1.
Bioorg Med Chem Lett
; 23(11): 3354-7, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23639543
RESUMEN
Ribonucleoside phosphonate analogues containing 2'-α-fluoro modifications were synthesized and their potency evaluated against HCV RNA polymerase. The diphosphophosphonate (triphosphate equivalent) adenine and cytidine analogues displayed potent inhibition of the HCV polymerase in the range of 1.9-2.1 µM, but only modest cell-based activity in the HCV replicon. Pro-drugs of the parent nucleoside phosphonates improved the cell-based activity.