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1.
J Vet Cardiol ; 51: 172-178, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38141434

RESUMEN

An 11-year-old spayed female domestic shorthaired cat was diagnosed with severe dilated cardiomyopathy (DCM) and congestive heart failure. The cat had been eating cat foods that were high in pulses (e.g. peas, lentils, chickpeas). Neither plasma nor whole blood taurine concentrations were deficient. Primary treatment included furosemide, pimobendan, and clopidogrel, and changing to diets that did not contain pulses (a taurine supplements was not administered). The cat's clinical signs improved, high-sensitivity cardiac troponin I concentrations decreased, and echocardiographic measurements stayed relatively stable for over one year after initiating cardiac medications and changing the diet. Ultimately, the cat was euthanized for worsening congestive heart failure 374 days after the diagnosis of DCM. Infectious disease testing during the time of clinical surveillance was negative. Routine histopathology of the heart was unremarkable, but electron microscopy of the left ventricle showed large numbers of mitochondria of variable size and structure. A moderate number of lamellar bodies and autophagic vacuoles also were noted. This case report illustrates an unusual case of a cat with DCM unrelated to taurine deficiency. The relative roles of diet change, cardiac medications, and a dedicated owner are unclear, but this cat's relatively long survival time is similar to that seen after diet change in dogs and cats with DCM eating high-pulse diets.


Asunto(s)
Cardiomiopatía Dilatada , Enfermedades de los Gatos , Enfermedades de los Perros , Insuficiencia Cardíaca , Gatos , Femenino , Animales , Perros , Cardiomiopatía Dilatada/veterinaria , Cardiomiopatía Dilatada/diagnóstico , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/tratamiento farmacológico , Enfermedades de los Perros/diagnóstico , Dieta/veterinaria , Taurina/uso terapéutico , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/veterinaria
3.
Antimicrob Agents Chemother ; 41(11): 2448-55, 1997 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-9371348

RESUMEN

Enrofloxacin and doxycycline are antimicrobial agents used to treat bacterial diseases of cats. In vitro susceptibility data indicate that either drug should be effective against Bartonella species. In vivo efficacies of these drugs for eradication of chronic Bartonella henselae or Bartonella clarridgeiae infections were examined in 18 experimentally infected cats and 25 naturally exposed cats treated with enrofloxacin (22.7 mg given orally [PO] every 12 h [q12h] [14 days, n = 10; 28 days, n = 13]) or with doxycycline (25 mg PO q12h [14 days, n = 9; 28 days, n = 8]) or not treated (n = 3). Plasma drug concentrations were determined in experimental cats by high-performance liquid chromatography. Only 23 of 43 cats enrolled ultimately met inclusion criteria. Bacteremia was eliminated for 12 to 25 weeks posttreatment in four of seven cats receiving 14 days of enrofloxacin, five of seven cats receiving 28 days of enrofloxacin, one of six cats receiving 14 days of doxycycline, and one of two cats receiving 28 days of doxycycline. Defining a negative result by blood culture as treatment success may be erroneous; these results may reflect the insensitivity of blood culture or the relapsing nature of Bartonella bacteremia. Our results suggest that MICs obtained with axenic media do not predict antimicrobial activity against intracellular Bartonella, that a long treatment course is required to eliminate infection, and that duration of therapy correlates with pretreatment bacterial load. Given current concern about the development of antimicrobial resistance, we would reserve recommendation for treatment to cats owned by an immunocompromised individual or as an alternative to euthanasia of a pet.


