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1.
Epidemiology ; 28(5): 675-684, 2017 09.
Artículo en Inglés | MEDLINE | ID: mdl-28520643

RESUMEN

BACKGROUND: Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles-particularly through inhalation-occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers. METHODS: We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and plutonium workers. Cases were workers who died from lung cancer; one to three controls were matched to each. Lung doses from alpha-emitters were assessed using bioassay data. We estimated excess odds ratio (OR) of lung cancer per gray (Gy) of lung dose. RESULTS: The study comprised 553 cases and 1,333 controls. Median positive total alpha lung dose was 2.42 mGy (mean: 8.13 mGy; maximum: 316 mGy); for plutonium the median was 1.27 mGy and for uranium 2.17 mGy. Excess OR/Gy (90% confidence interval)-adjusted for external radiation, socioeconomic status, and smoking-was 11 (2.6, 24) for total alpha dose, 50 (17, 106) for plutonium, and 5.3 (-1.9, 18) for uranium. CONCLUSIONS: We found strong evidence for associations between low doses from alpha-emitters and lung cancer risk. The excess OR/Gy was greater for plutonium than uranium, though confidence intervals overlap. Risk estimates were similar to those estimated previously in plutonium workers, and in uranium miners exposed to radon and its progeny. Expressed as risk/equivalent dose in sieverts (Sv), our estimates are somewhat larger than but consistent with those for atomic bomb survivors.See video abstract at, http://links.lww.com/EDE/B232.


Asunto(s)
Partículas alfa/efectos adversos , Industria Procesadora y de Extracción , Neoplasias Pulmonares/mortalidad , Exposición Profesional/efectos adversos , Plutonio/efectos adversos , Uranio/efectos adversos , Anciano , Bélgica/epidemiología , Estudios de Casos y Controles , Industria Procesadora y de Extracción/estadística & datos numéricos , Femenino , Francia/epidemiología , Humanos , Neoplasias Pulmonares/etiología , Masculino , Persona de Mediana Edad , Exposición Profesional/estadística & datos numéricos , Radiometría , Factores de Riesgo , Reino Unido/epidemiología
2.
Int J Radiat Biol ; 90(11): 1080-7, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25066877

RESUMEN

PURPOSE: Epidemiological studies of the French uranium miners and the plutonium workers at the Mayak nuclear facility have provided excess relative risk (ERR) estimates per unit absorbed lung dose from alpha radiation. The aim of this paper was to review these two studies and to derive values of the relative biological effectiveness (RBE) of alpha particles for the induction of lung cancer. MATERIALS AND METHODS: We examined and compared the dosimetry assumptions and methodology used in the epidemiological studies of uranium miners and the plutonium workers. Values of RBE were obtained by comparing risk coefficients including comparison of lifetime risks for a given population. To do this, preliminary calculations of lifetime risks following inhalation of plutonium were carried out. RESULTS AND CONCLUSIONS: Published values of risk per unit dose following inhalation of radon progeny and plutonium were in agreement despite the very different dose distributions within the lungs and the different ways the doses were calculated. Values of RBE around 10-20 were obtained by comparing ERR values, but with wide uncertainty ranges. Comparing lifetime risks gave similar values (10, 19 and 21). This supports the use of a radiation weighting factor of 20 for alpha particles for radiation protection purposes.


Asunto(s)
Neoplasias Pulmonares/etiología , Neoplasias Inducidas por Radiación/etiología , Plutonio/efectos adversos , Radón/efectos adversos , Partículas alfa , Animales , Perros , Humanos , Persona de Mediana Edad , Minería , Neoplasias Inducidas por Radiación/epidemiología , Exposición Profesional , Dosis de Radiación , Radiometría , Ratas , Efectividad Biológica Relativa , Medición de Riesgo , Uranio/efectos adversos
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