotoxicity assessment of CQDs towards Allium sativum roots was estimated as function of three different concentrations. Considering the role of CQDs in promoting seed germination at 50 ppm concentration, a greenhouse experiment was performed to evaluate their effect on plant growth. Systematic investigations have shown the translocation of CQDs and their physiological response in terms of increased shoot length wherein P-CQDs exhibited more accumulation into Allium sativum parts. Our investigations unfold the opportunity to utilize Aegle marmelos fruit derived CQDs as a growth regulator in variety of other food plants.