RESUMEN
Clostridium difficile infection (CDI) has become more refractory to standard therapy. We describe 4 patients with severe refractory CDI who were successfully treated with tigecycline. Symptoms improved within 1 week. No relapses were observed. This favorable outcome suggests that tigecycline might be a useful alternative for treating severe refractory CDI.
Asunto(s)
Antibacterianos/uso terapéutico , Clostridioides difficile/aislamiento & purificación , Enterocolitis Seudomembranosa/tratamiento farmacológico , Minociclina/análogos & derivados , Adulto , Anciano de 80 o más Años , Terapias Complementarias/métodos , Enterocolitis Seudomembranosa/microbiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Minociclina/uso terapéutico , Tigeciclina , Resultado del TratamientoRESUMEN
Tendinopathies with and without tendon rupture are rare adverse events, occurring mainly following older fluoroquinolones, but recently also to an increasing extent following levofloxacin. We report the first case of tendinitis after treatment with moxifloxacin, and of recurrent tendinitis after treatment with 2 different fluoroquinolones. From these findings we conclude hitherto unexplained class effect of fluoroquinolones in respect of the development of tendinitis.
Asunto(s)
Antiinfecciosos/efectos adversos , Compuestos Aza/efectos adversos , Fluoroquinolonas/efectos adversos , Levofloxacino , Ofloxacino/efectos adversos , Quinolinas/efectos adversos , Tendinopatía/inducido químicamente , Tendón Calcáneo/diagnóstico por imagen , Anciano , Antiinfecciosos/uso terapéutico , Asma/tratamiento farmacológico , Compuestos Aza/uso terapéutico , Femenino , Fluoroquinolonas/uso terapéutico , Humanos , Moxifloxacino , Ofloxacino/uso terapéutico , Quinolinas/uso terapéutico , Recurrencia , UltrasonografíaRESUMEN
Hydrocarbon pneumonitis, known also as fire-eater pneumonia, always develops after aspiration of low-viscosity, volatile hydrocarbides. Despite the presence of clear-cut indicators for an infection, it is considered to be an acute pseudoinfectious lung disease. In this article, we report on a relatively rare clinical picture of a 30-year-old man after accidental petroleum aspiration. In addition to the usual clinical and instrumental examinations, we also performed, for the first time, electron microscopic investigations of the BAL specimen. A striking finding was the occurrence of macrophages (40%) with numerous lipoid inclusions that exhibited all morphologic signs of an activation as well as neutrophil granulocytes (33%), lymphocytes (21%), and eosinophils (6%). Despite a large and necrotizing infiltration of the right lower lobe, the clinical course was uneventful with complete recovery.