Asunto(s)
Proteínas de Transporte de Catión/genética , Terapia por Quelación/métodos , Enfermedades Metabólicas/genética , Mutación/genética , Trastornos Parkinsonianos/tratamiento farmacológico , Trastornos Parkinsonianos/genética , Femenino , Humanos , Estudios Longitudinales , Enfermedades Metabólicas/complicaciones , Persona de Mediana Edad , Trastornos Parkinsonianos/complicaciones , Transportador 8 de ZincRESUMEN
The authors describe a case of early onset ataxia with cerebellar atrophy and vitamin E deficiency, treated with alpha-tocopherol supplementation and physically rehabilitated by postural biofeedback. Clinical assessments, serum vitamin E levels and postural evaluation by means of a stabilometric platform continued for about 2 years and significant clinical improvement was recorded. Our study confirms that combined physical therapy and vitamin E supplementation may result in improvement of cerebellar function. Motor improvement is directly related to vitamin E serum levels, providing further confirmation that normal vitamin E levels are crucial for proper brain functions.
Asunto(s)
Enfermedades Cerebelosas/diagnóstico , Enfermedades Cerebelosas/etiología , Cerebelo/patología , Deficiencia de Vitamina E/complicaciones , Adolescente , Atrofia , Biorretroalimentación Psicológica , Femenino , Humanos , Imagen por Resonancia Magnética , Modalidades de Fisioterapia , Postura/fisiología , Vitamina E/uso terapéutico , Deficiencia de Vitamina E/fisiopatología , Deficiencia de Vitamina E/rehabilitaciónRESUMEN
During the recent years, numerous reports have focused the attention on the role of vitamin E as a trophic factor in normal function of the nervous system and in protection against aging or other age related pathologies as tumors, Parkinson's disease and several spino-cerebellar syndromes. We have previously reported cases with severe neurological diseases, including peripheral and central pathology due to abnormality of primary symptoms after vitamin E supplementation. Here we report the results of our studies on the changes of serum concentration of vitamin E during development and aging. vitamin E has been measured in the serum of 479 normal subjects from the birth to the age of 106 years, groupped as follows: below 20; 20-40; 40-60; 60-80; 80-100 and above 100 years. The results, show a linear increase of serum vitamin E values (18 mumole/l in the youngest group to 33.2 mumole/l in the centenarians). The data may be related to higher vitamin E intake during aging or to higher adsorption, or to minor catabolism and utilization. In any case, the highest vitamin E availability during aging has been shown and its role in protection against death is discussed.
RESUMEN
We report the clinical, neurophysiological (comprehending electromyography, nerve conduction velocities, and multimodal evoked potentials), histological study of the nerve and muscle and the effect of vitamin E supplement in a 32-year-old case with chronic vitamin E deficiency subsequent to acquired intestinal malabsorption. An early diagnosis for an early treatment is essential in preventing severe neurological deterioration.