Asunto(s)
Terapia por Estimulación Eléctrica/métodos , Nervio Óptico/fisiopatología , Trastornos de la Visión/fisiopatología , Visión Ocular/fisiología , Adolescente , Adulto , Ceguera/fisiopatología , Ceguera/terapia , Enfermedad Crónica , Ensayos Clínicos como Asunto , Electrodos Implantados , Electroencefalografía , Potenciales Evocados Visuales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estimulación Luminosa , Trastornos de la Visión/terapia , Agudeza VisualAsunto(s)
Terapia por Estimulación Eléctrica , Atrofia Óptica/terapia , Adolescente , Adulto , Electrodos Implantados , Electrodiagnóstico , Potenciales Evocados Visuales , Femenino , Guaniltiourea/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Atrofia Óptica/diagnóstico , Atrofia Óptica/etiología , Piracetam/uso terapéutico , Neoplasias Hipofisarias/complicaciones , Agudeza VisualRESUMEN
Comparative analysis of the CSF and blood protein-peptide composition in Parkinsonian patients performed with the aid of indwelled electrodes prior to and after therapeutic electrical stimulation (TES) of the brain subcortical structures, revealed a therapeutic effect in the form of reduced muscular rigidity and a mental activation with a positive emotional response. After the TES the protein content in the biological fluids tended to become normalized and the the range of low-molecular protein-peptide fractions changed. A high-performance liquid chromatography, bidimensional electrophoresis and thin-layer chromatography revealed about 5-6 factors of peptide nature with the molecular mass less than 5000 daltons in the CSF and blood after the TES. These factors were shown to exert a biological effect upon muscle preparation of the leech.
Asunto(s)
Proteínas Sanguíneas/análisis , Proteínas del Líquido Cefalorraquídeo/análisis , Terapia por Estimulación Eléctrica , Enfermedad de Parkinson/terapia , Globo Pálido , Humanos , Masculino , Enfermedad de Parkinson/sangre , Enfermedad de Parkinson/líquido cefalorraquídeo , Péptidos/sangre , Péptidos/líquido cefalorraquídeo , Núcleos TalámicosRESUMEN
The author substantiates the necessity of searching for new means producing a therapeutic effect on the brain of epileptic patients that would be similar, in principle, to the brain's own protective mechanisms. This can be done, in the author's opinion, on the basis of studying the most probable bioelectric equivalents of the protective mechanisms. The author suggests a new method for suppressing the epileptogenic focus. This suppression, close to the physiological one, is effected by applying a weak sinusoidal current to the focus via intracerebrally implanted electrodes. Data on the suppression of the epileptiform activity within the zone of the current application, as well as data confirming the local character of the current action are presented. The place of the new method in the system of complex therapy, particularly of epilepsy, is determined with consideration of the role of the stable pathological state. Probable neurophysiological mechanisms of the sinusoidal current action on the epileptogenic focus are discussed.