RESUMEN
OBJECTIVE: To investigate the effect of Modified Zhuye Shigao Decoction (MZSD) and its components on preventing radiation esophagitis of rats. METHODS: One hundred Wistar rats were randomly divided into 5 groups, including the control group, radiation model group, MZSD group, Zhuye Shigao Decoction (ZSD) group, and added ingredients group, 20 rats in each group. The model of radiation esophagitis of rat was established by once local radiation of 40 Gy (330 Mu/min) with a high energy linear accelerator. The administration of Chinese medicine was continued for 14 days from 7 days before radiation application in the three treatment groups. On the 7th and 14th day, the serum was isolated and the levels of inflammatory cytokines tumor necrosis factor (TNF-α), interleukin 1ß (IL-1ß) and IL-8 were tested. The pathological slices of esophagus were obtained, and the pathological changes were observed. During the whole process, weight and food intake were recorded each day. RESULTS: On the 7th day after radiation, the esophagus of rats in the MZSD group was almost intact, and the pathological injury score was significantly lower than that of the radiation model group, ZSD group and added ingredients group (P<0.01). Compared with the control group, the body weight and food intake of rats in the radiation model group were significantly decreased, and the levels of TNF-α, IL-1ß and IL-8 were significantly increased (P<0.05 or P<0.01), while the MZSD group showed a significant increase in body weight and food intake, and a significant decrease in the levels of TNF-α, IL-1ß and IL-8 compared with the radiation model group, ZSD group and added ingredients group (P <0.05 or P<0.01). CONCLUSION: MZSD prevents the development of radiation esophagitis probably by inhibiting the generation and release of the inflammatory cytokines TNF-α, IL-1ß and IL-8.
Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Esofagitis/tratamiento farmacológico , Esofagitis/prevención & control , Traumatismos por Radiación/tratamiento farmacológico , Traumatismos por Radiación/prevención & control , Animales , Peso Corporal/efectos de los fármacos , Citocinas/metabolismo , Medicamentos Herbarios Chinos/farmacología , Esofagitis/patología , Esófago/efectos de los fármacos , Esófago/patología , Conducta Alimentaria/efectos de los fármacos , Mediadores de Inflamación/metabolismo , Masculino , Infiltración Neutrófila/efectos de los fármacos , Traumatismos por Radiación/patología , Ratas Wistar , Factores de TiempoRESUMEN
OBJECTIVE: To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis. METHODS: The articles were mainly retrieved from the "CHKD (China Hospital Knowledge Database) periodical full text databank", the "China periodical full text databank", the "CHKD doctor's and Master's degree student full text databank", and the "China doctor's degree student thesis databank", and they were selected according to the literature selection standard. The effects of Chinese medicines and Western medicines on radiation esophagitis were compared by meta-analysis. RESULTS: Based on 13 articles, we found that the effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis was superior to Western medicines, with no obvious side effects. Meta-analysis showed that the total odds ratio was 0.426 and the 95% confidence interval was 0.368, 0.493. CONCLUSION: Chinese medicines are superior to Western medicines in preventing and treating radiation esophagitis. However, some methodological problems in the literature may have affected the authenticity of the results. Therefore, more rigorous, multi-central, randomized controlled trials with a large sample size should be designed to obtain a more reliable conclusion.
Asunto(s)
Esofagitis/tratamiento farmacológico , Medicina Tradicional China , Traumatismos por Radiación/tratamiento farmacológico , Esofagitis/prevención & control , Medicina Basada en la Evidencia , Humanos , Sesgo de Publicación , Qi , Traumatismos por Radiación/prevención & controlRESUMEN
OBJECTIVE: To explore the preventive and therapeutic effects of Compound Zhuye Shigao Granule (CZSG), a compound Chinese herbal medicine, on radiation-induced esophagitis in rats. METHODS: Fifty-six Wistar rats were randomly divided into 5 groups: normal control group (8 rats), model group (12 rats), and high-, medium- and low-dose CZSG groups (12 rats in each group). The rats in the normal control and model groups were given normal saline 10 mL/kg body weight and those in the CZSG-treated groups were given solution of CZSG at doses of 1.15, 2.30, or 4.60 g/kg body weight respectively by intragastric administration once a day for 7 days. Then esophagitis was induced by local irradiation of (60)Co ray (490.25 cGy/min, totaled 30 Gy). The administration was continued for another 7 days or 14 days, meanwhile body weight and daily food intake of the rats were recorded. Seven days after the irradiation, 4 rats in each group were sacrificed under anesthesia, then, the esophageal tissue was obtained for histopathological examination and the degrees of esophageal tissue injury and neutrophil infiltration were scored. Fourteen days after the irradiation, all the survival rats were dealt in the same way. RESULTS: (1) Seven days after the irradiation, the esophageal tissue sections in the model group showed typical histopathological changes of radiation-induced esophagitis, whereas in the CZSG groups the histopathological changes were lessened dose-dependently and in the high-dose CZSG group the esophageal tissue remained basically intact. (2) The scores of esophageal tissue injury and cellular infiltration in the high- and medium-dose CZSG groups were both significantly less than in the model group (P<0.05). (3) The body weight of the rats increased in the normal control group, whereas it decreased obviously in the model group. In the medium- and high-dose CZSG groups, it did not decrease significantly. The decrease of body weight in the high-dose CZSG group was less than that in the model group (P<0.05). (4) Compared with the normal control group, the daily food intake was reduced in the other groups. However, it was significantly greater in the low, medium- and high-dose CZSG groups than in the model group (P<0.05). CONCLUSION: In rats with radiation-induced esophagitis, CZSG can effectively relieve the esophageal tissue injury and cellular infiltration, increase daily food intake, and prevent rats from lose of body weight dose-dependently, which show that CZSG has the preventive and therapeutic effects for radiation-induced esophagitis in rats.