Asunto(s)
Antibacterianos/uso terapéutico , Antiinfecciosos/uso terapéutico , Infecciones por Bartonella/veterinaria , Bartonella henselae , Enfermedades de los Gatos/tratamiento farmacológico , Doxiciclina/uso terapéutico , Fluoroquinolonas , Quinolonas/uso terapéutico , Administración Oral , Animales , Antiinfecciosos/sangre , Infecciones por Bartonella/tratamiento farmacológico , Bartonella henselae/efectos de los fármacos , Gatos , Cromatografía Líquida de Alta Presión , Doxiciclina/sangre , Evaluación Preclínica de Medicamentos , Enrofloxacina , Pruebas de Sensibilidad Microbiana , Quinolonas/sangre
4.
J Vet Intern Med ; 8(5): 349-54, 1994.
Artículo en Inglés | MEDLINE | ID: mdl-7837112

RESUMEN

An 11-year-old castrated male mixed breed dog was referred for evaluation of muscle twitching, polyuria, polydipsia, anorexia, and periocular alopecia. Primary hypoparathyroidism was diagnosed by documenting decreased serum concentrations of parathyroid hormone and ionized calcium. Neurological, gastrointestinal, and dermatological signs resolved after calcium repletion. Initially, 1,25-dihydroxycholecalciferol PO was required to correct the hypocalcemia. Dihydrotachysterol, in combination with oral calcium supplementation, was used for long-term maintenance of normal serum calcium concentration. Aminoaciduria, glucosuria, and hyperchloremic metabolic acidosis were consistent with a diagnosis of Fanconi's syndrome. This diagnosis was further supported by the presence of hypokalemia and increased urinary fractional excretion of sodium, potassium, calcium, phosphorus, and magnesium. Renal tubular dysfunction resolved after oral supplementation with calcium and vitamin D3. Fanconi's syndrome in this dog may have been caused by decreased serum concentration of 1,25-dihydroxycholecalciferol, which was secondary to decreased parathyroid hormone production.


Asunto(s)
Enfermedades de los Perros , Síndrome de Fanconi/veterinaria , Hipoparatiroidismo/veterinaria , Animales , Análisis Químico de la Sangre/veterinaria , Calcitriol/sangre , Calcitriol/deficiencia , Calcitriol/uso terapéutico , Calcio/uso terapéutico , Dihidrotaquisterol/uso terapéutico , Enfermedades de los Perros/sangre , Enfermedades de los Perros/diagnóstico , Enfermedades de los Perros/etiología , Perros , Síndrome de Fanconi/sangre , Síndrome de Fanconi/diagnóstico , Síndrome de Fanconi/etiología , Hipoparatiroidismo/sangre , Hipoparatiroidismo/complicaciones , Hipoparatiroidismo/diagnóstico , Masculino , Hormona Paratiroidea/sangre , Hormona Paratiroidea/deficiencia , Desequilibrio Hidroelectrolítico/veterinaria
5.
Antimicrob Agents Chemother ; 35(11): 2375-81, 1991 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-1666498

RESUMEN

Dogs were experimentally inoculated with Rickettsia rickettsii to characterize the comparative efficacies of chloramphenicol, enrofloxacin, and tetracycline for the treatment of Rocky Mountain spotted fever (RMSF). All three antibiotics were equally effective in abrogating the clinical, hematologic, and vascular indicators of rickettsial infection. Antibiotic treatment for 24 h was sufficient to decrease the rickettsemia to levels below detection by Vero cell culture. Early treatment with all three antibiotics resulted in a similar decrease in antibody titer, but acute and convalescent serum samples taken at appropriate times would have still facilitated an accurate diagnosis of RMSF in all but one dog, which did not seroconvert. We conclude that chloramphenicol, enrofloxacin, and tetracycline are equally efficacious for treating experimental canine RMSF.


Asunto(s)
Antiinfecciosos/uso terapéutico , Cloranfenicol/uso terapéutico , Fluoroquinolonas , Quinolonas/uso terapéutico , Fiebre Maculosa de las Montañas Rocosas/tratamiento farmacológico , Tetraciclina/uso terapéutico , Animales , Anticuerpos Antibacterianos/análisis , Permeabilidad Capilar/fisiología , Perros , Enrofloxacina , Femenino , Técnica del Anticuerpo Fluorescente , Fiebre Maculosa de las Montañas Rocosas/microbiología , Fiebre Maculosa de las Montañas Rocosas/fisiopatología , Células Vero
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