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1.
Curr Med Chem ; 29(6): 1061-1082, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-34375181

RESUMEN

Cancer is a pathology that impacts in a profound manner all over the world. The election strategy against cancer often uses chemotherapy and radiotherapy, which, more often than not, can present many side effects and are not always considered reliable efficacy. By contrast, it is widely known that a diet rich in fruit and vegetables has a protective effect against cancer insurgence and development. Polyphenols are generally believed to be responsible for those beneficial actions, at least partially. In this review, we highlight the metabolic interaction between polyphenols and our metabolism and discuss their potential for anticancer prevention and therapy.


Asunto(s)
Neoplasias , Polifenoles , Antioxidantes/uso terapéutico , Dieta , Frutas , Humanos , Neoplasias/tratamiento farmacológico , Neoplasias/prevención & control , Polifenoles/farmacología , Polifenoles/uso terapéutico , Verduras
2.
Artículo en Inglés | MEDLINE | ID: mdl-33167849

RESUMEN

BACKGROUND: Dysbiosis is related to changes in the composition and behaviour of intestinal microbiota, which may contribute to an age-related decline in metabolic and immune system functioning (immune-senescence). OBJECTIVE: The microbiota-targeted dietary and probiotic interventions have been shown to favorably affect the host health by an enhancement of antioxidant activity, improving immune homeostasis, suppression of chronic inflammation, regulation of metabolism and prevention of insulin resistance. RESULTS: In our study, the use of specific probiotics strains improved the serum concentration of glycemic markers, thereby promoting better overall health. CONCLUSION: Probiotics may help correct defects in the gut microbial environment improving metabolic parameters, such as blood sugar levels, glycosylated hemoglobin and a decrease in body weight.


Asunto(s)
Glucemia/efectos de los fármacos , Colecalciferol/uso terapéutico , Microbioma Gastrointestinal , Control Glucémico , Intestinos/microbiología , Lagerstroemia , Extractos Vegetales/uso terapéutico , Probióticos/uso terapéutico , Adulto , Albania , Biomarcadores/sangre , Glucemia/metabolismo , Colecalciferol/efectos adversos , Método Doble Ciego , Disbiosis , Femenino , Hemoglobina Glucada/metabolismo , Humanos , Italia , Lagerstroemia/química , Masculino , Persona de Mediana Edad , Extractos Vegetales/efectos adversos , Hojas de la Planta , Probióticos/efectos adversos , Factores de Tiempo , Resultado del Tratamiento , Pérdida de Peso/efectos de los fármacos
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