1.
Bioorg Med Chem Lett
; 25(17): 3711-5, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26099532
RESUMEN
The design and synthesis of new non-symmetrical NS5A inhibitors with sulfur containing amino acids is reported along with their ability to block HCV replication in an HCV 1b replicon system. These compounds display EC50 values in the picomolar range with a large therapeutic index (>10(6)). Moreover, cellular pharmacology studies show that our preferred compounds intracellularly deliver three potent NS5A inhibitors.