Neuroaugmentation in the treatment of complex regional pain syndrome of the upper extremity.

The authors report their results on 36 patients with advanced stages of complex regional pain syndrome. They were treated with either spinal cord stimulation, or peripheral nerve stimulation, and in some cases with both modalities. Thirty six months after implantation the reported pain measured on visual analogue scales was an average of 53% better, this change was statistically significant. Analgesic consumption decreased by about 50% or was reportedly more effective. The authors conclude that in late stages of complex regional pain syndrome, neuroaugmentation is a reasonable option when alternative therapies have failed.

Neuroaugmentation in the management of sacroiliac joint pain. Report of two cases.

STUDY DESIGN: A report of two cases of severe sacroiliac pain that were resistant to conventional management techniques. Both patients had undergone lumbar fusion. This appeared to be a predisposing factor. OBJECTIVE: To define the source of pain in these patients by performing a series of diagnostic blocks under fluoroscopic guidance to determine if these patients were candidates for neuroaugmentation. SUMMARY OF BACKGROUND DATA: Mild to moderate sacroiliac joint pain can be managed conservatively with analgesics, anti-inflammatory drugs, and physical therapy. Severe sacroiliac joint pain can be incapacitating and more challenging to manage. Fluoroscopically guided intra-articular local anesthetic-steroid injections, followed by joint manipulation, can be effective, intracapsular injections of glycerin, glucose, and phenol also may be beneficial in some patients. The use of neuroaugmentation to manage pain of synovial origin has not been reported previously. Sacral nerve root stimulation in particular has been used to manage urinary bladder dysfunction and pain, but not sacroiliac joint pain. METHODS: Two patients with severe sacroiliac joint pain were treated by implanting a neuroprosthesis at the third sacral nerve roots. The patients had undergone lumbar fusion for back pain that developed as a result of work-related injuries. Stimulation was tried for 1 week with bilateral, percutaneously implanted, cardiac pacing wires at the third sacral nerve roots. RESULTS: Both patients experienced relief of approximately 60% of their pain during the trial period. Therefore, a neuroprosthesis (Medtronics, MN) was implanted permanently bilaterally at the third sacral nerve root in both patients. The use of analgesics was reportedly the same after implantation, but significantly more effective, and the patients' daily living activities were more tolerable. CONCLUSIONS: Two cases of refractory sacroiliac joint pain are reported that were managed with permanently implanted neuroprostheses at the third sacral nerve roots. The authors suggest that neuroaugmentation can be a reasonable option in selected patients with refractory sacroiliac pain.

Anesthesia for ophthalmic surgery in the elderly: the effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthetic requirement.

The effects of clonidine on intraocular pressure and perioperative cardiovascular variables were studied by a randomized double blind design in 80 elderly patients (ASA physical status I-III) scheduled for elective ophthalmic surgery under general anesthesia (GA) and local anesthesia (LA). Group 1 (n = 40), the control group, received diazepam po (0.1 mg.kg-1) 90-120 min prior to arrival to the operating room. Group 2 (n = 40) received clonidine po approximately 5 micrograms.kg-1 po at the same time. Each group was divided into subgroups of 20 patients each to be managed with GA (GA subset) or LA (LA subset). Ninety to 120 minutes after the premedication, a large decrease in IOP from 20 +/- 3 to 12 +/- 3 mmHg (P less than 0.01) and a small but significant reduction of both systolic and diastolic BP and HR were observed in patients receiving clonidine, while no changes occurred in controls. In the patients managed with GA, clonidine effectively prevented IOP rise and attenuated the associated cardiovascular response (P less than 0.01) following laryngoscopy and tracheal intubation, and significantly reduced intraoperative cardiovascular lability and anesthetic requirement for isoflurane (P less than 0.05) and for fentanyl (P less than .001). In patients managed with LA, intraoperative systolic (P less than 0.01) and diastolic BP and HR variability (P less than 0.05) were significantly lower in patients receiving clonidine as compared to controls. Intraoperatively, a significantly higher incidence of hypertension (P less than 0.01) and tachycardia (P less than 0.05) were respectively observed in the LA subset and GA subset of the controls when contrasted with the corresponding subset of those receiving clonidine. Moreover, clonidine was more effective than diazepam as a premedication; in fact, satisfactory intraoperative sedation and cardiovascular stability were observed in 85% of the patients who received clonidine, and in 50% of those patients who did not receive clonidine (P less than 0.01). Thus, clonidine may represent a useful adjunct in the management of the aged patient in the setting of ophthalmic surgery.